N-cinnamoyl cinnamamide | 26091-02-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N-cinnamoyl cinnamamide
• 英文别名: trans-cinnamimid；di-trans-cinnamoyl-amine；(E)-3-phenyl-N-[(E)-3-phenylprop-2-enoyl]prop-2-enamide
• CAS: 26091-02-1
• 化学式: C₁₈H₁₅NO₂
• 分子量: 277.323
• InChiKey: XGZFCQHYJLUTCV-PHEQNACWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-苯基-2-丙烯酰氯 在 吡啶 、 氯仿 作用下， 生成 N-cinnamoyl cinnamamide 、 tri-trans-cinnamoyl-amine
  参考文献：
  名称：

  The Diacylation of Amides by Acyl Chloride—Pyridine Compounds

  摘要：

  DOI：

  10.1021/ja01156a115

文献信息

• [EN] VARIOLIN DERIVATIVES AS ANTI-CANCER AGENTS<br/>[FR] DERIVES DE VARIOLINE AGISSANT COMME AGENTS ANTI-CANCEREUX
  申请人：PHARMA MAR SA

  公开号：WO2002004447A1

  公开（公告）日：2002-01-17

  The invention provides variolin derivatives of formula (I), wherein: R1 and R2 are each independently selected from the group consisting of H, OH, OR´, SH, SR´, SOR´, SO2R´, NO2, NH2, NHR´, N(R´)2, NHCOR´, N(COR´)2, NHSO2R´, CN, halogen, C(=O)H, C(=O)R´, CO2H, CO2R´, C1-C12 alkyl, C1-C12 haloalkyl, C2-C12 alkenyl, C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; and R3 is selected from the group consisting of H, OH and OMe; wherein the or each group R´ is independently selected from the group consisting of OH, C1-C12 alkyl, C1-C12 haloalkyl, C2-C12 alkenyl, C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted arylalkenyl and substituted or unsubstituted heteroaromatic, and wherein the group R1, R2 or R3 is a group of formula N(R´)2 or N(COR´)2, each of the R´ groups may be the same or different, or the two R´ groups, together with the nitrogen atom to which they are attached, may form a 5-14 membered heterocyclic ring. These compounds display activity against a range of mammalian cancer cell lines. New synthetic routes to new and known variolin compounds, together with novel intermediates, are also disclosed. New antitumour activity of known variolin compounds is also described.

  本发明提供了式（I）的变黄质衍生物，其中：R1和R2各自独立地选自H，OH，OR´，SH，SR´，SOR´，SO2R´，NO2，NH2，NHR´，N（R´）2，NHCOR´，N（COR´）2，NHSO2R´，CN，卤素，C（=O）H，C（=O）R´，CO2H，CO2R´，C1-C12烷基，C1-C12卤代烷基，C2-C12烯基，C2-C12炔基，取代或未取代芳基，取代或未取代芳基烷基和取代或未取代杂环芳基；R3选自H，OH和OMe；其中，每个R´基团独立地选自OH，C1-C12烷基，C1-C12卤代烷基，C2-C12烯基，C2-C12炔基，取代或未取代芳基，取代或未取代芳基烷基，取代或未取代芳基烯基和取代或未取代杂环芳基，且基团R1，R2或R3是公式N（R´）2或N（COR´）2的基团，每个R´基团可以相同或不同，或者两个R´基团与它们连接的氮原子一起形成5-14个成员的杂环环。这些化合物对一系列哺乳动物癌细胞系表现出活性。还公开了新的合成路线，以获得新的和已知的变黄质化合物，以及新的中间体。还描述了已知变黄质化合物的新的抗肿瘤活性。
• Variolin derivatives as anti-cancer agents
  申请人：Morris Charles Jonathan

  公开号：US20050014778A1

  公开（公告）日：2005-01-20

  The invention provides variolin derivatives of formula (I), wherein: R 1 and R 2 are each independently selected from the group consisting of H, OH, OR, SH, SR, SOR, SO 2 R, NO 2 , NH 2 , NHR, N(R) 2 , NHCOR, N(COR) 2 , NHSO 2 R, CN, halogen, C(═O)H, C(═O)R, CO 2 H, CO 2 R, C 1 -C 12 alkyl, C 1 -C 12 haloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; and R 3 is selected from the group consisting of H, OH and OMe; wherein the or each group R is independently selected from the group consisting of OH, C 1 -C 12 alkyl, C 1 -C 12 haloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted or unsubstituted aryl, substituted unsubstituted aralkyl, substituted or unsubstituted arylalkenyl and substituted or unsubstituted heteroaromatic, and wherein the group R 1 , R 2 or R 3 is a group of formula N(R) 2 or N(COR) 2 , each of the R groups may be the same or different, or the two R groups, together with the nitrogen atom to which they are attached, may form a 5-14 membered heterocyclic ring. These compounds display activity against a range of mammalian cancer cell lines. New synthetic routes to new and known variolin compounds, together with novel intermediates, are also disclosed. New antitumour activity of known variolin compounds is also described.

