2-[2-(2-pyridin-3-yl-1H-indol-3-yl)ethyl]isoindole-1,3-dione | 294210-83-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[2-(2-pyridin-3-yl-1H-indol-3-yl)ethyl]isoindole-1,3-dione
• CAS: 294210-83-6
• 化学式: C₂₃H₁₇N₃O₂
• 分子量: 367.407
• InChiKey: QORGPFLYZMYOCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[2-(2-pyridin-3-yl-1H-indol-3-yl)ethyl]isoindole-1,3-dione 在 二甲胺 作用下， 以 甲醇 为溶剂， 生成 2-[2-(3-pyridyl)-1H-indol-3-yl]-1-ethanamine
  参考文献：
  名称：

  Studies on the novel anti-staphyloccal compound nematophin

  摘要：

  A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00331-0
• 作为产物：
  描述：

  2-(2-(1H-吲哚-3-基)乙基)异吲哚啉-1,3-二酮 在 四(三苯基膦)钯 、 sodium carbonate 、 pyridinium hydrobromide perbromide 、 lithium chloride 作用下， 以 四氢呋喃 、 乙醇 、 甲苯 为溶剂， 生成 2-[2-(2-pyridin-3-yl-1H-indol-3-yl)ethyl]isoindole-1,3-dione
  参考文献：
  名称：

  Studies on the novel anti-staphyloccal compound nematophin

  摘要：

  A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00331-0