5-hydroxy-2-methylpent-1-en-3-one | 68843-92-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-hydroxy-2-methylpent-1-en-3-one
• 英文别名: 5-Hydroxy-2-methyl-pent-1-en-3-on；hydroxyethylmethacrylate
• CAS: 68843-92-5
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: SAJQFIMRYKQCMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-hydroxy-2-methylpent-1-en-3-one 、 benzyl 2-diazobut-3-enoate 在 dirhodium tetraacetate 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以71%的产率得到benzyl (Z)-6-methyl-7-oxo-4,5,6,7,8,9-hexahydrooxonine-2-carboxylate
  参考文献：
  名称：

  铑类胡萝卜素引发的O–H插入/醛醇缩合/氧应付级联反应，用于功能性氧杂环丁烷的立体选择性合成

  摘要：

  已开发出一种新颖的重氮级联方法，利用易于获得的β-羟基乙烯基酮和乙烯基重氮酯合成九元恶环。Rh（II）催化的级联反应从卡宾O–H插入开始，然后进行分子内羟醛环化，以提供取代的四氢呋喃中间体，该中间体进行氧-Cope重排，以提供具有完全立体选择性的功能化九元氧杂环。

  DOI：

  10.1021/acs.orglett.6b03229
• 作为产物：
  描述：

  Ethyl (+/-)-3-hydroxy-4-methyl-4-pentenoate 在 manganese(IV) oxide 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 5-hydroxy-2-methylpent-1-en-3-one
  参考文献：
  名称：

  铑类胡萝卜素引发的O–H插入/醛醇缩合/氧应付级联反应，用于功能性氧杂环丁烷的立体选择性合成

  摘要：

  已开发出一种新颖的重氮级联方法，利用易于获得的β-羟基乙烯基酮和乙烯基重氮酯合成九元恶环。Rh（II）催化的级联反应从卡宾O–H插入开始，然后进行分子内羟醛环化，以提供取代的四氢呋喃中间体，该中间体进行氧-Cope重排，以提供具有完全立体选择性的功能化九元氧杂环。

  DOI：

  10.1021/acs.orglett.6b03229

文献信息

• [EN] MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS DE SUBSTANCES ANALOGUES A LA MIGRASTATINE ET LEURS UTILISATIONS
  申请人：CORNELL RES FOUNDATION INC

  公开号：WO2004087672A1

  公开（公告）日：2004-10-14

  In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-RC, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.

  在一方面，本发明提供了包含式(I)化合物的治疗有效量的药物组合物，其中R1-R6，Ra-RC，Q，Y1，Y2和n如本文所述定义，该组合物为用于向受试者给药而配制成，剂量为约0.1 mg/kg至约50 mg/kg体重。在另一方面，本发明提供了一种治疗受试者乳腺癌转移的方法，包括向需要治疗的受试者给药治疗有效量的上述创新组合物以及药用可接受载体、佐剂或车辆。
• Synthesis of vinyl carbonates for use in producing vinyl carbamates
  申请人：Wright Chemical Corporation

  公开号：US06362363B1

  公开（公告）日：2002-03-26

  A method for making a vinyl carbonate represented by the formula (I): CH2═CHOC(O)X1R1  (I) wherein X1 is oxygen or sulfur and R1 is a substituted or an unsubstituted aliphatic alkyl, aryl, aryl alkyl, olefinic, vinyl, or cycloaliphatic group comprises: (a) reacting a compound represented by the formula (II): X2C(O)X1R1  (II)  wherein X2 is a halogen other than fluorine, with a compound represented by the formula (III): M1—F  (III)  wherein M1 is selected from a Group IA metal, in the presence of a first phase transfer catalyst and a first organic solvent, to form a compound represented by the formula (IV): FC(O)X1R1  (IV) and (b) reacting a compound represented by the formula (IV) with a compound represented by the formula (V): CH2═CHOSi(R2)3  (V)  wherein R2 is a substituted or an unsubstituted aliphatic alkyl, aryl, aryl alkyl olefinic, vinyl, or cycloaliphatic group, or any combination thereof, in the presence of a metal salt represented by the formula M2—F wherein M2 is a Group IA metal, a second phase transfer catalyst, and a second organic solvent, to form the compound represented by formula (I).

  一种制备由式(I)表示的乙烯碳酸酯的方法：CH2═CHOC(O)X1R1  (I)其中X1为氧或硫，R1为取代或未取代的脂肪族烷基、芳基、芳基烷基、烯烃、乙烯或环脂肪族基团，包括：(a)将由式(II)表示的化合物进行反应：X2C(O)X1R1  (II)其中X2为氟以外的卤素，与由式(III)表示的化合物进行反应：M1—F  (III)其中M1选自IA族金属，在第一相转移催化剂和第一有机溶剂的存在下，形成由式(IV)表示的化合物：FC(O)X1R1  (IV)和(b)将由式(IV)表示的化合物与由式(V)表示的化合物进行反应：CH2═CHOSi(R2)3  (V)其中R2为取代或未取代的脂肪族烷基、芳基、芳基烷基、烯烃、乙烯或环脂肪族基团，或其任意组合，在金属盐M2—F的存在下，其中M2为IA族金属，第二相转移催化剂和第二有机溶剂，形成由式(I)表示的化合物。
• Electrophoresis gels and cross-linking agents for their preparation
  申请人：The University of Melbourne

  公开号：US20010020079A1

  公开（公告）日：2001-09-06

  Method of separating molecules by providing a cross-linked polymer gel having a cross-linking moiety of the formula 1 wherein X, X′, Y, Z and R 2 are as defined in the specification. A sample containing the molecules to be separated is placed on the gel, and the gel is subjected to a separation technique.

