2-Methyl-acrylic acid 2,2,6,6-tetramethyl-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethoxy)-piperidin-4-yl ester | 869812-08-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: 2-Methyl-acrylic acid 2,2,6,6-tetramethyl-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethoxy)-piperidin-4-yl ester
• 英文别名: [2,2,6,6-tetramethyl-1-[[(1S,2R,6R,8R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methoxy]piperidin-4-yl] 2-methylprop-2-enoate
• CAS: 869812-08-8
• 化学式: C₂₅H₄₁NO₈
• 分子量: 483.602
• InChiKey: JHEQDAHIWKVYEP-WVXKDWSHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  84.9
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4-(tert-butyldimethylsilyloxy)-2,2,6,6-tetramethylpiperidinyloxy 在 4-二甲氨基吡啶 、 四丁基氟化铵 、 三正丁基氢锡 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 苯 为溶剂， 反应 39.3h， 生成 2-Methyl-acrylic acid 2,2,6,6-tetramethyl-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethoxy)-piperidin-4-yl ester
  参考文献：
  名称：

  Strategies for the Generation of Molecularly Imprinted Polymeric Nitroxide Catalysts

  摘要：

  [GRAPHICS]Two strategies for preparing catalytically active molecularly imprinted nitroxide-containing polymers are outlined. Both strategies rely upon the thermal rearrangement chemistry of tertiary amine N-oxides. To this end, several polymers were prepared and the polymeric nitroxides were revealed by oxidation with m-CPBA. All of the resulting polymeric catalysts proved to be competent mediators of the oxidation of alcohols.

  DOI：

  10.1021/ol051749n

文献信息

• Strategies for the Generation of Molecularly Imprinted Polymeric Nitroxide Catalysts
  作者：Christopher D. Anderson、Kenneth J. Shea、Scott D. Rychnovsky

  DOI：10.1021/ol051749n

  日期：2005.10.1

  [GRAPHICS]Two strategies for preparing catalytically active molecularly imprinted nitroxide-containing polymers are outlined. Both strategies rely upon the thermal rearrangement chemistry of tertiary amine N-oxides. To this end, several polymers were prepared and the polymeric nitroxides were revealed by oxidation with m-CPBA. All of the resulting polymeric catalysts proved to be competent mediators of the oxidation of alcohols.