[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1E)-N-sulfooxybut-3-enimidothioate | 534-69-0

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1E)-N-sulfooxybut-3-enimidothioate
• CAS: 534-69-0
• 化学式: C₁₀H₁₇NO₉S₂
• 分子量: 359.4
• InChiKey: PHZOWSSBXJXFOR-PTGZALFTSA-N

物化性质

• 密度：
  1.76±0.1 g/cm3(Predicted)
• LogP：
  1.049 (est)
• 物理描述：
  Solid
• 熔点：
  125-127°C

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  200
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• 3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same
  申请人：The Fanning Corporation

  公开号：US20020147365A1

  公开（公告）日：2002-10-10

  1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.

  提供了一种抗氧化化合物，其为1-(3-甲氧基苄基)-3-取代硫脲，以及通过添加这些抗氧化化合物的有效量来改善脂质组成，从而增强基础脂质的氧化稳定性的方法。还提供了一种增强脂质氧化稳定性的方法，该方法包括向需要增强氧化稳定性的基础脂质中补充至少一种本发明所述的1-(3-甲氧基苄基)-3-取代硫脲化合物。
• [EN] INHIBITING HYDROCARBON HYDRATE AGGLOMERATION<br/>[FR] INHIBITION DE L'AGGLOMÉRATION D'HYDRATES D'HYDROCARBURES
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2018218281A1

  公开（公告）日：2018-12-06

  A process for inhibiting the formation of gas hydrates in a hydrocarbon fluid comprising adding to the hydrocarbon fluid, a gas hydrate anti-agglomerate which is a biodegradable anti-agglomerant derived from a naturally occurring substance.

  一种抑制碳氢化合物流体中天然气水合物形成的方法包括向碳氢化合物流体中添加一种气体水合物抗凝聚剂，该抗凝聚剂是一种可生物降解的抗凝聚剂，来源于天然存在的物质。
• 3-Methoxybenzyl thiourea derivatives and improved lipid compositions containing same
  申请人：the United States of America, as Represented by the Secretary of Agriculture

  公开号：US20030204113A1

  公开（公告）日：2003-10-30

  1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.

  本发明提供了1-(3-甲氧基苯基)-3-取代硫脲抗氧化化合物和改善的脂质组成物，其含有有效增强基础脂质氧化稳定性的抗氧化化合物的量。同时还提供了增强脂质氧化稳定性的方法，包括将需要增强氧化稳定性的基础脂质补充至少一种本发明的1-(3-甲氧基苯基)-3-取代硫脲化合物。
• Herbal compositions useful as chemopreventive and therapeutic agents and methods of manufacturing same
  申请人：Global Cancer Strategies Ltd.

  公开号：US20030099725A1

  公开（公告）日：2003-05-29

  Compositions derived from traditional Chinese herbal medicines, medicinal plants and extracts thereof, are provided for the prevention and treatment of cancers especially cancer of the lung, esophagus, stomach, oral cavity and prostate as well as for treating Helicobacter pylori infection. The compositions of the invention are obtained through specific techniques and have demonstrated efficacy for chemoprevention of cancers of the lung, esophagus, stomach, and the oral cavity as well as exhibiting in vitro activity against prostate cancer and leukemic cell lines. The compositions are useful as adjuncts to conventional surgery or radiotherapy treatments in patients with esophageal cancer. The compositions are effective as a treatment for H. pylori infection. Currently, there is no effective chemopreventive agent for these cancers. The current invention addresses a special need in cancer control. Preferred compositions of the invention contain the herbal ingredients Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus brachyotus, Dictamnus dasycarpus Turcz, and Dioscorea bulbifera.

  本发明提供了从传统中草药、药用植物及其提取物中提取的组合物，用于预防和治疗癌症，特别是肺癌、食管癌、胃癌、口腔癌和前列腺癌，以及治疗幽门螺杆菌感染。本发明的组合物通过特定技术获得，并已证明对肺癌、食管癌、胃癌、口腔癌具有化学预防功效，并在体外表现出对前列腺癌和白血病细胞系的活性。该组合物可作为食管癌患者常规手术或放疗治疗的辅助治疗。该组合物对H. pylori感染有效。目前没有有效的化学预防剂可用于这些癌症。本发明解决了癌症控制中的特殊需求。本发明的优选组合物包含草药Sophora tonkinensis、Polygonum bistorta、Prunella vulgaris、Sonchus brachyotus、Dictamnus dasycarpus Turcz和Dioscorea bulbifera的成分。
• Process for the manufacture of a herbal composition
  申请人：——

  公开号：US20040170704A1

  公开（公告）日：2004-09-02

  The present invention is concerned with a process for the manufacture of a herbal composition, said process comprising: a. subjecting a matrine containing plant material, in the absence of a plant material derived from the species Dictamnus, to an extraction with an aqueous solvent, optionally followed by a concentration step, to produce a herbal extract I; b. subjecting a plant material derived from the species Dictamnus, to an extraction with an aqueous solvent, optionally followed by a concentration step, to produce a herbal extract II; c. mixing the herbal extracts I and II; d. provided the resulting mixture contains a significant amount of water, drying the mixture to a water content of less than 6 wt. %. The herbal composition according to the present invention may advantageously be used in a method of treating or preventing cancer, H. pylori infections, chronic inflammatory conditions, cardiovascular diseases or cerebral vascular diseases in mammals.

  本发明涉及一种制造草药组合物的过程，该过程包括：a. 在不含来自紫茉莉属物种的植物材料的情况下，将含有苦参碱的植物材料用水溶剂进行提取，可选地进行浓缩步骤，以产生草药提取物I; b. 将来自紫茉莉属物种的植物材料用水溶剂进行提取，可选地进行浓缩步骤，以产生草药提取物II; c. 混合草药提取物I和II; d. 如果所得混合物含有大量水，将混合物干燥至水含量小于6重量％。本发明的草药组合物可以优势地用于治疗或预防哺乳动物的癌症、H. pylori感染、慢性炎症疾病、心血管疾病或脑血管疾病的方法中。