(1H-benzo[d][1,2,3]triazol-1-yl)(3,3-diphenyl-3H-benzo[f]chromen-8-yl)methanone | 1131147-67-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (1H-benzo[d][1,2,3]triazol-1-yl)(3,3-diphenyl-3H-benzo[f]chromen-8-yl)methanone
• 英文别名: Benzotriazol-1-yl-(3,3-diphenylbenzo[f]chromen-8-yl)methanone
• CAS: 1131147-67-5
• 化学式: C₃₂H₂₁N₃O₂
• 分子量: 479.538
• InChiKey: BBVUWVWMAVPMGO-UHFFFAOYSA-N

物化性质

• 熔点：
  206-207 °C (decomp)(Solvent: Dichloromethane; Hexane)
• 沸点：
  702.8±70.0 °C(predicted)
• 密度：
  1.27±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  57
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1H-benzo[d][1,2,3]triazol-1-yl)(3,3-diphenyl-3H-benzo[f]chromen-8-yl)methanone 、 4-氨基丁酸 在 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 6.0h， 以81%的产率得到4-(3,3-diphenyl-3H-benzo[f]chromene-8-carboxamido)butanoic acid
  参考文献：
  名称：

  Gelation Behavior of 2H-Chromene N-Acylamino Acid Conjugates

  摘要：

  [GRAPHICS]2H-Chromene-based conjugates of N-acyl-1,omega-amino acids (5, 9a-f, 14a-f) of natural amino acids (10a,b) and of dipeptide (10c) are prepared (60-97%) by N-acylbenzotriazole methodology in aqueous media at 20 degrees C. Gelation properties of the corresponding sodium salts in DMF and DMSO are generalized with respect to an increase or decrease in the chain length of the spacer.

  DOI：

  10.1021/jo900066m
• 作为产物：
  描述：

  T406石油添加剂 、 3,3-diphenyl-[3H]naphtho [2,1-b]pyran-8-carboxylic acid 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以89%的产率得到(1H-benzo[d][1,2,3]triazol-1-yl)(3,3-diphenyl-3H-benzo[f]chromen-8-yl)methanone
  参考文献：
  名称：

  Gelation Behavior of 2H-Chromene N-Acylamino Acid Conjugates

  摘要：

  [GRAPHICS]2H-Chromene-based conjugates of N-acyl-1,omega-amino acids (5, 9a-f, 14a-f) of natural amino acids (10a,b) and of dipeptide (10c) are prepared (60-97%) by N-acylbenzotriazole methodology in aqueous media at 20 degrees C. Gelation properties of the corresponding sodium salts in DMF and DMSO are generalized with respect to an increase or decrease in the chain length of the spacer.

  DOI：

  10.1021/jo900066m

文献信息

• Oncostatin M (OSM) antagonists for preventing cancer metastasis and IL-6 related disorders
  申请人：Jorcyk Cheryl

  公开号：US10286070B2

  公开（公告）日：2019-05-14

  A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, proliferation and metastasis in several cancer types.

  提供了一种治疗癌症或转移瘤的方法，该方法涉及对受试者施用至少一种Oncostatin M（OSM）拮抗剂，其中受试者已被诊断患有癌症。提供了一种 OSM 拮抗剂（如小分子药物）以及一种抗 OSM 抗体、一种抗 OSM 合酶和一种 OSM mRNA 拮抗剂。研究发现，OSM拮抗剂可抑制或防止几种癌症类型的肿瘤细胞脱落、增殖和转移。
• ONCOSTATIN M (OSM) ANTAGONISTS FOR PREVENTING CANCER METASTASIS AND IL-6 RELATED DISORDERS
  申请人：Jorcyk Cheryl

  公开号：US20150093391A1

  公开（公告）日：2015-04-02

  A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, proliferation and metastasis in several cancer types.
• US9550828B2
  申请人：——

  公开号：US9550828B2

  公开（公告）日：2017-01-24
• Gelation Behavior of 2<i>H</i>-Chromene <i>N</i>-Acylamino Acid Conjugates
  作者：Alan R. Katritzky、Rajeev Sakhuja、Levan Khelashvili、Karem Shanab

  DOI：10.1021/jo900066m

  日期：2009.4.17

  [GRAPHICS]2H-Chromene-based conjugates of N-acyl-1,omega-amino acids (5, 9a-f, 14a-f) of natural amino acids (10a,b) and of dipeptide (10c) are prepared (60-97%) by N-acylbenzotriazole methodology in aqueous media at 20 degrees C. Gelation properties of the corresponding sodium salts in DMF and DMSO are generalized with respect to an increase or decrease in the chain length of the spacer.