3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one | 904215-76-5

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 呋喃类木脂素
• 英文名称: 3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
• 英文别名: 2-hydroxy-2,3-bis(4-hydroxy-3-methoxybenzyl)-4-butanolide；3-hydroxy-3,4-bis(4-hydroxy-3-methoxybenzyl)-dihydrofuran-2(3H)-one；Trachelogeninsaeure；wikstromol；3-hydroxy-3,4-bis-(4-hydroxy-3-methoxy-benzyl)-dihydro-furan-2-one；nortachelogenin
• CAS: 904215-76-5
• 化学式: C₂₀H₂₂O₇
• 分子量: 374.39
• InChiKey: ZITBJWXLODLDRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Cosmetic compositions decreasing GM-CSF release induced by nickel salts
  申请人：Cognis IP Management GmbH

  公开号：EP1902755A1

  公开（公告）日：2008-03-26

  Suggested are cosmetic compositions comprising: (a) a working amount of at least one agent that decreases the GMCSF release induced by nickel salt and (b) a cosmetically acceptable excipient.

  建议的化妆品组合物包括 (a) 至少一种能减少镍盐诱导的 GMCSF 释放的制剂的工作量，以及 (b) 化妆品可接受的赋形剂。
• Composition and method for treating skin by administering silybin and piperine/terahydropiperine
  申请人：Cognis IP Management GmbH

  公开号：EP1902756A1

  公开（公告）日：2008-03-26

  Suggested are cosmetic compositions comprising in a cosmetically acceptable excipient (a) silybin and (b) piperine and/or tetrahydropiperine. The compositions are suitable for preventing and/or soothing dry skin or reactive skin against external stresses.

  建议的化妆品组合物含有化妆品可接受赋形剂 (a) 水飞蓟宾和 (b) 胡椒碱和/或四氢哌啶。这些复合物适用于预防和/或舒缓皮肤干燥或皮肤对外界压力的反应。
• Bestimmte Vanillyllignane und deren Verwendung als Geschmacksverbesserer
  申请人：Symrise AG

  公开号：EP2517574A1

  公开（公告）日：2012-10-31

  Die Erfindung betrifft die Verwendung bestimmter Verbindungen aus der Strukturklasse der Vanillyllignane bzw. deren Salze und/oder Gemische zur Veränderung bzw. Maskierung unangenehmer Geschmackseindrücke, insbesondere bitterer, adstringierender und/oder metallischer Geschmackseindrücke. Die Erfindung betrifft auch ein entsprechendes Verfahren zur Maskierung unangenehmer Geschmackseindrücke, insbesondere bitterer, adstringierender und/oder metallischer Geschmackseindrücke. Ferner betrifft die Erfindung bestimmte Zubereitungen, die einen wirksamen Gehalt an erfindungsgemäß einzusetzenden Vanillyllignanen bzw. deren Salzen und/oder Gemischen enthalten.

  本发明涉及香草木脂素结构类别中某些化合物或其盐类和/或混合物用于改变或掩盖不愉快的味觉，特别是苦味、涩味和/或金属味觉。本发明还涉及一种用于掩盖不愉快味觉，特别是苦味、涩味和/或金属味觉的相应方法。此外，本发明还涉及某些制剂，这些制剂含有有效含量的香草木脂素或其盐类和/或混合物，可根据本发明使用。
• Cosmetic Compositions
  申请人：Danoux Louis

  公开号：US20090298783A1

  公开（公告）日：2009-12-03

  Disclosed is a method for preventing and/or soothing dry or sensitive skin against external stresses, comprising contacting the skin with a composition including an agent that decreases the release of granulocyte-macrophage colony-stimulating factor (GMCSF) from keratinocytes in the skin, wherein under conditions of external stress, dry or sensitive skin is soothed and/or prevented. Agents that decrease the release of GMCSF include silybin, piperine, tetrahydropiperine, nortrachelogenine, rhapontin, arctiin, artigenin and mixtures thereof. Also disclosed is a method of identifying an agent that decreases the level of GMCSF released from keratinocytes.
• Specific Vanillyl Lignans And Use Thereof As Taste Improvers
  申请人：Backes Michael

  公开号：US20140050835A1

  公开（公告）日：2014-02-20

  The invention relates to the use of specific compounds from the structural class of vanillyl lignans or the salts and/or mixtures thereof for modifying or masking unpleasant taste impressions, in particular bitter, astringent, and/or metallic taste impressions. The invention also relates to a corresponding method for masking unpleasant taste impressions, in particular bitter, astringent, and/or metallic taste impressions. The invention further relates to specific preparations containing an effective amount of vanillyl lignans or the salts and/or mixtures thereof to be used in accordance with the invention.