methyl 2-((2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methoxy)acetate | 545561-91-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-((2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methoxy)acetate
• 英文别名: (2,3-dihydro-thieno[3,4-b][1,4]dioxin-2-ylmethoxy)-acetic acid methyl ester；Methyl 2-(2,3-dihydrothieno[3,4-b][1,4]dioxin-3-ylmethoxy)acetate
• CAS: 545561-91-9
• 化学式: C₁₀H₁₂O₅S
• 分子量: 244.268
• InChiKey: FQQKPSJEDLWUBV-UHFFFAOYSA-N

物化性质

• 沸点：
  358.6±37.0 °C(Predicted)
• 密度：
  1.297±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  82.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl 2-((2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methoxy)acetate 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 2-((2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methoxy)acetic acid
  参考文献：
  名称：

  In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection

  摘要：

  一个含有3,4-乙烯二氧基噻吩共轭氨基苯丙氨酸的电聚合肽探针被开发用于检测流感病毒的“开启”检测。

  DOI：

  10.1039/c8cc01775a
• 作为产物：
  描述：

  溴乙酸甲酯 、 羟甲基 EDOT 在 sodium hydride 、 sodium iodide 作用下， 以 四氢呋喃 为溶剂， 生成 methyl 2-((2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methoxy)acetate
  参考文献：
  名称：

  In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection

  摘要：

  一个含有3,4-乙烯二氧基噻吩共轭氨基苯丙氨酸的电聚合肽探针被开发用于检测流感病毒的“开启”检测。

  DOI：

  10.1039/c8cc01775a

文献信息

• Direct C–H Arylation Polymerization to form Anionic Water-Soluble Poly(3,4-ethylenedioxythiophenes) with Higher Yields and Molecular Weights
  作者：Hsiao-hua Yu、Hailemichael Ayalew、Tian-lin Wang、Tsai-Hui Wang、Hsiu-Fu Hsu

  DOI：10.1055/s-0037-1611310

  日期：2018.12

  properties of the polymers have been examined. The method gives anionic poly(3,4-ethylenedioxythiophenes) with higher molecular weights than those produced by the previously reported chemical or electrochemical methods. The method was also used to synthesize polymers functionalized with carboxylic acid groups without the need for protection/deprotection steps. The resulting polymers can be processed from

  一种简便且环境友好的 Pd 催化直接 C-H 芳基化聚合 (DAP) 已被开发用于合成阴离子基团官能化 3,4-亚乙基二氧噻吩的均聚物和共聚物，具有高产率（高达 99%）、高分子量和窄的多分散性。已经研究了各种 Pd 催化剂、膦配体和添加剂对聚合物性能的影响。该方法得到的阴离子聚（3,4-亚乙基二氧噻吩）的分子量比以前报道的化学或电化学方法产生的分子量更高。该方法还用于合成用羧酸基团官能化的聚合物，而无需保护/脱保护步骤。所得聚合物可由水或高极性有机溶剂加工而成。我们还展示了无磷化氢，水介导的 Pd 催化的 DAP。阴离子聚（3,4-亚乙基二氧噻吩）在水中稳定，有望用于传感器、药物输送和细胞工程。
• 3,4-Alkylenedioxythiophene compounds and polymers thereof
  申请人：AGFA-GEVAERT

  公开号：US20030176628A1

  公开（公告）日：2003-09-18

  A thiophene compound represented by formula (I): 1 in which A represents a C 1-5 -alkylene bridge; R represents a —R 1 —(C═O)—R 2 group; —R 1 — represents a —R 3 — or —R 4 —X—R 5 — group; R 2 is hydrogen, a hydroxy group, a thiol group, —NR 6 R 7 , —OR 8 or a —SR 9 group; R 3 , R 4 and R 5 are independently an alkylene group or an arylene group; X is a —O—, —S— or ═NR 10 ; R 6 and R 7 are independently hydrogen, an optionally substituted amino group or an optionally substituted alkyl group; R 8 and R 9 are independently an optionally substituted alkyl group (optionally with at least one substituent selected from the group consisting of an alcohol, amide, ether, ester or sulfonate group), an optionally substituted aryl group or a —SiR 11 R 12 R 13 group; R 10 is an alkyl, aryl or acyl group; and R 11 R 12 and R 13 are independently an optionally substituted alkoxy or alkyl group; polymers derived therefrom; a process for polymerizing a thiophene according to formula (I), optionally chemically or electrochemically; and solutions, dispersions, pastes and layers containing polymers derived therefrom.

