[3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (E)-octadec-9-enoate | 62700-69-0

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: [3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (E)-octadec-9-enoate
• CAS: 62700-69-0
• 化学式: C₄₂H₇₉O₁₀P
• 分子量: 775.0
• InChiKey: DSNRWDQKZIEDDB-NADBREJJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  53
• 可旋转键数：
  42
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• DISEASE-SITE-SPECIFIC LIPOSOMAL FORMULATION
  申请人：Osaka University

  公开号：EP3718537A1

  公开（公告）日：2020-10-07

  The present invention provides a clinically applicable, safe and convenient, pharmaceutical composition for disease site-specific treatment. The pharmaceutical composition for disease site-specific treatment comprises a stealth liposome having a prostaglandin I2 receptor agonist encapsulated therein.

  本发明提供了一种临床适用、安全方便、用于疾病部位特异性治疗的药物组合物。这种用于疾病部位特异性治疗的药物组合物包括一种隐形脂质体，其中封装有前列腺素 I2 受体激动剂。
• Controlling translocation through nanopores with fluid walls
  申请人：The Regents of the University of Michigan

  公开号：US10254271B2

  公开（公告）日：2019-04-09

  Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.

  如果在根据库尔特原理运行的设备中，连接液体隔间的纳米孔具有流体涂层（如脂质壁），则可提高纳米粒子的分辨率和检测能力。流体脂质壁由脂质双分子层构成，最好包括脂质锚定移动配体作为脂质双分子层的一部分。通过改变脂质双分子层中可移动配体的性质和浓度，可提供多功能的脂质涂层。
• Nanopore-based determination of protein charge, shape, volume, rotational diffusion coefficient, and dipole moment
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US10317361B2

  公开（公告）日：2019-06-11

  Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.

  当溶液中的大分子在被合成纳米孔分隔和流体耦合的两个液室之间移动时，通过测量移位事件随时间变化的电流 I 来确定大分子的物理参数。电荷、体积、形状、旋转扩散系数和偶极矩的值都是通过测量得出的。
• Nanopore-based determination of protein charge, sharp, volume, rotational diffusion coefficient, and dipole moment
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US10656117B2

  公开（公告）日：2020-05-19

  Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.

  当溶液中的大分子在被合成纳米孔分隔和流体耦合的两个液室之间移动时，通过测量移位事件随时间变化的电流 I 来确定大分子的物理参数。电荷、体积、形状、旋转扩散系数和偶极矩的值都是通过测量得出的。
• CONTROLLING TRANSLOCATION THROUGH NANOPORES WITH FLUID WALL
  申请人：Mayer Michael

  公开号：US20130048499A1

  公开（公告）日：2013-02-28

  Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid lipid walls. The fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.