2-[2-(3-pyridyl)-1H-indol-3-yl]-1-ethanamine | 501360-13-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[2-(3-pyridyl)-1H-indol-3-yl]-1-ethanamine
• 英文别名: 2-(2-pyridin-3-yl-1H-indol-3-yl)ethanamine
• CAS: 501360-13-0
• 化学式: C₁₅H₁₅N₃
• mdl: MFCD11558815
• 分子量: 237.304
• InChiKey: SZLBNNSKJUHQMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-甲基-2-氧基戊酸 、 2-[2-(3-pyridyl)-1H-indol-3-yl]-1-ethanamine 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 3-methyl-2-oxo-N-[2-(2-pyridin-3-yl-1H-indol-3-yl)ethyl]pentanamide
  参考文献：
  名称：

  Studies on the novel anti-staphyloccal compound nematophin

  摘要：

  A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00331-0
• 作为产物：
  描述：

  2-(2-(1H-吲哚-3-基)乙基)异吲哚啉-1,3-二酮 在 四(三苯基膦)钯 、 sodium carbonate 、 pyridinium hydrobromide perbromide 、 二甲胺 、 lithium chloride 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 甲苯 为溶剂， 生成 2-[2-(3-pyridyl)-1H-indol-3-yl]-1-ethanamine
  参考文献：
  名称：

  Studies on the novel anti-staphyloccal compound nematophin

  摘要：

  A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00331-0

文献信息

• [EN] RENIN INHIBITORS<br/>[FR] INHIBITEURS DE LA RÉNINE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2010111634A2

  公开（公告）日：2010-09-30

  The invention relates to compounds having the formula: ##STR## wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, intermediates which can be used to make the compounds, and pharmaceutical compositions, kits and articles of manufacture which contain the compounds.
• Studies on the novel anti-staphyloccal compound nematophin
  作者：Gordon Kennedy、Monica Viziano、John Alexander Winders、Palmina Cavallini、Monica Gevi、Fabrizio Micheli、Pamela Rodegher、Pierfausto Seneci、Aurelia Zumerle

  DOI：10.1016/s0960-894x(00)00331-0

  日期：2000.8

  A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active. (C) 2000 Elsevier Science Ltd. All rights reserved.