(+/-)-3-(2-quinolinyloxy)-1-aza-bicyclo[2.2.2]octane | 121459-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (+/-)-3-(2-quinolinyloxy)-1-aza-bicyclo[2.2.2]octane
• 英文别名: 2-Quinolinyl 3-quinuclidinyl ether；1-Azabicyclo[2.2.2]octane, 3-(2-quinolinyloxy)-；2-(1-azabicyclo[2.2.2]octan-3-yloxy)quinoline
• CAS: 121459-25-4
• 化学式: C₁₆H₁₈N₂O
• 分子量: 254.332
• InChiKey: LRQZHEAZRKGYRO-UHFFFAOYSA-N

物化性质

• 沸点：
  388.4±22.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯喹啉 、 二甲基亚砜 生成 (+/-)-3-(2-quinolinyloxy)-1-aza-bicyclo[2.2.2]octane
  参考文献：
  名称：

  Ethers

  摘要：

  式为##STR1##的新型醚类，它们的杂环芳香族N-氧化物以及式为(I)的化合物及其N-氧化物的药学可接受的酸加成物具有5-HT.sub.3-拮抗活性。在公式中，##STR2##代表一个可选取代的杂芳基团，其中包含一个杂原子X，--B代表一个饱和的氮杂双环环，例如喹诺啡基或曲普啡基。

  公开号：

  US04929625A1

文献信息

• [EN] NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE<br/>[FR] NOUVEAUX DERIVES QUINUCLIDINIQUES ET LEUR UTILISATION
  申请人：NEUROSEARCH AS

  公开号：WO2004016608A1

  公开（公告）日：2004-02-26

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  该发明涉及新型喹诺啉衍生物及其作为药物的用途。由于其药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由于滥用化学物质终止而引起的戒断症状等疾病或疾病有用。
• Novel quinuclidine derivatives and their use
  申请人：Peters Dan

  公开号：US20050245567A1

  公开（公告）日：2005-11-03

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的莨菪碱衍生物及其作为药物的使用。由于它们的药理特性，本发明中的化合物可能对治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统有关的疾病或疾患、与平滑肌收缩有关的疾病或疾患、内分泌疾病或疾患、神经退行性疾病或疾患、与炎症、疼痛有关的疾病或疾患以及因化学物质滥用终止而引起的戒断症状可能有用。
• NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE
  申请人：PETERS Dan

  公开号：US20090005390A1

  公开（公告）日：2009-01-01

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的蒽环啶衍生物及其作为药物的用途。由于它们的药理特性，本发明中的化合物可能对多种与中枢神经系统（CNS）、外周神经系统（PNS）、平滑肌收缩有关的疾病或紊乱，内分泌疾病或紊乱，神经退行性疾病或紊乱，炎症、疼痛以及由于滥用化学物质而导致的戒断症状等疾病或紊乱有用。
• Azabicyclic ethers
  申请人：JOHN WYETH & BROTHER LIMITED

  公开号：EP0306148A2

  公开（公告）日：1989-03-08

  Novel ethers of formula their heteroaromatic N-oxides, and the pharmaceutically acceptable acid additions of the compounds of formula (I) and their N-oxides possess 5-HT₃-antagonistic activity. In the formula represents an optionally substituted heteroaryl group containing a hetero atom X and -B represents a saturated azabicyclic ring such as quinuclidyl or tropanyl.

  新颖的式醚 式(I)化合物及其 N-氧化物的杂芳香族 N-氧化物和药学上可接受的酸加成物具有 5-HT₃拮抗活性。式中 代表含有杂原子 X 的任选取代的杂芳基，-B 代表饱和的氮杂环，如奎尼环或托潘尼环。
• Quinuclidine derivatives and their use
  申请人：NEUROSEARCH A/S

  公开号：EP1905771A2

  公开（公告）日：2008-04-02

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型奎宁环衍生物及其药物用途。由于其药理特性，本发明的化合物可用于治疗各种疾病或失调，如与中枢神经系统（CNS）胆碱能系统、周围神经系统（PNS）、平滑肌收缩相关的疾病或失调、内分泌疾病或失调、神经变性相关的疾病或失调、炎症相关的疾病或失调、疼痛以及终止滥用化学物质引起的戒断症状。