1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxylic acid | 1431373-77-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxylic acid
• CAS: 1431373-77-1
• 化学式: C₂₅H₃₁F₃N₂O₅
• 分子量: 496.5
• InChiKey: WRAJSSUVHACADP-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  35
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  91.3
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• PHARMACEUTICAL COMPOSITIONS OF SILODOSIN
  申请人：Roy Sunilendu Bhushan

  公开号：US20140243383A1

  公开（公告）日：2014-08-28

  The present invention discloses a stable pharmaceutical composition comprising: (a) plurality of granules comprising silodosin or salts thereof and one or more pharmaceutical excipients; and (b) an extragranular portion comprising one or more lubricants and optionally one or more surfactants, wherein the granules are free of partially pregelatinized starch.
• [EN] PHARMACEUTICAL COMPOSITIONS OF SILODOSIN<br/>[FR] COMPOSITIONS PHARMACEUTIQUES DE SILODOSINE
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2013061338A1

  公开（公告）日：2013-05-02

  The present invention discloses a stable pharmaceutical composition comprising - (a) plurality of granules comprising silodosin or salts thereof and one or more pharmaceutical excipients; and (b) an extragranular portion comprising one or more lubricants and optionally one or more surfactants, wherein the granules are free of partially pregelatinized starch.