ethyl 8-methoxyquinoline-2-carboxylate | 1415319-29-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 8-methoxyquinoline-2-carboxylate
• 英文别名: Ethyl8-methoxyquinoline-2-carboxylate
• CAS: 1415319-29-7
• 化学式: C₁₃H₁₃NO₃
• 分子量: 231.251
• InChiKey: SLNAHEBHRYPRTP-UHFFFAOYSA-N

物化性质

• 沸点：
  372.3±22.0 °C(Predicted)
• 密度：
  1.184±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-乙烯基己内酰胺 、 2-(2-Methoxyphenylimino)-essigsaeureethylester 在 tris(p-bromophenylammoniumyl) hexachloroantimonate 作用下， 以 1,2-二氯乙烷 为溶剂， 以81%的产率得到ethyl 8-methoxyquinoline-2-carboxylate
  参考文献：
  名称：

  Radical cation salt induced Povarov reaction between iminoethyl glyoxylate and N-vinylamides: synthesis of quinoline-2-carboxylate derivatives

  摘要：

  A domino process between iminoethyl glyoxylate and N-vinylamides was achieved under the catalytic radical cation salt induced conditions, producing a series of quinoline-2-carboxylates. N-Vinylamides were involved as an acetylene equivalent. A possible mechanism was proposed to rationalize the formation of the products. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.097

文献信息

• [EN] HYDRAZONE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS D'HYDRAZONE ET LEUR UTILISATION
  申请人：STEIN PHILIP

  公开号：WO2010132615A1

  公开（公告）日：2010-11-18

  The present invention relates to hydrazone compounds of Formula I: (I) and pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3, R4, L1, and L2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I as inhibitors of TRPM5 protein.

  本发明涉及式I的腙化合物：(I)及其药用可接受的盐和立体异构体，其中R1、R2、R3、R4、L1和L2的定义如规范中所述。该发明还涉及将式I的化合物用作TRPM5蛋白的抑制剂。
• Eco-efficient synthesis of 2-quinaldic acids from furfural
  作者：Minghao Li、Xiaohan Dong、Na Zhang、François Jérôme、Yanlong Gu

  DOI：10.1039/c9gc02206f

  日期：——

  through photooxidation of furfural and a consecutive ring-opening alcoholysis; (ii) cyclization of ethyl 4,4-diethoxycrotonate with aniline, and (iii) hydrolysis of the generated ethyl quinaldate. This new method not only avoids the use of toxic potassium cyanide but also meets many salient features of green chemistry, such as the use of bio-based feedstocks, environmentally benign metal-free conditions and

  喹啉酸是重要的精细化学品。如今，合成喹啉酸的工业方法严重依赖于基于Reissert反应建立的三步法，但是该过程涉及使用剧毒的氰化钾。本文实现了4,4-二乙氧基巴豆酸乙酯对苯胺的新型环化反应，得到的喹啉乙酯收率高。基于该反应，开发了一种生态高效的制备喹啉酸的方法，该方法涉及以下三个步骤：（i）通过糠醛的光氧化和连续的开环醇解合成4,4-二乙氧基巴豆酸乙酯；（ii）用苯胺将4，4-二乙氧基巴豆酸乙酯环化，和（iii）产生的喹啉酸乙酯水解。
• Radical cation salt induced Povarov reaction between iminoethyl glyoxylate and N-vinylamides: synthesis of quinoline-2-carboxylate derivatives
  作者：Xiaodong Jia、Chang Qing、Congde Huo、Fangfang Peng、Xicun Wang

  DOI：10.1016/j.tetlet.2012.10.097

  日期：2012.12

  A domino process between iminoethyl glyoxylate and N-vinylamides was achieved under the catalytic radical cation salt induced conditions, producing a series of quinoline-2-carboxylates. N-Vinylamides were involved as an acetylene equivalent. A possible mechanism was proposed to rationalize the formation of the products. (C) 2012 Elsevier Ltd. All rights reserved.