sodium salt of 3,5-dimethyl-N-ethyl-N-(2-hydroxy-3-sulfopropyl)aniline | 82692-97-5

• 物质功能分类: 生物化工 - 生化试剂 - 生物染料
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sodium salt of 3,5-dimethyl-N-ethyl-N-(2-hydroxy-3-sulfopropyl)aniline
• 英文别名: N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethylanilinesodium salt；MAOS；Sodium salt of N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethylaniline；n-Ethyl-n-(2-hydroxy-3-sulfopropyl)-3,5-dimethylaniline sodium salt monohydrate；sodium;3-(N-ethyl-3,5-dimethylanilino)-2-hydroxypropane-1-sulfonate
• CAS: 82692-97-5
• 化学式: C₁₃H₂₀NO₄S*Na
• 分子量: 309.362
• InChiKey: HLXGRHNZZSMNRX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.96
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2922199090
• 危险性防范说明：
  P501,P270,P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313,P301+P312+P330
• 危险性描述：
  H302,H315,H319
• 储存条件：
  室温

制备方法与用途

MAOS是一种改进的Trinder试剂，可用作显色探针来测定H₂O₂。其检测结果强烈依赖于反应介质的pH值。

反应信息

• 作为反应物：
  描述：

  4-氨基安替比林 、 sodium salt of 3,5-dimethyl-N-ethyl-N-(2-hydroxy-3-sulfopropyl)aniline 在 copper(II) perchlorate 作用下， 以 乙腈 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Colorimetric signaling of Cu(II) ions by oxidative coupling of anilines with 4-aminoantipyrine

  摘要：

  Selective Cu2+ signaling by the oxidative coupling of anilines with 4-aminoantipyrine was investigated. The Cu2+-assisted reaction between N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethylaniline sodium salt and 4-aminoantipyrine resulted in the pronounced color change from colorless to bluish green, with a detection limit of 2.1 x 10(-6) M in 90% aqueous acetonitrile. Furthermore, selective Cu2+ signaling was not affected by the presence of common metal ions as background. The practical utility of this system for the determination of Cu2+ was successfully demonstrated using a convenient chromogenic test strip. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.07.091
• 作为产物：
  描述：

  sodium 3-chloro-2-hydroxypropane-sulfonate 、 (3,5-二甲基苯基)-乙基胺 在 sodium hydroxide 作用下， 以 水 、 异丙醇 为溶剂， 反应 3.0h， 以68%的产率得到sodium salt of 3,5-dimethyl-N-ethyl-N-(2-hydroxy-3-sulfopropyl)aniline
  参考文献：
  名称：

  Tamaoku, Katsumi; Ueno, Keiyu; Akiura, Kayoko, Chemical and pharmaceutical bulletin, 1982, vol. 30, # 7, p. 2492 - 2497

  摘要：

  DOI：

文献信息

• Water-soluble methylenebis(dialkylaniline) derivatives and application
  申请人：Dojindo Laboratories

  公开号：US05264622A1

  公开（公告）日：1993-11-23

  Novel water-soluble methylenebis(dialkylaniline) derivatives of the following general formula and salts thereof are disclosed. They are useful as dye-forming substances in quantitative determination of peroxides in the copresence of peroxidase or the like. ##STR1## In the formula, R.sub.1 is hydrogen or a substituent selected from lower alkyl and C.sub.2-3 sulfoalkyl or hydroxysulfoalkyl; R.sub.2 is C.sub.2-3 sulfoalkyl or hydroxysulfoalkyl; and R.sub.3 is lower alkyl.

  本发明公开了以下通式的新型水溶性亚甲基双(二烷基苯胺)衍生物及其盐。它们在过氧化物酶等存在下的过氧化物定量测定中作为染料形成物质是有用的。 ##STR1## 在该式中，R.sub.1是氢或从低级烷基和C.sub.2-3磺基烷基或羟基磺基烷基中选择的取代基；R.sub.2是C.sub.2-3磺基烷基或羟基磺基烷基；以及R.sub.3是低级烷基。
• TEST PIECE FOR ASSAYING HIGH DENSITY LIPOPROTEIN (HDL) CHOLESTEROL
  申请人：ARKRAY, Inc.

  公开号：EP1342792A1

  公开（公告）日：2003-09-10

  The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer (2) is formed on a support (1), and an enzyme reagent for measuring cholesterol, a first surfactant that makes a solubility of a high-density lipoprotein (HDL) higher than that of a lipoprotein other than the HDL, and a second surfactant that inhibits the lipoprotein other than the HDL from dissolving are contained in the reagent layer (2).

