N,N-dibenzyl-1-(4-nitrophenyl)-3-phenylprop-2-yn-1-amine | 1523604-03-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: N,N-dibenzyl-1-(4-nitrophenyl)-3-phenylprop-2-yn-1-amine
• CAS: 1523604-03-6
• 化学式: C₂₉H₂₄N₂O₂
• 分子量: 432.522
• InChiKey: UOMSIRBFGPHRGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(二甲氧基甲基)-4-硝基苯 、 苯乙炔 、 二苄胺 在 indium(III) chloride 作用下， 以 甲苯 为溶剂， 以20%的产率得到N,N-dibenzyl-1-(4-nitrophenyl)-3-phenylprop-2-yn-1-amine
  参考文献：
  名称：

  Indium-Catalysed Multicomponent Reaction of Acetals with Dibenzylamine and Alkynes

  摘要：

  A reaction of acetals with dibenzylamine and alkynes to form propargylamines has been developed via the activation of both C(sp3)-O and C(sp)-H bonds by InCl3. The iminium ion has been found to be the key intermediate.

  DOI：

  10.3184/174751913x13816565482472

文献信息

• Solvent effects in gold-catalysed A3-coupling reactions
  作者：Gregory A. Price、Alan K. Brisdon、Kevin R. Flower、Robin G. Pritchard、Peter Quayle

  DOI：10.1016/j.tetlet.2013.10.141

  日期：2014.1

  Gold-catalysed A(3)-reactions proceed efficiently when conducted in 2,2,2-trifluoroethanol as solvent. The rates of these reactions are accelerated considerably when conducted in a microwave reactor. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
• Indium-Catalysed Multicomponent Reaction of Acetals with Dibenzylamine and Alkynes
  作者：Xue-Lin Zhang、Qin-Pei Wu、Qing-Shan Zhang

  DOI：10.3184/174751913x13816565482472

  日期：2013.11

  A reaction of acetals with dibenzylamine and alkynes to form propargylamines has been developed via the activation of both C(sp3)-O and C(sp)-H bonds by InCl3. The iminium ion has been found to be the key intermediate.