N-isobutyryl deoxyguanosine | 93635-99-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N-isobutyryl deoxyguanosine
• 英文别名: [(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl 2-methylpropanoate
• CAS: 93635-99-5
• 化学式: C₁₄H₁₉N₅O₅
• 分子量: 337.335
• InChiKey: SXSMDQMWBBHTKH-DJLDLDEBSA-N

物化性质

• 密度：
  1.71±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  141
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  三乙胺盐酸盐 、 2'-deoxyguanosine 在 sodium methylate 作用下， 以 甲醇 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-isobutyryl deoxyguanosine
  参考文献：
  名称：

  Protected deoxyadenosines and deoxyguanosines

  摘要：

  通过酰化相应的脱氧腺苷或脱氧鸟苷的羟基和外环氨基团，形成3'-、5'-O-酰基、N-酰基脱氧核糖核苷，然后选择性地去除羟基上的酰基，形成N-酰基脱氧腺苷或N-酰基脱氧鸟苷的制备过程已被披露。

  公开号：

  US20030162957A1

文献信息

• COMPOUNDS FOR TREATING BACTERIAL INFECTIONS
  申请人：Glaser Gad

  公开号：US20110086813A1

  公开（公告）日：2011-04-14

  The present invention relates to a novel class of guanine nucleotide analogs which inhibit RelA and Relseq synthetic activity and which possess anti-bacterial activity. The present invention also relates to pharmaceutical compositions that include such compounds, and to methods of use of such compounds or compositions for combating bacteria and treating bacterial infections.

  本发明涉及一类新型鸟嘌呤核苷酸类似物，其抑制RelA和Relseq的合成活性，并具有抗细菌活性。本发明还涉及包括这些化合物的药物组合物，以及利用这些化合物或组合物来对抗细菌和治疗细菌感染的方法。
• C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support
  申请人：——

  公开号：US20010044530A1

  公开（公告）日：2001-11-22

  Immobilized nucleotide primers of this invention include a modified nucleotide tethered to a support substrate through a linking group. In particular, the modified nucleotide is constructed such that the C-5′ end of the nucleotide is tetherable to the linking group and the protected C-3′ end is available for further controlled modification, e.g., addition of other nucleotides in specific sequences to the immobilized nucleotide primer. Additionally, the linking group is of sufficient length to allow the immobilized nucleotide primer to be used to synthesize and screen arrays of oligonucleotides, e.g., enzymatic C-3′ primer extension.

  本发明的固定核苷酸引物包括通过连接基团固定在支撑基质上的修饰核苷酸。特别是，修饰核苷酸构建为核苷酸的C-5'末端可连接到连接基团，而受保护的C-3'末端可用于进一步的受控修饰，例如，在固定的核苷酸引物中特定序列的添加其他核苷酸。此外，连接基团的长度足够长，可用于合成和筛选寡核苷酸阵列，例如，酶促C-3'引物延伸。
• Thioether substituted aryl carbonate protecting groups
  申请人：Timar Zoltan

  公开号：US20080146787A1

  公开（公告）日：2008-06-19

  Embodiments of the invention include thioether substituted aryl carbonate protecting groups, and nucleoside monomers protected with thioether substituted aryl carbonate protecting groups. Aspects of the invention further included methods of synthesizing nucleic acids, e.g., oligonucleotides, using such protected nucleoside monomer monomers, as well as nucleic acids produced using methods of the invention and compositions thereof.

  本发明的实施方式包括硫醚取代的芳基碳酸酯保护基，以及使用硫醚取代的芳基碳酸酯保护基保护的核苷单体。本发明的方面还包括使用这种受保护的核苷单体单体合成核酸（例如寡核苷酸）的方法，以及使用本发明的方法合成的核酸及其组成物。
• Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
  申请人：Pro-Neuron, Inc.

  公开号：US20040235782A1

  公开（公告）日：2004-11-25

  The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.

  本发明涉及某些氧杂嘌呤核苷、这些氧杂嘌呤核苷的同系物和酰基衍生物，以及至少含有这些化合物之一的组合物。本发明还涉及通过向动物施用本发明的化合物或组合物来治疗或预防造血障碍和调节造血以及治疗或预防炎症性疾病和细菌感染的方法。
• Interaction detection on several probe arrays
  申请人：Ellinger Thomas

  公开号：US20050147984A1

  公开（公告）日：2005-07-07

  The invention concerns a method for detecting interactions between probe molecules and target molecules, whereby marking target molecules is not required. The invention further concerns probe arrays and kits suited to such a method, as well as a method for production, quality control and standardization of probe arrays.

  本发明涉及一种检测探针分子与靶分子之间相互作用的方法，不需要标记目标分子。本发明还涉及适用于此类方法的探针阵列和试剂盒，以及探针阵列的生产、质量控制和标准化方法。