2-((E)-But-2-enyl)-4-hydroxy-3-(2-methoxy-ethyl)-cyclopent-2-enone | 55833-95-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-((E)-But-2-enyl)-4-hydroxy-3-(2-methoxy-ethyl)-cyclopent-2-enone
• CAS: 55833-95-9
• 化学式: C₁₂H₁₈O₃
• 分子量: 210.273
• InChiKey: RMDJTUVTUSLKLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.62
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-((E)-But-2-enyl)-4-hydroxy-3-(2-methoxy-ethyl)-cyclopent-2-enone 在 氨 、 lithium 、 苯酚 作用下， 以 四氢呋喃 为溶剂， 生成 (1S,3S,4S,5S)-4-Butyl-5-(2-methoxy-ethyl)-cyclopentane-1,3-diol
  参考文献：
  名称：

  Cyclopentanones XIV. The synthesis of a prostanoid synthon starting from 3-alkyl-1,2,4-cyclopentanetriones

  摘要：

  Abstract3‐Alkyl‐1,2,4‐cyclopentanetriones can readily be converted to all trans 2,3‐dialkyl‐1,4‐cyclopentanediols. The latter compounds are intermediates for the synthesis of a prostanoid synthon, known as Corey's lactone, when the alkyl substituents contain appropriate functional groups. The conversion of two different sets of side‐chains to readily distinguishable two‐carbon and one‐carbon aldehyde units is described. Extensive 1H‐NMR data are included.

  DOI：

  10.1002/bscb.19750840803
• 作为产物：
  描述：

  4-((E)-But-2-enyl)-5-(2-methoxy-ethyl)-cyclopent-4-ene-1,3-dione 在 溶剂黄146 、 锌 作用下， 以 二氯甲烷 为溶剂， 生成 2-((E)-But-2-enyl)-4-hydroxy-3-(2-methoxy-ethyl)-cyclopent-2-enone
  参考文献：
  名称：

  Cyclopentanones XIV. The synthesis of a prostanoid synthon starting from 3-alkyl-1,2,4-cyclopentanetriones

  摘要：

  Abstract3‐Alkyl‐1,2,4‐cyclopentanetriones can readily be converted to all trans 2,3‐dialkyl‐1,4‐cyclopentanediols. The latter compounds are intermediates for the synthesis of a prostanoid synthon, known as Corey's lactone, when the alkyl substituents contain appropriate functional groups. The conversion of two different sets of side‐chains to readily distinguishable two‐carbon and one‐carbon aldehyde units is described. Extensive 1H‐NMR data are included.

  DOI：

  10.1002/bscb.19750840803

文献信息

• Cyclopentanones XIV. The synthesis of a prostanoid synthon starting from 3-alkyl-1,2,4-cyclopentanetriones
  作者：W. van Brussel、J. van Hooland、P. De Clercq、M. Vandewalle

  DOI：10.1002/bscb.19750840803

  日期：——

  Abstract3‐Alkyl‐1,2,4‐cyclopentanetriones can readily be converted to all trans 2,3‐dialkyl‐1,4‐cyclopentanediols. The latter compounds are intermediates for the synthesis of a prostanoid synthon, known as Corey's lactone, when the alkyl substituents contain appropriate functional groups. The conversion of two different sets of side‐chains to readily distinguishable two‐carbon and one‐carbon aldehyde units is described. Extensive 1H‐NMR data are included.