4-(2-phenylquinolin-4-yl)-carbonylmorpholine | 88067-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(2-phenylquinolin-4-yl)-carbonylmorpholine
• 英文别名: Morpholine, 4-[(2-phenyl-4-quinolinyl)carbonyl]-；morpholin-4-yl-(2-phenylquinolin-4-yl)methanone
• CAS: 88067-73-6
• 化学式: C₂₀H₁₈N₂O₂
• mdl: MFCD00249842
• 分子量: 318.375
• InChiKey: DTVPHNNHIIYMME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  mercury(II) diacetate 、 4-(2-phenylquinolin-4-yl)-carbonylmorpholine 、 lithium chloride 以 乙醇 为溶剂， 反应 16.0h， 以55%的产率得到
  参考文献：
  名称：

  X-ray structure of an amide-appended chloromercurated derivative of 2-phenylquinoline

  摘要：

  Reaction of the morpholine amide derivative of 2-phenyl-4-quinolinecarboxylic acid with mercury(II) acetate and lithium chloride results in chloromercuration at the ortho position on the phenyl ring; the complex was characterised by ESI mass spectrometry and an X-ray structure determination.

  DOI：

  10.1134/s0022476615050182
• 作为产物：
  描述：

  2-苯基-4-喹啉羧酸 在 氯化亚砜 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 121.0h， 生成 4-(2-phenylquinolin-4-yl)-carbonylmorpholine
  参考文献：
  名称：

  X-ray structure of an amide-appended chloromercurated derivative of 2-phenylquinoline

  摘要：

  Reaction of the morpholine amide derivative of 2-phenyl-4-quinolinecarboxylic acid with mercury(II) acetate and lithium chloride results in chloromercuration at the ortho position on the phenyl ring; the complex was characterised by ESI mass spectrometry and an X-ray structure determination.

  DOI：

  10.1134/s0022476615050182

文献信息

• Pharmaceutical compositions containing naphthalene-and
  申请人：Rhone-Poulenc Sante

  公开号：US04684652A1

  公开（公告）日：1987-08-04

  Compounds of the formula: ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, phenyl, C.sub.3-6 cycloalkyl, phenylalkyl, cycloalkyl-alkyl or ##STR2## R.sub.3 and R.sub.4 being H or alkyl, R.sub.5 being alkenyl or alkynyl, and the sum of the carbon atoms in R.sub.3, R.sub.4 and R.sub.5 being 2 to 5, R.sub.2 is as defined for R.sub.1 and may also represent ##STR3## in which n is 0, 1, 2 or 3, it also being possible for R.sub.1 and R.sub.2 to form, with the nitrogen atom to which they are attached, a 5-, 6- or 7-membered heterocyclic radical which can contain another hetero-atom chosen from O and N and which can carry 1 or 2 substituents, Z is phenyl, pyridinyl, thienyl, thiazol-2-yl or substituted phenyl, X and R.sub.0 are H, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, nitro or CF.sub.3, A represents N or CH and E represents N or CH, some of which are known compounds, are therapeutically useful compounds useful in the treatment of anxiety states or of pulmonary, renal, circulatory or cardiovascular disorders.

  公式中的化合物：##STR1## 其中R.sub.1是C.sub.1-6烷基，苯基，C.sub.3-6环烷基，苯基烷基，环烷基-烷基或##STR2## R.sub.3和R.sub.4为H或烷基，R.sub.5为烯基或炔基，且R.sub.3，R.sub.4和R.sub.5中碳原子的总和为2至5，R.sub.2的定义与R.sub.1相同，也可以表示为##STR3## 其中n为0、1、2或3，R.sub.1和R.sub.2也可以与它们所连接的氮原子形成一个5-、6-或7-成员的杂环基团，该杂环基团可以含有另一个来自O和N的杂原子，并且可以携带1个或2个取代基，Z是苯基，吡啶基，噻吩基，噻唑-2-基或取代的苯基，X和R.sub.0是H，卤素，C.sub.1-3烷基，C.sub.1-3烷氧基，硝基或CF.sub.3，A代表N或CH，E代表N或CH，其中一些是已知的化合物，是有治疗焦虑状态或肺、肾、循环或心血管障碍的药用化合物。
• Cinchophen Analogues as Potential CNS Agents
  作者：A. Kar

  DOI：10.1002/jps.2600720931

  日期：1983.9

  Several amides of cinchophen were prepared and evaluated as CNS agents. Compounds III, VII, XII, XIII, and XIV exhibited analgesic activity while I, III, and XIV acted as CNS depressants.

  制备了几种噻吩甲酰胺，并作为中枢神经系统药物进行了评估。化合物III，VII，XII，XIII和XIV表现出止痛活性，而化合物I，III和XIV充当中枢神经系统抑制剂。
• US4684652A
  申请人：——

  公开号：US4684652A

  公开（公告）日：1987-08-04
• US4711890A
  申请人：——

  公开号：US4711890A

  公开（公告）日：1987-12-08
• X-ray structure of an amide-appended chloromercurated derivative of 2-phenylquinoline
  作者：C. -Y. Lin、W. Henderson、B. K. Nicholson

  DOI：10.1134/s0022476615050182

  日期：2015.9

  Reaction of the morpholine amide derivative of 2-phenyl-4-quinolinecarboxylic acid with mercury(II) acetate and lithium chloride results in chloromercuration at the ortho position on the phenyl ring; the complex was characterised by ESI mass spectrometry and an X-ray structure determination.