  一种由公式（I）表示的噻吩化合物：其中A代表C1-5-烷基桥；R代表—R1—（C═O）—R2基团；—R1—代表—R3—或—R4—X—R5—基团；R2为氢、羟基、硫醇基、—NR6R7、—OR8或—SR9基团；R3、R4和R5分别为烷基基团或芳基基团；X为—O—、—S—或═NR10；R6和R7分别为氢、可选取代的氨基基团或可选取代的烷基基团；R8和R9分别为可选取代的烷基基团（可选含有醇、酰胺、醚、酯或磺酸盐基团中的至少一个取代基），可选取代的芳基基团或—SiR11R12R13基团；R10为烷基、芳基或酰基基团；R11、R12和R13分别为可选取代的烷氧基或烷基基团；由此导出的聚合物；根据公式（I）聚合噻吩的过程，可选择化学或电化学；以及含有由此导出的聚合物的溶液、分散体、糊状物和层。
• 3,4-alkylenedioxythiophene compounds and polymers thereof
  申请人：AGFA-GEVAERT

  公开号：EP1321483A1

  公开（公告）日：2003-06-25

  A thiophene compound represented by formula (I): in which A represents a C1-5-alkylene bridge; R represents a -R1-COR2 group; -R1- represents a -R3- or -R4-X-R5- group; R2 is hydrogen, a hydroxy group, a thiol group, -NR6R7, -OR8 or a -SR9 group; R3, R4 and R5 are independently an alkylene group or an arylene group; X is a -O-, -S- or =NR10; R6 and R7 are independently hydrogen, an optionally substituted amino group or an optionally substituted alkyl group; R8 and R9 are independently an optionally substituted alkyl group (optionally with at least one substituent selected from the group consisting of an alcohol, amide, ether, ester or sulfonate group), an optionally substituted aryl group or a -SiR11R12R13 group; R10 is an alkyl, aryl or acyl group; and R11, R12 and R13 are independently an optionally substituted alkoxy or alkyl group; polymers derived therefrom; a process for polymerizing a thiophene according to formula (I), optionally chemically or electrochemically; and solutions, dispersions, pastes and layers containing polymers derived therefrom.

  一种由式(I)代表的噻吩化合物： 其中 A 代表 C1-5 烯桥；R 代表 -R1-COR2 基团；-R1- 代表 -R3- 或 -R4-X-R5- 基团；R2 是氢、羟基、硫醇基、-NR6R7、-OR8 或 -SR9 基团；R3、R4 和 R5 独立地是亚烯基或芳烯基；X 是 -O-、-S- 或 =NR10；R6 和 R7 独立地是氢、任选取代的氨基或任选取代的烷基；R8 和 R9 独立地是任选取代的烷基（任选具有至少一个从醇、酰胺、醚、酯或磺酸盐基团中选出的取代基）、任选取代的芳基或 -SiR11R12R13 基团；R10 是烷基、芳基或酰基；以及 R11、R12 和 R13 独立地是任选取代的烷氧基或烷基；由此衍生的聚合物；根据式（I）的噻吩任选通过化学或电化学聚合的工艺；以及含有由此衍生的聚合物的溶液、分散体、糊剂和层。
• 3,4-ALKYLENEDIOXYTHIOPHENE COMPOUNDS AND POLYMERS THEREOF
  申请人：AGFA-GEVAERT

  公开号：EP1458784B1

  公开（公告）日：2008-01-16
• US6852830B2
  申请人：——

  公开号：US6852830B2

  公开（公告）日：2005-02-08