5,7-二氯-8-喹啉基乙酸酯 | 52174-94-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 5,7-二氯-8-喹啉基乙酸酯
• 英文名称: 5,7-dichloroquinolin-8-yl acetate
• 英文别名: acetic acid-(5,7-dichloro-[8]quinolyl ester)；Essigsaeure-(5,7-dichlor-[8]chinolylester)；5,7-dichloro-8-quinolyl acetate；5,7-Dichloro-8-acetoxyquinoline；(5,7-dichloroquinolin-8-yl) acetate
• CAS: 52174-94-4
• 化学式: C₁₁H₇Cl₂NO₂
• 分子量: 256.088
• InChiKey: YLHTUGZWCAVVON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 5,7-二氯-8-喹啉基乙酸酯
  参考文献：
  名称：

  Hebebrand, Chemische Berichte, 1888, vol. 21, p. 2979,2983

  摘要：

  DOI：

文献信息

• Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases
  申请人：Olaleye Omonike Arike

  公开号：US20150141415A1

  公开（公告）日：2015-05-21

  The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivatives thereof or a pharmaceutical salts thereof.
• Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases
  申请人：Olaleye Omonike A.

  公开号：US20170304288A1

  公开（公告）日：2017-10-26

  Provided herein are formulations and co-solvent formulations and methods for treating an infectious disease utilizing the same. The formulations and co-solvent formulations may comprise a hydroxyquinoline analog or its pharmaceutically acceptable salt, a solvent and at least two surfactants. Also provided are methods of quantitating a hydroxyquinoline analog in a sample via chromatographic/spectrometric measurements.
• [EN] METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ POUR TRAITER DES INFECTIONS BACTÉRIENNES RÉSISTANT AU MÉDICAMENT ET D'AUTRES INFECTIONS PAR DU CLIOQUINOL, DE LA PHANQUINONE ET DES COMPOSÉS APPARENTÉS
  申请人：XILINAS MICHEL E

  公开号：WO2009140215A2

  公开（公告）日：2009-11-19

  The invention relates to new uses of known chelating compounds for the treatment of bacterial in fungal infections, particularly by methicilllin-resistant and other drug-resistant strains of bacteria and fungi. One of more chelating compound is administered with or without additional antibiotic or antifungal drugs to achieve improved therapy. Preferred chelating compounds include clioquinol, 5,7-dichloro-8-hydroxy-quinaldine, phanquinone, 5,7-dichloro-8-hydroxyquinoline, 5,7- di-iodo-8-hydroxyquinoline. By chelation of specific metal ions, these compounds treat any infection by bacteria or fungi whose pathogenicity depends upon metalloenzymes that require these cations. The compounds are also effective against infections caused by extended β lactamase and metallo β lactamase producing bacterial strains. Bacteria targeted by these methods include methicillin-resistant Staphylococcus aureus, penicillin resistant or intermediate resistant Streptococcus pneumoniae and other gram positive and multiresistant gram negative species and strains.
• [EN] METHIONINE AMINOPEPTIDASE INHIBITORS FOR TREATING INFECTIOUS DISEASES<br/>[FR] INHIBITEURS DE LA MÉTHIONINE AMINOPEPTIDASE POUR LE TRAITEMENT DE MALADIES INFECTIEUSES
  申请人：TEXAS SOUTHERN UNIVERSITY

  公开号：WO2015077057A1

  公开（公告）日：2015-05-28

  The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivatives thereof or a pharmaceutical salts thereof.