羟基甲基环十二烷 | 1892-12-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 羟基甲基环十二烷
• 中文别名: 环十二烷甲醇
• 英文名称: cyclododecylmethanol
• 英文别名: cyclododecanemethanol；Hydroxymethylcyclododecan；hydroxymethylcyclododecane
• CAS: 1892-12-2
• 化学式: C₁₃H₂₆O
• mdl: MFCD00003719
• 分子量: 198.349
• InChiKey: JQYWAZNRRQRPNN-UHFFFAOYSA-N

物化性质

• 熔点：
  32-33 °C
• 沸点：
  90-94 °C(Press: 0.1 Torr)
• 密度：
  0.856±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2906199090

反应信息

• 作为反应物：
  描述：

  羟基甲基环十二烷 在 aluminum tri-tert-butoxide 、 对苯醌 作用下， 以 苯 为溶剂， 生成 环十二烷甲醛
  参考文献：
  名称：

  Casanova,J.; Waegell,B., Bulletin de la Societe Chimique de France, 1971, p. 1295 - 1298

  摘要：

  DOI：
• 作为产物：
  描述：

  1-亚甲基环十二烷 生成 羟基甲基环十二烷
  参考文献：
  名称：

  Casanova,J.; Waegell,B., Bulletin de la Societe Chimique de France, 1971, p. 1295 - 1298

  摘要：

  DOI：

文献信息

• Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A.sub
  申请人：American Home Products Corporation

  公开号：US05366993A1

  公开（公告）日：1994-11-22

  There are disclosed compounds of the formula: ##STR1## wherein X is O, S or NR; R is hydrogen or lower alkyl; R.sup.1 and R.sup.2 are each, independently, hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p.ltoreq.15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA.sub.2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.

  披露了具有以下公式的化合物：##STR1## 其中X是O，S或NR；R是氢或低级烷基；R.sup.1和R.sup.2各自独立地为氢，C.sub.1-C.sub.10烷基，C.sub.3-C.sub.20环烷基，苯基低级烷基，或被卤素，低级烷基，低级烷氧基，卤素低级烷基，氨基，单低级烷基氨基，二低级烷基氨基或磺酰氨基取代的取代苯基低级烷基；A是O，S，NR或化学键；m是0-15；n是0-20；p是0-15，其中m+p≤15；以及药理上可接受的盐，由于其能够抑制PLA.sub.2，因此可用作抗炎剂，并且还披露了用于治疗免疫炎性疾病的方法，例如过敏，过敏性反应，哮喘和哺乳动物的炎症，以及调节PAF介导的生物学过程，如胚胎植入，从而使化合物作为抗生育剂是有用的。
• Tandem Catalysis: Transforming Alcohols to Alkenes by Oxidative Dehydroxymethylation
  作者：Xuesong Wu、Faben A. Cruz、Alexander Lu、Vy M. Dong

  DOI：10.1021/jacs.8b06069

  日期：2018.8.15

  a Rh-catalyst for accessing olefins from primary alcohols by a C-C bond cleavage that results in dehomologation. This functional group interconversion proceeds by an oxidation-dehydroformylation enabled by N, N-dimethylacrylamide as a sacrificial acceptor of hydrogen gas. Alcohols with diverse functionality and structure undergo oxidative dehydroxymethylation to access the corresponding olefins. Our

  我们报道了一种 Rh 催化剂，用于通过 CC 键断裂从伯醇中获取烯烃，从而导致脱同系反应。这种官能团互变通过 N,N-二甲基丙烯酰胺作为氢气的牺牲受体实现的氧化-脱氢甲酰化进行。具有不同官能度和结构的醇经过氧化脱羟甲基反应得到相应的烯烃。我们的催化剂方案能够实现 (+)-育亨苯酮的两步半合成和原料烯烃的脱同系。
• [EN] PROPOFOL PHOSPHONYL DERIVATIVES, SYNTHESIS, AND USE IN LONG ACTING FORMULATIONS<br/>[FR] DÉRIVÉS DE PROPOFOL PHOSPHONYLE, SYNTHÈSE, ET UTILISATION DANS DES PRÉPARATIONS À LONGUE DURÉE D'ACTION
  申请人：SEPS PHARMA N V

