2-(4-Allyl-2,6-dimethoxy-phenoxy)-1-benzo[1,3]dioxol-5-yl-propan-1-ol | 50354-29-5

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 2-(4-Allyl-2,6-dimethoxy-phenoxy)-1-benzo[1,3]dioxol-5-yl-propan-1-ol
• 英文别名: 2-(4-Allyl-2,6-dimethoxyphenoxy)-1-(3,4-methylenedioxyphenyl)-1-propanol；1-(1,3-benzodioxol-5-yl)-2-(2,6-dimethoxy-4-prop-2-enylphenoxy)propan-1-ol
• CAS: 50354-29-5
• 化学式: C₂₁H₂₄O₆
• 分子量: 372.418
• InChiKey: RRMZKOOCNBRGQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(4-allyl-2,6-dimethoxy-phenoxy)-1-benzo[1,3]dioxol-5-yl-propan-1-one 在 sodium tetrahydroborate 、 15-冠醚-5 作用下， 以 甲醇 、 异丙醇 为溶剂， 反应 4.0h， 以73%的产率得到2-(4-Allyl-2,6-dimethoxy-phenoxy)-1-benzo[1,3]dioxol-5-yl-propan-1-ol
  参考文献：
  名称：

  In Vitro Evaluation of Antifungal Properties of 8.O.4‘-Neolignans

  摘要：

  Eighteen racemic 8.O.4'-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and three alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (+/-)-erythro-3,4-(methylenedioxy)-7-hydroxy-1'-allyl-3'5'-dimethoxy-8.O.4'-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.

  DOI：

  10.1021/np9605504

文献信息

• In Vitro Evaluation of Antifungal Properties of 8.O.4‘-Neolignans
  作者：Susana Zacchino、Gladis Rodríguez、Germán Pezzenati、Gabriela Orellana、Ricardo Enriz、Manuel Gonzalez Sierra

  DOI：10.1021/np9605504

  日期：1997.7.1

  Eighteen racemic 8.O.4'-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and three alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (+/-)-erythro-3,4-(methylenedioxy)-7-hydroxy-1'-allyl-3'5'-dimethoxy-8.O.4'-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.