7-bromo-8-chloroquinoline | 1429790-80-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-bromo-8-chloroquinoline
• 英文别名: 7-Bromo-8-chloroquinoline
• CAS: 1429790-80-6
• 化学式: C₉H₅BrClN
• 分子量: 242.502
• InChiKey: CEYGIBBNXCBDGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  4-cyclopropyl-9-{[2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione 、 7-bromo-8-chloroquinoline 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.42h， 以32%的产率得到(+)-9-{[4-(8-chloro-7-quinolinyl)-2,6-difluorophenyl]methyl}-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione
  参考文献：
  名称：

  [EN] FATTY ACID SYNTHASE INHIBITORS
  [FR] INHIBITEURS DE L'ACIDE GRAS SYNTHASE

  摘要：

  公开了具有化学式（I）的化合物，或其药学上可接受的盐，其中R1、R2、R3、R5、R6、R7、R8、R8a、R9、Y和m在此处被定义，并使用这些化合物的方法。

  公开号：

  WO2013052716A1
• 作为产物：
  描述：

  3-溴-2-氯苯胺 、 甘油 在 硫酸 、 sodium 3-nitrobenzenesulfonate 作用下， 以 水 为溶剂， 反应 2.0h， 以96%的产率得到7-bromo-8-chloroquinoline
  参考文献：
  名称：

  [EN] FATTY ACID SYNTHASE INHIBITORS
  [FR] INHIBITEURS DE L'ACIDE GRAS SYNTHASE

  摘要：

  公开了具有化学式（I）的化合物，或其药学上可接受的盐，其中R1、R2、R3、R5、R6、R7、R8、R8a、R9、Y和m在此处被定义，并使用这些化合物的方法。

  公开号：

  WO2013052716A1

文献信息

• [EN] 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE PIPÉRIDINE 1,4-SUBSTITUÉS
  申请人：CEPHALON INC

  公开号：WO2016205633A1

  公开（公告）日：2016-12-22

  Described herein are 1,4-substituted piperidine compounds according to Formula (I) that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

  本文描述了按照式（I）的1,4-取代哌啶化合物，这些化合物已经表现出作为脂肪酸合成酶抑制剂的活性。本文还描述了含有所述1,4-取代哌啶化合物的药物组合物，以及通过给予所述化合物或药物配方中的一个或多个来治疗由脂肪酸合成酶介导的疾病的方法。本文还描述了合成所述化合物的方法，包括所述的1,4-取代哌啶化合物和在这些合成中有用的合成中间体。
• [EN] SPIROPIPERIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE SPIROPIPÉRIDINE
  申请人：CEPHALON INC

  公开号：WO2018112204A1

  公开（公告）日：2018-06-21

  Described herein are spiropiperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described spiropiperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described spiropiperidine compounds and synthetic intermediates that are useful in those syntheses.

  本文所述的是根据式I的螺哌啶化合物，它们已显示出作为脂肪酸合成酶抑制剂的活性。本文还描述了含有所述螺哌啶化合物的药物组合物，以及通过施用本文所述的一种或多种化合物或药物制剂来治疗由脂肪酸合成酶介导的疾病的方法。本文还描述了合成所述化合物的方法，包括所述螺哌啶化合物及其在那些合成中有用的合成中间体。
• [EN] SUBSTITUTED 4-BENZYL AND 4-BENZOYL PIPERIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 4-BENZYL ET 4-BENZOYL-PIPÉRIDINE SUBSTITUÉS
  申请人：CEPHALON INC

  公开号：WO2016205590A1

  公开（公告）日：2016-12-22

  Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

  本文描述了根据公式I的1,4-取代哌啶化合物，这些化合物已经表现出作为脂肪酸合酶抑制剂的活性。本文还描述了含有所述1,4-取代哌啶化合物的药物组合物。本文还描述了通过给予本文描述的一个或多个化合物或药物配方治疗由脂肪酸合酶介导的疾病的方法。本文还描述了合成所述1,4-取代哌啶化合物以及在这些合成中有用的合成中间体的方法。
• 1,4-substituted piperidine derivatives
  申请人：89BIO LTD

  公开号：US10221135B2

  公开（公告）日：2019-03-05

  Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

  本文描述了根据式 I 的 1,4-取代的哌啶化合物，这些化合物已被证明具有脂肪酸合酶抑制剂的活性。本文还描述了含有所述 1,4-取代哌啶化合物的药物组合物，以及通过施用一种或多种本文所述化合物或药物制剂治疗由脂肪酸合成酶介导的疾病的方法。本文还描述了合成所述化合物的方法，包括所述 1,4-取代的哌啶化合物和用于这些合成的合成中间体。
• Substituted 4-benzyl and 4-benzoyl piperidine derivatives
  申请人：89BIO LTD

  公开号：US10919875B2

  公开（公告）日：2021-02-16

  Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

  本文所述的 1,4-取代的哌啶化合物符合式 I，具有脂肪酸合成酶抑制剂的活性。本文还描述了含有所述 1,4-取代哌啶化合物的药物组合物。本文还描述了通过施用一种或多种本文所述化合物或药物制剂来治疗由脂肪酸合成酶介导的疾病的方法。本文还描述了合成所述 1,4-取代的哌啶化合物和用于这些合成的合成中间体的方法。