(2S,5R,6R)-5-methyl-6-(3-morpholinophenyl)piperidine-2-carboxylic acid | 916914-58-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (2S,5R,6R)-5-methyl-6-(3-morpholinophenyl)piperidine-2-carboxylic acid
• 英文别名: (2S,5R,6R)-5-methyl-6-(3-morpholin-4-ylphenyl)piperidine-2-carboxylic acid
• CAS: 916914-58-4
• 化学式: C₁₇H₂₄N₂O₃
• 分子量: 304.389
• InChiKey: DHTWOSUFEXXKBS-UHOFOFEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  61.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S,5R,6R)-6-(3-bromophenyl)-5-methylpiperidine-2-carboxylic acid 、 (2S,5R,6R)-5-methyl-6-(3-morpholinophenyl)piperidine-2-carboxylic acid 在 2,3,5-三甲基吡啶 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 以28%的产率得到(3R,4R,7R,8R,9aS,10aS)-4-(3-Bromo-phenyl)-3,7-dimethyl-8-(3-morpholin-4-yl-phenyl)-octahydro-4a,8a-diaza-anthraquinone
  参考文献：
  名称：

  Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets

  摘要：

  A convergent approach to highly functionalized diketopiperazines (DKPs) using enantioenriched pipecolic acids is described. Scandium triflate-catalyzed [4 + 2] aza-annulation was employed to produce stereochemically well-defined building blocks. A resin "catch and release" strategy was devised to convert annulation products to pipecolic acid monomers. Complex diketopiperazines were efficiently assembled utilizing one-pot cyclodimerization of pipecolic acids. Massively parallel screening of the complex DKPs against a panel of molecular targets identified novel ligands for a number of G-protein-coupled receptors (GPCRs).

  DOI：

  10.1021/jo061758p
• 作为产物：
  描述：

  (E)-(2R,3R)-2-Amino-3-(dimethyl-phenyl-silanyl)-hex-4-enoic acid methyl ester 在 platinum(IV) oxide 、 tris(dibenzylideneacetone)dipalladium (0) sodium tetrahydroborate 、 potassium phosphate 、 Amberlyst A₂₆ hydroxide resin 、 氢气 、 magnesium sulfate 、 三氟乙酸 、 三氟乙酸酐 、 2-(二环己基膦基)联苯 、 scandium tris(trifluoromethanesulfonate) 作用下， 以 四氢呋喃 、 甲醇 、 乙二醇二甲醚 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 反应 15.0h， 生成 (2S,5R,6R)-5-methyl-6-(3-morpholinophenyl)piperidine-2-carboxylic acid
  参考文献：
  名称：

  Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets

  摘要：

  A convergent approach to highly functionalized diketopiperazines (DKPs) using enantioenriched pipecolic acids is described. Scandium triflate-catalyzed [4 + 2] aza-annulation was employed to produce stereochemically well-defined building blocks. A resin "catch and release" strategy was devised to convert annulation products to pipecolic acid monomers. Complex diketopiperazines were efficiently assembled utilizing one-pot cyclodimerization of pipecolic acids. Massively parallel screening of the complex DKPs against a panel of molecular targets identified novel ligands for a number of G-protein-coupled receptors (GPCRs).

  DOI：

  10.1021/jo061758p

文献信息

• Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets
  作者：Sivaraman Dandapani、Ping Lan、Aaron B. Beeler、Scott Beischel、Athier Abbas、Bryan L. Roth、John A. Porco,、James S. Panek

  DOI：10.1021/jo061758p

  日期：2006.11.1

  A convergent approach to highly functionalized diketopiperazines (DKPs) using enantioenriched pipecolic acids is described. Scandium triflate-catalyzed [4 + 2] aza-annulation was employed to produce stereochemically well-defined building blocks. A resin "catch and release" strategy was devised to convert annulation products to pipecolic acid monomers. Complex diketopiperazines were efficiently assembled utilizing one-pot cyclodimerization of pipecolic acids. Massively parallel screening of the complex DKPs against a panel of molecular targets identified novel ligands for a number of G-protein-coupled receptors (GPCRs).