dibutyltin(Acac)2 | 1185-72-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dibutyltin(Acac)2
• 英文别名: dibutyltin bis(acetylacetonate)；dibutyltin acetylacetonate；(Z)-4-[dibutyl-[(Z)-4-oxopent-2-en-2-yl]oxystannyl]oxypent-3-en-2-one
• CAS: 1185-72-4
• 化学式: C₁₈H₃₂O₄Sn
• 分子量: 431.16
• InChiKey: UVDDHYAAWVNATK-VGKOASNMSA-L

物化性质

• 熔点：
  30 °C
• 沸点：
  144 °C(Press: 0.015 Torr)
• 密度：
  1.2493 g/cm3
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  5.05
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methyl-1-piperidine dithiocarbamic acid 、 dibutyltin(Acac)2 以 氯仿 为溶剂， 以90%的产率得到dibutyltin(Acac)(4-methyl-1-piperidinecarbodithioic acid(-H))
  参考文献：
  名称：

  Synthesis, spectroscopy, semiempirical, phytotoxicity, antibacterial, antifungal, and cytotoxicity of diorganotin(IV) complex derived from Bu2Sn(Acac)2 and 4-methyl-1-piperidinecarbodithioic acid

  摘要：

  New diorganotin(IV) derivative of 4-methyl-1-piperidinecarbodithioic acid (4-MePCDTA) have been synthesized by the reaction of dibutyltin(Acac)(2) and ligand acid in a 1: 1 molar ratio in anhydrous chloroform at room temperature. The newly synthesized complex has been characterized by elemental, IR, and multinuclear NMR (H-1 and C-13). The diorganotin(IV) derivative is assessed to adopt distorted octahedral geometry in the solid state, while tetrahedral geometry is exhibited in a solution state. The modeled structure of the reported complex shows severely distorted octahedral geometry around tin. The axial tin carbon bond lengths are 2.15 . The Sn-O bond lengths for coordinated Acac in the equatorial plane are 2.37 and 2.23 , respectively. The complex was also tested for antimicrobial activity against different bacterial and fungal strains, artemia salina cytotoxicity, and plant phytotoxicity. The screening results show that the complex exhibits high antibacterial, antifungal, and artemia salina cytotoxicity and have a potential to be used as drug. Low phytotoxic activity shows that the reported compound can be used as agrochemical. The structure-activity relationship demonstrates that the compound having four-coordinated geometry in the solution state is more toxic.

  DOI：

  10.1134/s1070328410040123
• 作为产物：
  描述：

  4-羟基戊-3-烯-2-酮 、 二正丁基氧化锡 以 苯 为溶剂， 反应 10.0h， 以87%的产率得到dibutyltin(Acac)2
  参考文献：
  名称：

  一种二正丁基双（乙酰丙酮基）锡的合成方法

  摘要：

  本发明公开了一种二正丁基双(乙酰丙酮基)锡的合成方法，包括以下步骤：1)将乙酰丙酮、二正丁基锡化合物和溶剂混合，在无催化剂的作用下，进行回流反应；2)回流反应完成后，冷却至室温，减压蒸馏除去溶剂和未反应的乙酰丙酮，得到产物二正丁基双(乙酰丙酮基)锡。本发明提供了一种全新的适合于工业合成的二正丁基双(乙酰丙酮基)锡的生产方法，该方法工艺简单，对设备要求低，反应条件温和，产率高，易于工业化生产，同时还具有原子经济性高，对环境友好的优点，得到的二正丁基双(乙酰丙酮基)锡产品无溶剂和原料残留，产品质量高。

  公开号：

  CN109134529A
• 作为试剂：
  描述：

  Inositol 、 (1R,2S,5R)-Menthyl chloroformate 在 N-甲基咪唑 、 dibutyltin(Acac)2 作用下， 生成 1-O-(-)-menthoxycarbonyl-myo-inositol 、 1-O-menthyloxycarbonylmyo-inositol
  参考文献：
  名称：

  对映体纯的肌醇衍生物的区域选择性合成。肌醇1,4,5-三磷酸酯的高效合成。

  摘要：

  肌醇的区域选择性1- O-酰化和同时的光学拆分已通过渗碳，使用二正丁基锡-双-乙酰丙酮酸的金属转移，然后再与（-）-薄荷基氯甲酸酯酰化来实现。非对映体纯的1- ø - （ - ） - menthoxycarbonyl-肌醇肌醇1可以用作用于制备生物学上重要的起始材料肌肉在更短的和有效的方式肌醇磷酸盐和糖基磷脂酰肌醇。

  DOI：

  10.1016/s0040-4039(00)74142-6

文献信息

• 一种二正丁基双（乙酰丙酮基）锡的合成方法
  申请人：佛山市元通胶粘实业有限公司

  公开号：CN109134529A

  公开（公告）日：2019-01-04

  本发明公开了一种二正丁基双(乙酰丙酮基)锡的合成方法，包括以下步骤：1)将乙酰丙酮、二正丁基锡化合物和溶剂混合，在无催化剂的作用下，进行回流反应；2)回流反应完成后，冷却至室温，减压蒸馏除去溶剂和未反应的乙酰丙酮，得到产物二正丁基双(乙酰丙酮基)锡。本发明提供了一种全新的适合于工业合成的二正丁基双(乙酰丙酮基)锡的生产方法，该方法工艺简单，对设备要求低，反应条件温和，产率高，易于工业化生产，同时还具有原子经济性高，对环境友好的优点，得到的二正丁基双(乙酰丙酮基)锡产品无溶剂和原料残留，产品质量高。
• Synthesis, spectroscopy, semiempirical, phytotoxicity, antibacterial, antifungal, and cytotoxicity of diorganotin(IV) complex derived from Bu2Sn(Acac)2 and 4-methyl-1-piperidinecarbodithioic acid
  作者：H. N. Khan、S. Ali、S. Shahzadi、S. K. Sharma、K. Qanungo

  DOI：10.1134/s1070328410040123

  日期：2010.4

  New diorganotin(IV) derivative of 4-methyl-1-piperidinecarbodithioic acid (4-MePCDTA) have been synthesized by the reaction of dibutyltin(Acac)(2) and ligand acid in a 1: 1 molar ratio in anhydrous chloroform at room temperature. The newly synthesized complex has been characterized by elemental, IR, and multinuclear NMR (H-1 and C-13). The diorganotin(IV) derivative is assessed to adopt distorted octahedral geometry in the solid state, while tetrahedral geometry is exhibited in a solution state. The modeled structure of the reported complex shows severely distorted octahedral geometry around tin. The axial tin carbon bond lengths are 2.15 . The Sn-O bond lengths for coordinated Acac in the equatorial plane are 2.37 and 2.23 , respectively. The complex was also tested for antimicrobial activity against different bacterial and fungal strains, artemia salina cytotoxicity, and plant phytotoxicity. The screening results show that the complex exhibits high antibacterial, antifungal, and artemia salina cytotoxicity and have a potential to be used as drug. Low phytotoxic activity shows that the reported compound can be used as agrochemical. The structure-activity relationship demonstrates that the compound having four-coordinated geometry in the solution state is more toxic.