2-fluoroinosine | 13276-42-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-fluoroinosine
• 英文别名: 2-fluorinosine；Inosine, 2-fluoro-；9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-fluoro-1H-purin-6-one
• CAS: 13276-42-1
• 化学式: C₁₀H₁₁FN₄O₅
• 分子量: 286.22
• InChiKey: RHLSRGWIGPHHJW-UUOKFMHZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  鸟苷 在 吡啶 、 亚硝酸特丁酯 、 氢氟酸 作用下， 反应 1.0h， 以80.4%的产率得到2-fluoroinosine
  参考文献：
  名称：

  The Synthesis of 2-Fluoropurine Nucleosides

  摘要：

  2-Aminoadenosine, obtained by silylation-amination from guanosine, is readily converted by KNO2/ HF/Pyridine in up to 80% yield into 2-fluoradenosine, which is a convenient starting material for the preparation of 9(beta-D-arabinafulanosyl)-2-fluoroadenine 5'-phosphate (Fludara). N-6,N-6-Pentamethylene-2-aminoadenosine, and guanosine afford likewise the corresponding 2-fluoropurine nucleosides in high yields.

  DOI：

  10.1080/15257779408013271

文献信息

• [EN] METHODS OF QUANTIFYING METHYLGLYOXAL-INDUCED NUCLEIC ACID ADDUCTS<br/>[FR] PROCÉDÉS DE QUANTIFICATION D'ADDUITS À L'ACIDE NUCLÉIQUE INDUITS PAR LE MÉTHYLGLYOXAL
  申请人：HOPE CITY

  公开号：WO2019152728A1

  公开（公告）日：2019-08-08

  Methods of quantifying a N 2 -(1-carboxyethyl)-2'-deoxyguanosine (CEdG) and N 2 -(1-carboxyethyl)-guanosine (CEG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG and CEG levels before and after treatment. Measurement of CEdG and CEG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.

  测量生物样本中N2-(1-羧基乙基)-2'-脱氧鸟苷（CEdG）和N2-(1-羧基乙基)-鸟苷（CEG）水平的方法，并将这些水平与已知的正常水平进行比较，可以诊断出许多代谢性疾病或相关并发症，包括糖尿病、其相关并发症和癌症。该方法还可以通过在治疗前后测量CEdG和CEG水平来确定治疗疾病的疗效。使用液相色谱电喷雾离子化串联质谱技术可实现CEdG和CEG水平的测量。
• Guanidinium functionalized oligomers and methods
  申请人：——

  公开号：US20030092046A1

  公开（公告）日：2003-05-15

  The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.

  本发明提供了寡核苷酸，它们与RNA或DNA的选定序列具有特异性杂交性，其中至少一个核苷酸基团被修饰以包括一种鸟氨酸基团。这些寡核苷酸对于诊断、治疗和调查目的非常有用。
• Aminooxy functionalized oligomers, oligomer arrays and methods of using them
  申请人：——

  公开号：US20030113769A1

  公开（公告）日：2003-06-19

  The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include an aminooxy linkage. These oligomers are useful for diagnostic, therapeutic and investigative purposes.

  本发明提供了能够与所选的RNA或DNA序列特异性杂交的寡聚物，其中寡聚物的核苷酸基团中至少一个被修饰为含有氨氧基连接。这些寡聚物可用于诊断、治疗和研究目的。
• [EN] NEW METHOD OF PREPARING 2-FLUOROPURINE DERIVATIVES
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：WO1993011144A1

  公开（公告）日：1993-06-10

  (DE) Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 2-Fluorpurin-Derivaten aus 2-Aminopurin-Derivaten, die in HF/Pyridin oder HF/Pyridin/H2O in Gegenwart eines Nitrits umgesetzt werden.(EN) The invention concerns a method for the preparation of 2-fluoropurine derivatives from 2-aminopurine derivatives which are transformed into HF/pyridine or HF/pyridine/H2O in the presence of a nitrite.(FR) L'invention concerne un procédé de fabrication de dérivés de la 2-fluoropurine à partir de dérivés de la 2-aminopurine, par transformation en HF/pyridine ou HF/pyridine/H2O, en présence d'un nitrite.

  (DE) 本发明涉及一种制备2-Fluoropurin-Derivates的方法，从2-Aminopurin-Derivates制备，后者在HF/Pyridin或HF/Pyridin/H2O条件下，当受硝酸盐转化时。 (EN) The invention concerns a method for the preparation of 2-fluoropurine derivatives from 2-aminopurine derivatives which are transformed into HF/pyridine or HF/pyridine/H2O in the presence of a nitrite. (
• NEUES VERFAHREN ZUR HERSTELLUNG VON 2-FLUORPURIN-DERIVATEN
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：EP0614462A1

  公开（公告）日：1994-09-14