  通过提供具有交联单体的交联聚合物凝胶来分离分子的方法，其中交联单体的结构如下所示，其中X、X′、Y、Z和R2如规范中定义。将含有待分离分子的样品放置在凝胶上，并对凝胶进行分离技术处理。
• Calixarene compound, process for producing the same, intermediate therefor, and composition thereof
  申请人：Nishikubo Tadatomi

  公开号：US20070123736A1

  公开（公告）日：2007-05-31

  A novel calixarene compound, a method for manufacturing the same, an intermediate of the calixarene compound, and a composition comprising the same are provided. The calixarene compound is expected to be useful as an inclusion compound and, if functional groups are introduced, can be used for a curable composition and a photoresist and as an inclusion compound. The calixarene compound is shown by following formula (1): wherein R 1 to R 6 individually represent a substituted or unsubstituted alkylene group having 1 to 8 carbon atoms; X 1 to X 12 individually represent a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, a substituted or unsubstituted alkenyl group having 2 to 10 carbon atoms, a substituted or unsubstituted alkynyl group having 2 to 10 carbon atoms, a substituted or unsubstituted aralkyl group having 7 to 10 carbon atoms, a substituted or unsubstituted alkoxyl group having 1 to 10 carbon atoms, or a substituted or unsubstituted phenoxy group; Z 1 to Z 24 individually represent a hydrogen atom, a group having a polymerizable functional group, a group having an alkali-soluble group, or a substituted alkyl group having an alkyl chain with a 1-8 carbon atom content, or two adjacent Zs in combination represent a substituted or unsubstituted alkylene group having 1 to 8 carbon atoms; q 1 to q 12 individually represent an integer of 0 or 1.

  本发明提供了一种新型的杯芳烃化合物、其制造方法、杯芳烃化合物的中间体以及包含该化合物的组合物。该杯芳烃化合物预计可用作包含化合物，如果引入功能基团，则可用于可固化组合物和光阻，以及作为包含化合物。该杯芳烃化合物由以下公式（1）表示：其中，R1至R6分别表示具有1至8个碳原子的取代或未取代的烷基基团；X1至X12分别表示具有1至10个碳原子的取代或未取代的烷基基团、具有2至10个碳原子的取代或未取代的烯基基团、具有2至10个碳原子的取代或未取代的炔基基团、具有7至10个碳原子的取代或未取代的芳基烷基基团、具有1至10个碳原子的取代或未取代的烷氧基基团或取代或未取代的苯氧基；Z1至Z24分别表示氢原子、具有可聚合功能基团的基团、具有碱溶性基团的基团或具有1-8个碳原子含量的烷基链的取代烷基基团，或两个相邻的Z组合表示具有1至8个碳原子的取代或未取代的烷基基团；q1至q12分别表示0或1的整数。
• ACTIVE LIGHT RAY SENSITIVE OR RADIOACTIVE RAY SENSITIVE RESIN COMPOSITION, AND ACTIVE LIGHT RAY SENSITIVE OR RADIOACTIVE RAY SENSITIVE FILM AND PATTERN FORMING METHOD USING THE SAME
  申请人：KAWABATA Takeshi

  公开号：US20120082939A1

  公开（公告）日：2012-04-05

  An active light ray sensitive or radioactive ray sensitive resin composition which satisfies high sensitivity, high resolution, good pattern configuration, and good line edge roughness at the same time to a great extent, while having sufficiently good outgassing performance during exposure, and an active light ray sensitive or radioactive ray sensitive film formed by using the composition, and a pattern-forming method, are provided. The active light ray sensitive or radioactive ray sensitive resin composition according to the present invention includes a resin (P) containing a repeating unit (A) which decomposes by irradiation with active light ray or radioactive ray to generate an acid, and a repeating unit (C) containing a primary or secondary hydroxyl group.

  提供了一种活性光线敏感或放射线敏感的树脂组合物，其在很大程度上同时满足高灵敏度、高分辨率、良好的图案配置和良好的线边粗糙度，同时在曝光期间具有足够好的排气性能，以及使用该组合物形成的活性光线敏感或放射线敏感薄膜和形成图案的方法。本发明的活性光线敏感或放射线敏感的树脂组合物包括含有重复单元（A）的树脂（P），该重复单元通过活性光线或放射线辐射分解生成酸，并且含有主要或次要羟基的重复单元（C）。