  公开号：WO2010115869A1

  公开（公告）日：2010-10-14

  This invention relates to compounds represented by the structural formula (I), and the salts and stereoisomers thereof, wherein: - L is a linker selected from the group consisting of -(CH2)P-O-, a single bond, formula (IA), -(CH2)1-8-O-X(O)-, and - p is an integer from 1 to 8, - each R3 and each R4 is independently selected from the group consisting of C1-20alkyl, C3-12alkyl, C3-12cycloalkyl-C1-4alkyl, saturated heterocyclyl and saturated heterocyclyl-C1-4alkyl, and - X and Y are each independently C or S(O), - Z is selected from the group consisting of O, S(O) and NR5, - W is selected from the group consisting of halogen, OH, S(O)H and O-M+ wherein M+ is a monovalent cation; and - R5 is selected from the group consisting of hydrogen and C1-10 alkyl. These compounds are useful pharmaceutical agents with improved oral bioavailability.

  这项发明涉及由结构式（I）表示的化合物，以及其盐和立体异构体，其中：- L是从羟基-(CH2)P-O-、单键、式（IA）、-( )1-8-O-X(O)-和中选择的连接剂，- p是1到8之间的整数，- 每个R3和每个R4分别从C1-20烷基、C3-12烷基、C3-12环烷基-C1-4烷基、饱和杂环烷基和饱和杂环烷基-C1-4烷基组中选择，- X和Y各自独立地为C或S(O)，- Z从O、S(O)和NR5组中选择，- W从卤素、羟基、S(O)H和O-M+中选择，其中M+是一价阳离子；- R5从氢和C1-10烷基组中选择。这些化合物是具有改善口服生物利用度的有用药物。
• Oxidative Dehydroxymethylation of Alcohols to Produce Olefins
  申请人：The Regents of the University of California

  公开号：US20190262819A1

  公开（公告）日：2019-08-29

  Catalyst compositions for the conversion of aldehyde compounds and primary alcohol compounds to olefins are disclosed herein. Reactions include oxidative dehydroxymethylation processes and oxidative dehydroformylation methods, which are beneficially conducted in the presence of a sacrificial acceptor of H 2 gas, such as N,N-dimethylacrylamide.

  本文揭示了用于将醛类化合物和一次醇类化合物转化为烯烃的催化剂组合物。反应包括氧化脱羟甲基化过程和氧化脱甲基醛化方法，在存在H2气体的牺牲性受体（如N,N-二甲基丙烯酰胺）的情况下有益地进行。
• 2-ALKOXYMETHYL-3-ISOALKENYL-1-METHYLCYCLOPENTENES, USE THEREOF, IN PARTICULAR AS FRAGRANCE SUBSTANCES, CORRESPONDING ARTICLES AND PRODUCTION METHODS
  申请人：Panten Johannes

  公开号：US20090092725A1

  公开（公告）日：2009-04-09

  Compounds of formula (A) are described wherein, independently of one another, the following applies to groups R and R 1 : R is methyl or ethyl, and R 1 is hydrogen or methyl, wherein the meandering line shows that for R 1 =methyl, the associated double bind is (E)- or (Z)-configured. Furthermore, methods for producing compounds of formula (A) and the use of corresponding compounds as fragrance and/or flavouring substances are described.

  描述了公式(A)的化合物，其中独立地，对于基团R和R1，以下情况适用：R为甲基或乙基，R1为氢或甲基，其中蜿蜒线表示对于R1=甲基，相关的双键为(E)-或(Z)-构型。此外，还描述了制备公式(A)化合物的方法以及相应化合物作为香料和/或调味物质的用途。