S-(p-bromophenacyl)diethyldithiocarbamate | 17665-47-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: S-(p-bromophenacyl)diethyldithiocarbamate
• 英文别名: 2-(4-Bromophenyl)-2-oxoethyl diethyldithiocarbamate；[2-(4-bromophenyl)-2-oxoethyl] N,N-diethylcarbamodithioate
• CAS: 17665-47-3
• 化学式: C₁₃H₁₆BrNOS₂
• 分子量: 346.312
• InChiKey: OZSXZRLHMYUURE-UHFFFAOYSA-N

物化性质

• 沸点：
  434.4±55.0 °C(Predicted)
• 密度：
  1.408±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  77.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  S-(p-bromophenacyl)diethyldithiocarbamate 、 对溴苯肼 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 S-[5-bromo-2-(p-bromophenyl)indolyl-3]diethyldithiocarbamate
  参考文献：
  名称：

  Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells

  摘要：

  Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.03.110
• 作为产物：
  描述：

  sodium N,N-diethyldithiocarbamate 、 2,4'-二溴苯乙酮 以68%的产率得到S-(p-bromophenacyl)diethyldithiocarbamate
  参考文献：
  名称：

  New derivatives of indole. Synthesis of s-(indolyl-3) diethyl dithiocarbamates

  摘要：

  DOI：

  10.1007/bf02291655

文献信息

• Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells
  作者：Igor V. Magedov、Florence Lefranc、Liliya V. Frolova、Laetitia Moreno Y. Banuls、Amanda S. Peretti、Snezna Rogelj、Véronique Mathieu、Robert Kiss、Alexander Kornienko

  DOI：10.1016/j.bmcl.2013.03.110

  日期：2013.6

  Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses. (C) 2013 Elsevier Ltd. All rights reserved.
• New derivatives of indole. Synthesis of s-(indolyl-3) diethyl dithiocarbamates
  作者：N. M. Przheval'skii、I. V. Magedov、V. N. Drozd

  DOI：10.1007/bf02291655

  日期：1997.12