2,2,5-trimethyl-4-phenyl-1,3-dioxolane | 164577-21-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,5-trimethyl-4-phenyl-1,3-dioxolane
• 英文别名: 2,2,4-Trimethyl-5-phenyl-1,3-dioxolane
• CAS: 164577-21-3
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: XHBYNHZRKPAKRJ-UHFFFAOYSA-N

物化性质

• 沸点：
  256.7±25.0 °C(Predicted)
• 密度：
  0.994±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,5-trimethyl-4-phenyl-1,3-dioxolane 在 二甲基二环氧乙烷 作用下， 以 丙酮 为溶剂， 以85%的产率得到2-羟基苯丙酮
  参考文献：
  名称：

  Efficient desymmetrization of 1,2 and 1,3 diols by dimethyldioxirane

  摘要：

  Dimethyldioxirane was used to monooxidize 1,2 and 1,3 sec,sec-diols to the corresponding ketoalcohols, exploiting the inhibiting effect of the formed carbonyl group on the course of the process.

  DOI：

  10.1016/0040-4039(95)00419-d
• 作为产物：
  描述：

  1-苯基丙烷-1,2-二醇 、 丙酮 在 对甲苯磺酸 、 copper(II) sulfate 作用下， 生成 2,2,5-trimethyl-4-phenyl-1,3-dioxolane
  参考文献：
  名称：

  Chromyl complexes in the direct epoxidation of alkenes

  摘要：

  DOI：

  10.1021/ja00346a044

文献信息

• Fine regioselective tuning in the oxidation of sec,sec 1,2-diols by dimethyldioxirane
  作者：Paolo Bovicelli、Anna Sanetti、Paolo Lupattelli

  DOI：10.1016/0040-4020(96)00615-1

  日期：1996.8

  Non symmetric sec,sec 1.2-diols and their O-isopropylidene derivatives undergo a regioselective oxidation by dimethyldioxirane depending on the electronic effects of the substituents. These results support previous views about the concerted -insertion mechanism via a polar transition state.

  根据取代基的电子效应，不对称的仲，仲1.2-二醇及其O-异亚丙基衍生物会受到二甲基二环氧乙烷的区域选择性氧化。这些结果支持以前关于通过极性过渡状态的协调插入机制的观点。
• A Mild Stereo- and Enantiospecific Conversion of 2,3-Diaryl-Substituted Oxiranes into 2,2-Dimethyl-1,3-Dioxolanes by an Acetone/Amberlyst 15 System
  作者：Arlette Solladié-Cavallo、Elias Choucair、Milan Balaz、Paolo Lupattelli、Carlo Bonini、Nadia Di Blasio

  DOI：10.1002/ejoc.200600034

  日期：2006.7

  Amberlyst 15 is an efficient catalyst for the reaction of aryl-substituted oxiranes with acetone to prepare 2,2-dimethyl-1,3-dioxolanes in high yields. trans-2,3-Diaryloxiranes afford trans-acetonides enantiospecifically at room temperature, and the use of enantiopure 2,3-diaryloxiranes results in no loss of stereochemical integrity in the resulting trans-acetonides. (© Wiley-VCH Verlag GmbH & Co.

  Amberlyst 15 是芳基取代的环氧乙烷与丙酮反应以高产率制备 2,2-二甲基-1,3-二氧戊环的有效催化剂。反式-2,3-二芳基环氧乙烷在室温下对映特异性地提供反式丙酮化物，使用对映纯的2,3-二芳基环氧乙烷不会导致所得反式丙酮化物的立体化学完整性损失。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
• FUGANTI C.; GRASSELLI P., CHEM. AND IND., 1977, NO 24, 983
  作者：FUGANTI C.、 GRASSELLI P.

  DOI：——

  日期：——
• SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：EP3079685A1

  公开（公告）日：2016-10-19
• [EN] SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN<br/>[FR] COMPOSÉS DE DÉRIVÉ DE SULFAMATE À UTILISER DANS LE TRAITEMENT OU L'ATTÉNUATION DE LA DOULEUR
  申请人：BIO PHARM SOLUTIONS CO LTD

  公开号：WO2015088273A1

  公开（公告）日：2015-06-18

  The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for treating or alleviating pain containing a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or alleviation of pain comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or alleviation of pain; and a use of the sulfamate derivative compound or the pharmaceutically acceptable salt thereof in treating and/or alleviating pain, are provided.