  本发明提供了式（I）的variolin衍生物，其中：R1和R2分别选择自H，OH，OR，SH，SR，SOR，SO2R，NO2，NH2，NHR，N（R）2，NHCOR，N（COR）2，NHSO2R，CN，卤素，C（═O）H，C（═O）R，CO2H，CO2R，C1-C12烷基，C1-C12卤代烷基，C2-C12烯基，C2-C12炔基，取代或未取代芳基，取代或未取代芳基烷基和取代或未取代杂环芳；而R3选择自H，OH和OMe；其中每个R基分别选择自OH，C1-C12烷基，C1-C12卤代烷基，C2-C12烯基，C2-C12炔基，取代或未取代芳基，取代或未取代芳基烷基，取代或未取代芳基烯基和取代或未取代杂环芳基，并且其中的R1，R2或R3是式N（R）2或N（COR）2的基团，每个R基可以相同或不同，或者两个R基与它们附着的氮原子一起形成5-14个成员的杂环环。这些化合物对一系列哺乳动物癌细胞系表现出活性。还披露了新的合成路线以制备新的和已知的variolin化合物，以及新的中间体。还描述了已知variolin化合物的新的抗肿瘤活性。
• Optical recording medium and porphycene compound
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP1180765A1

  公开（公告）日：2002-02-20

  A recordable optical recording medium of this invention capable of good recording and reproduction with a laser at wavelengths of 300 to 500 nm and/or 500 to 700 nm comprises at least one porphycene compounds optionally chelated with a metal in its recording layer.

  本发明的一种可记录光学记录介质，能用波长为 300 至 500 纳米和/或 500 至 700 纳米的激光进行良好的记录和复制，其记录层中至少包含一种可选择与金属螯合的卟吩化合物。
• BENZBISAZOLE COMPOUND AND OPTICAL RECORDING MEDIUM CONTAINING THE COMPOUND
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1245571A1

  公开（公告）日：2002-10-02

  An optical recording medium having an organic dye layer as a recording layer on a substrate, wherein at least one benzobisazole-based compound represented by a general formula (1) is contained in the recording layer: (wherein substituents X and Y each independently represent an aryl group or a heteroaryl group, rings A and B each independently represent an oxazole ring or a thiazole ring, and Q1 and Q2 each independently represent a hydrogen atom, a halogen atom or an alkyl group, with a proviso that, aryl group(s) or heteroaryl group(s) represented by the substituents X and Y each independently may be substituted by a halogen atom, a hydroxyl group, a cyano group, an amino group or a substituted or unsubstituted alkyl, aralkyl, aryl, alkenyl, alkoxy, aralkyloxy, aryloxy, alkenyloxy, alkylthio, aralkylthio, arylthio, alkenylthio, mono-substituted amino, di-substituted amino, acyl, alkoxycarbonyl, aralkyloxycarbonyl, aryloxycarbonyl, alkenyloxycarbonyl, mono-substituted aminocarbonyl, di-substituted aminocarbonyl, acyloxy or heterocyclic ring group).

  一种光学记录介质，在基底上具有作为记录层的有机染料层，其中记录层中含有至少一种由通式(1)表示的苯并异噁唑基化合物： (其中取代基 X 和 Y 各自独立地代表芳基或杂芳基，环 A 和 B 各自独立地代表噁唑环或噻唑环，以及 Q1 和 Q2 各自独立地代表氢原子、卤素原子或烷基，但条件是，取代基 X 和 Y 各自独立地代表的芳基或杂芳基可被卤素原子取代、羟基、氰基、氨基或取代或未取代的烷基、烷基、芳基、烯基、烷氧基、烷氧基、芳氧基、烯氧基、烷硫基、烷硫基、芳硫基、芳硫基、烯硫基、单取代氨基、二取代氨基、酰基、烷氧基羰基、烷氧基羰基、芳氧基羰基、芳氧基羰基、烯氧基羰基、单取代氨基羰基、二取代氨基羰基、酰氧基或杂环基）。
• Optical recording medium and novel azaporphyrin compound
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1262966A2

  公开（公告）日：2002-12-04

  An optical recording medium having a recording layer which contains at least one compound selected from the group consisting of mono-, di-, and triazaporphyrin compounds optionally in the form of a metal complex; or an optical recording medium comprising a substrate and formed thereon at least a recording layer containing an organic dye as a main component, characterized in that the organic dye has a first maximum value of absorption at a wavelength λ1 of 400 nm or less in the absorption spectrum and has a second maximum value of absorption at a longer-wavelength side than the λ1, and a wavelength band wherein the refractive index (n) and the absorption coefficient (k) of the above organic dye satisfy n ≥ 1.90 and 0.03 ≤ k ≤ 0.30.

  一种光学记录介质，其记录层含有至少一种选自由金属络合物形式的单氮杂卟啉、二氮杂卟啉和三氮杂卟啉化合物组成的组中的化合物；或一种光学记录介质，包括基底和在基底上形成的至少含有一种有机染料作为主要成分的记录层，其特征在于，该有机染料在吸收光谱中波长λ1为400纳米或更小的波长处具有第一最大吸收值，并且在比λ1更长的波长侧具有第二最大吸收值，以及上述有机染料的折射率(n)和吸收系数(k)满足n≥1.90 和 0.03 ≤ k ≤ 0.30。