ethyl 2-hydroxy-4-(2-methoxyphenyl)-3-nitrobut-3(E)-enoate | 1262022-93-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: ethyl 2-hydroxy-4-(2-methoxyphenyl)-3-nitrobut-3(E)-enoate
• CAS: 1262022-93-4
• 化学式: C₁₃H₁₅NO₆
• 分子量: 281.265
• InChiKey: MINKFZAIUZJSKT-CSKARUKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.24
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  98.9
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  乙醛酸乙酯 、 1-(2-甲氧苯基)-2-硝基乙烯 在 咪唑 、 C₁₅H₁₀F₆N₂OS 作用下， 以 水 、 甲苯 为溶剂， 反应 12.0h， 以78%的产率得到ethyl 2-hydroxy-4-(2-methoxyphenyl)-3-nitrobut-3(E)-enoate
  参考文献：
  名称：

  An efficient Morita–Baylis–Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitrobut-3-enoate derivatives

  摘要：

  An efficient thiourea promoted MBH reaction of various conjugated nitroalkenes with ethyl glyoxylate was developed. The desired multifunctional products, 2-hydroxy-3-nitro-4-aryl/alkylbut-3-enoate derivatives were obtained in good to high chemical yields (56-92%) with DMAP (20 mol%) under solvent-free conditions or imidazole (100 mol%) in the presence of water. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.10.061

文献信息

• An efficient Morita–Baylis–Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitrobut-3-enoate derivatives
  作者：Hsuan-Hao Kuan、Raju Jannapu Reddy、Kwunmin Chen

  DOI：10.1016/j.tet.2010.10.061

  日期：2010.12

  An efficient thiourea promoted MBH reaction of various conjugated nitroalkenes with ethyl glyoxylate was developed. The desired multifunctional products, 2-hydroxy-3-nitro-4-aryl/alkylbut-3-enoate derivatives were obtained in good to high chemical yields (56-92%) with DMAP (20 mol%) under solvent-free conditions or imidazole (100 mol%) in the presence of water. (C) 2010 Elsevier Ltd. All rights reserved.