methyl altropyranoside | 1015171-23-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl altropyranoside
• 英文别名: methyl D-altroside；(2R,3S,4R,5S)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol
• CAS: 1015171-23-9
• 化学式: C₇H₁₄O₆
• 分子量: 194.185
• InChiKey: HOVAGTYPODGVJG-QTSLKERKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl altropyranoside 在 镍 四碘甲烷 、 氢气 、 三苯基膦 作用下， 以 吡啶 、 甲醇 为溶剂， 反应 21.0h， 生成 methyl 6-deoxy-D-altroside
  参考文献：
  名称：

  Characterization of 6-deoxy-d-altritol in the cell-wall polysaccharide of Nocardia asteroides R 399

  摘要：

  A polyol, found in the cell-wall of Nocardia asteroides R 399 as a component of a neutral polysaccharide mainly composed of D-arabinose and D-galactose, was identified by mass spectrometry, paper chromatography, thin-layer chromatography, and gas chromatography as 6-deoxy-D-altritol.

  DOI：

  10.1016/s0008-6215(00)90459-2
• 作为产物：
  描述：

  甲醇 、 a-L-阿卓吡喃糖 在 盐酸 作用下， 反应 24.0h， 生成 methyl altropyranoside
  参考文献：
  名称：

  Characterization of 6-deoxy-d-altritol in the cell-wall polysaccharide of Nocardia asteroides R 399

  摘要：

  A polyol, found in the cell-wall of Nocardia asteroides R 399 as a component of a neutral polysaccharide mainly composed of D-arabinose and D-galactose, was identified by mass spectrometry, paper chromatography, thin-layer chromatography, and gas chromatography as 6-deoxy-D-altritol.

  DOI：

  10.1016/s0008-6215(00)90459-2

文献信息

• General method for preparing altrosides from 2,3-manno-epoxides and its application to synthesis of alternative β-cyclodextrin with an altroside as the constituent of macrocyclic structure
  作者：Kahee Fujita、Kazuko Ohta、Yoshihiro Ikegami、Hideaki Shimada、Tsutomu Tahara、Yasuyoshi Nogami、Toshitaka Koga、Kazuki Saito、Terumi Nakajima

  DOI：10.1016/0040-4039(94)88515-x

  日期：1994.12

  A general and convenient method for preparing altrosides from 2,3-manno-epoxides is described and as the application, 2A(S),3A(R)-β-Cyclodextrin which has an altroside as the constituent was prepared and assigned;the altroside part has 1C4 conformation predominantly.

  描述了一种由2，3-甘露聚糖环氧化物制备皂苷的通用且方便的方法，并且作为申请，制备并指定了以皂苷为成分的2 A（S），3 A（R）-β-环糊精。皂苷部分主要具有1 C 4构象。
• TYPE IV SECRETION SYSTEM INHIBITORS
  申请人：Hadjifrangiskou Maria

  公开号：US20170233409A1

  公开（公告）日：2017-08-17

  Described are compounds, compositions, and methods for treating or preventing conditions or disorders caused by or associated with bacterial type IV secretion systems.

  描述了用于治疗或预防由细菌类型IV分泌系统引起或相关的疾病或疾病的化合物、组合物和方法。
• Alkylated hexitol nucleoside analogues and oligomers thereof
  申请人：——

  公开号：US20040033967A1

  公开（公告）日：2004-02-19

  The present invention is directed to nucleoside analogues with as substitute for the sugar part a 1,5-anhydrohexitol moiety, doexygenated and substituted with a nucleobase at the 2-position, of which the hexitorl ring is further substituted with at least one alkoxy substituent at the 3-position or at the 1-position, and to oligonucleotides wherein at least some of the nucleotides are part of the afore mentioned hexitol nucleoside analogues and exhibit sequence-specific hydridization to complementary sequences of nucleic acids, and maintaining or improving the hybridisation strength. The invention further relates to nucleoside analogues with a 1,5-anhydrohexitol moiety as the sugar part, deoxygenated and substituted with a nucleobase at the 2-position, of which the hexitol ring is substituted with a methoxy substituent at the 1-position, having at the same time either a hydroxy or an alkoxy group at the 3-position, or having a 3-deoxygenated position. The inclusion of one or more of the afore mentioned hexitol nucleoside analogues in oligonucleotides provides, inter alia, either for improved binding or for maintained binding of these oligonucleotides to a complementary strand. This invention further relates to the chemical synthesis of these oligomers which are useful diagnostics, therapeutics and as research agents.

  本发明涉及以1,5-脱水己糖基取代糖部分的核苷类似物，其在2位上以核碱基进行脱氧和取代，其中己糖环在3位或1位进一步取代至少一个烷氧基取代基，以及寡核苷酸，其中至少一些核苷酸是前述己糖核苷类似物的一部分，并对核酸的互补序列表现出序列特异性杂交，并维持或提高杂交强度。本发明还涉及以1,5-脱水己糖基为糖部分、在2位上脱氧和取代核碱基、在己糖环上以甲氧基取代基在1位取代、同时在3位具有羟基或烷氧基，或者在3位脱氧的核苷类似物。在寡核苷酸中包含前述己糖核苷类似物中的一个或多个，可提供改进的结合或维持这些寡核苷酸与互补链的结合。本发明还涉及这些寡聚体的化学合成，它们是有用的诊断、治疗和研究试剂。
• KITAZAWA, SADAYA;OKUMURA, MASAKAZU;KINOMURA, KEISUKE;SAKAKIBARA, TOSHIYUK+, CHEM. LETT.,(1990) N, C. 1733-1736
  作者：KITAZAWA, SADAYA、OKUMURA, MASAKAZU、KINOMURA, KEISUKE、SAKAKIBARA, TOSHIYUK+

  DOI：——

  日期：——
• DOARES, STEVEN H.;ALBERSHEIM, PETER;DARVILL, ALAN G., CARBOHYDR. RES., 210,(1991) C. 311-317
  作者：DOARES, STEVEN H.、ALBERSHEIM, PETER、DARVILL, ALAN G.

  DOI：——

  日期：——