  本发明涉及一种结构简单的测试片，通过该测试片，只需少量标本即可轻松测量高密度脂蛋白胆固醇。 在支架（1）上形成试剂层（2），试剂层（2）中含有用于测量胆固醇的酶试剂、使高密度脂蛋白（HDL）的溶解度高于高密度脂蛋白以外的脂蛋白的溶解度的第一种表面活性剂以及抑制高密度脂蛋白以外的脂蛋白溶解的第二种表面活性剂。
• Dry test strip and method for measuring creatinine
  申请人：ARKRAY, Inc.

  公开号：EP2518501A2

  公开（公告）日：2012-10-31

  A dry test strip for measuring creatinine (1) comprises: a support (2); a reagent layer (4) that is disposed on the support (2); a reagent holding layer (5) that is disposed on the reagent layer (4); and a connection layer (6) that is composed of an adhesive which adhesively bonds the reagent layer (4) to the reagent holding layer (5) and is formed in spot form, wherein the reagent layer (4) contains creatininase and 4-aminoantipyrine; the reagent holding layer (5) contains creatinase, sarcosine oxidase, peroxidase, and N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline; and the connection layer (6) delays arrival of a liquid sample spot-deposited on the reagent holding layer (5) at the reagent layer (4).

  一种用于测量肌酐的干试纸（1）包括支座（2）；试剂层（4），设置在支座（2）上；试剂保持层（5），设置在试剂层（4）上；以及连接层（6），由粘合剂组成，粘合剂将试剂层（4）粘合到试剂保持层（5）上并形成点状，其中试剂层（4）包含肌酐酶和 4-氨基安替比林；试剂保持层（5）含有肌酐酶、肌氨酸氧化酶、过氧化物酶和 N-乙基-N-（2-羟基-3-磺丙基）-3,5-二甲氧基苯胺；以及连接层（6）可延迟点状沉积在试剂保持层（5）上的液体样品到达试剂层（4）。
• SYSTEM AND METHOD FOR DETERMINING A HEALTH CONDITION OF THE LIVER OF A SUBJECT
  申请人：Echosens

  公开号：EP3939514A1

  公开（公告）日：2022-01-19

  A system (1) and method for determining a health condition of the liver of a subject, the system including an elastography device (2), a blood-test reader (3) and an associated blood-test disposable (10), the disposable including a capillary tube for collecting a capillary blood sample from the subject and including reagents appropriate to detect at least one liver enzyme in the blood sample, the blood-test reader being operatively connected to the elastography device, and a control and processing system (4), configured to control the elastography device and the blood test reader and to determine the health condition of the liver of the subject, taking into account both a value of at least one mechanical parameter measured by the elastography device and a value of the concentration of the at least one liver enzyme.

  一种用于确定受试者肝脏健康状况的系统（1）和方法，该系统包括一个弹性成像装置（2）、一个血液测试读取器（3）和一个相关的一次性血液测试装置（10），一次性血液测试装置包括一个毛细管，用于收集受试者的毛细管血样，并包括适合检测血样中至少一种肝酶的试剂、血液检测读取器与弹性成像设备操作性连接，以及控制和处理系统（4），其配置用于控制弹性成像设备和血液检测读取器，并根据弹性成像设备测量的至少一个机械参数值和至少一种肝酶的浓度值确定受试者肝脏的健康状况。
• Test piece for measuring high-density lipoprotein (HDL) cholesterol
  申请人：Tamura Hiroshi

  公开号：US20050250165A1

  公开（公告）日：2005-11-10

  The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer ( 2 ) is formed on a support ( 1 ), and an enzyme reagent for measuring cholesterol, a first surfactant that makes a solubility of a high-density lipoprotein (HDL) higher than that of a lipoprotein other than the HDL, and a second surfactant that inhibits the lipoprotein other than the HDL from dissolving are contained in the reagent layer ( 2 ).

  本发明涉及一种结构简单的测试片，通过这种测试片，只需少量标本即可轻松测量高密度脂蛋白胆固醇。 试剂层 ( 2 ) 上形成一个试剂层 ( 1 )上形成试剂层( 2 )，试剂层( 2 )中含有用于测量胆固醇的酶试剂、使高密度脂蛋白（HDL）的溶解度高于高密度脂蛋白以外的脂蛋白的溶解度的第一种表面活性剂和抑制高密度脂蛋白以外的脂蛋白溶解的第二种表面活性剂。 2 ).