5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine | 645420-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine
• 英文别名: BPIP；5H-Imidazo[4,5-c]pyridine, 5-[(4-bromophenyl)methyl]-2-phenyl-；5-[(4-bromophenyl)methyl]-2-phenylimidazo[4,5-c]pyridine
• CAS: 645420-70-8
• 化学式: C₁₉H₁₄BrN₃
• 分子量: 364.244
• InChiKey: BAONJJYITSLFLE-UHFFFAOYSA-N

物化性质

• 熔点：
  212-214 °C(Solv: isopropyl ether (108-20-3); ethyl acetate (141-78-6))
• 沸点：
  465.9±55.0 °C(Predicted)
• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,4-二氨基吡啶 在 sodium hydroxide 、 PPA 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 27.0h， 生成 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine
  参考文献：
  名称：

  Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A new class of pestivirus inhibitors

  摘要：

  A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC50 < 100 nM) and selectivity (SI > 1000) against the pestivirus BVDV (bovine viral diarrhea virus). (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.081

文献信息

• IMIDAZO [1, 2-A] PYRROLO [3, 2-C] PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS
  申请人：Neyts Johan

  公开号：US20100093781A1

  公开（公告）日：2010-04-15

  The present invention relates to a series of novel imidazo[1,2-α]pyrrolo[3,2-c]pyridines (or also named 6H-1,3a,6-Tri-aza-αy-indacenes) and derivatives thereof, according to formula: (I); The present invention also relates to processes for the preparation of imidazo[1,2-α]pyrrolo[3,2-c]pyridines, their use as. a, medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Bovine Viral Diarrhea virus (BVDV).

  本发明涉及一系列新型咪唑[1,2-α]吡咯并[3,2-c]吡啶（或称为6H-1,3a,6-三氮杂-α-吲哚烯）及其衍生物，其化学式如下：（I）；本发明还涉及制备咪唑[1,2-α]吡咯并[3,2-c]吡啶的方法，它们作为药物的用途，用于治疗或预防病毒感染以及用于制造用于治疗或预防病毒感染的药物，特别是用于感染属于黄病毒科家族的病毒，更好地用于治疗或预防感染牛病毒性腹泻病毒（BVDV）的感染。
• Viral inhibitors
  申请人：Neyts Johan

  公开号：US20050239821A1

  公开（公告）日：2005-10-27

  The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine derivative having the general formula (Z): (formula). The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula and their use as a medicine or to treat or prevent viral infections.

  本发明涉及一种用于治疗或预防病毒感染的药物组合物，其包括至少一种具有通式（Z）的咪唑并[4,5-c]吡啶衍生物作为活性成分。本发明还涉及根据上述通式制备化合物的方法以及它们作为药物或用于治疗或预防病毒感染的用途。
• VIRAL INHIBITORS
  申请人：NEYTS Johan

  公开号：US20100004281A1

  公开（公告）日：2010-01-07

  The present invention relates to imidazo[4,5-c]pyridine compounds and pharmaceutical compositions for the treatment or prevention of viral infections, wherein the imidazo[4,5-c]pyridine compounds have the formula:

  本发明涉及咪唑并[4,5-c]吡啶化合物和制备其药学组合物用于治疗或预防病毒感染，其中咪唑并[4,5-c]吡啶化合物的化学式为：
• IMIDAZO[1,2-A]PYRROLO[3,2-C]PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS
  申请人：Katholieke Universiteit Leuven

  公开号：EP2125807A2

  公开（公告）日：2009-12-02
• ANTIVIRAL EPICATECHINS, EPICATECHIN OLIGOMERS, OR THIOLATED EPICATECHINS FROM THEOBROMA CACAO FOR TREATMENT OF GENITAL WARTS
  申请人：PRESTON Daniel

  公开号：US20110218241A1

  公开（公告）日：2011-09-08

  Epicatechins, Epicatechin Oligomers, or Thiolated Epicatechins are applied (A) directly to a genital wart in the form of a cream, ointment, paste or solution, (B) directly to the genital wart wherein such cream, ointment, paste or solution contains as an additional active ingredient a skin permeabilizing agent, (C) following electrosurgical resection or removal of the genital wart in such form of a cream, ointment, paste or solution, (D) following chemical resection or extirpation of the genital wart in such form, (E) following surgical resection or removal of the genital wart in such form, wherein said Epicatechins, Epicatechin Oligomers, or Thiolated Epicatechins both provide antiviral activity against multiple strains of human papilloma virus (HPV) and promote healing following resection polymers contained in a vehicle. Disclosed are the compositions, therapeutical kits containing such composition, methods of treatment using such composition, and methods of enhancing the stability of such composition.