(E)-2-methoxy-4-(2-(quinolin-2-yl)ethenyl)phenol | 36585-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-2-methoxy-4-(2-(quinolin-2-yl)ethenyl)phenol
• 英文别名: 4'-Hydroxy-3'-methoxystyryl-2-chinolin；4-(trans-2-[2]quinolyl-vinyl)-2-methoxy-phenol；4-(2-[2]quinolyl-vinyl)-2-methoxy-phenol；4-(trans-2-[2]Chinolyl-vinyl)-2-methoxy-phenol；4-(2-[2]Chinolyl-vinyl)-2-methoxy-phenol；Phenol, 2-methoxy-4-(2-quinolinyl)ethenyl-；2-methoxy-4-[(E)-2-quinolin-2-ylethenyl]phenol
• CAS: 36585-48-5
• 化学式: C₁₈H₁₅NO₂
• 分子量: 277.323
• InChiKey: XZOWQMSJRBHFJX-RMKNXTFCSA-N

物化性质

• 沸点：
  458.1±35.0 °C(Predicted)
• 密度：
  1.246±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-2-methoxy-4-(2-(quinolin-2-yl)ethenyl)phenol 、 溴 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Nencki, Chemische Berichte, 1894, vol. 27, p. 1977

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基喹啉 在 盐酸 、 甲醇 、 水 作用下， 生成 (E)-2-methoxy-4-(2-(quinolin-2-yl)ethenyl)phenol
  参考文献：
  名称：

  Notes - Styryl-Type Dyes

  摘要：

  DOI：

  10.1021/jo01095a026

文献信息

• C(sp3)–H functionalization of methyl azaarenes: a calcium-catalyzed facile synthesis of (E)-2-styryl azaarenes and 2-aryl-1,3-bisazaarenes
  作者：Srinivasarao Yaragorla、Garima Singh、Ravikrishna Dada

  DOI：10.1016/j.tetlet.2015.09.035

  日期：2015.10

  Alkaline earth (Ca2+) catalyzed sp(3) C-H functionalization of methyl azaarenes for the synthesis of biologically important (E)-2-styryl azaarenes, 2-aryl-1,3-bisazaarenes and 3,3-bisazaarenyl indolinones has been described. Initially methyl azaarenes react with aryl aldehydes to give beta-hydroxy derivatives, which undergo Ca(II) catalyzed thermodynamic elimination to give the styryl azaarenes in a single step. Similarly it may undergo S(N)1 reaction to give 2-aryl-1,3-bisazaarenes and 3,3-bisazaarenyl indolinones (if isatin used as the electrophile). This green synthetic methodology enjoys the simple reaction procedures, solvent free conditions, step economy, substrate diversity and high yields of the products in short time. (C) 2015 Elsevier Ltd. All rights reserved.
• Styryl Derivatives of 8-Quinolinol
  作者：J. P. PHILLIPS、RICHARD BREESE、EDWARD M. BARRALL

  DOI：10.1021/jo01090a017

  日期：1959.8
• Chiang; Lu, Journal of the Chinese Chemical Society, 1951, vol. 18, p. 198
  作者：Chiang、Lu

  DOI：——

  日期：——
• ANTI-NEURODEGENERATIVE DISEASE AGENT
  申请人：Ohta Hitomi

  公开号：US20120035187A1

  公开（公告）日：2012-02-09

  The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1: wherein in General formula 1, R 1 through R 3 independently represent a hydrogen atom or an appropriate substituent; Z 1 represents a heterocyclic ring and Z 2 represents the same or different heterocyclic or aromatic ring as in Z 1 , wherein the heterocyclic and aromatic rings optionally have a substituent; represents an integer of 0, 1 or 2; p represents an integer of 0 or 1, with the proviso that p is 1 when o is 0 or 2, and p is 0 when o is 1; R 1 and R 2 do not exist when o is 0, while, when p is 0, R 3 does not exist and the binding between the carbon atom to which R 2 binds and Z 2 is a single bond; X 1 − represents an appropriate counter anion and q represents an integer of 1 or 2.
• US4444868A
  申请人：——

  公开号：US4444868A

  公开（公告）日：1984-04-24