N-formyl-2,3-dimethoxy-5,6,7,8-tetrahydrodiben[c,e]azocine | 65762-80-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-formyl-2,3-dimethoxy-5,6,7,8-tetrahydrodiben[c,e]azocine
• 英文别名: 6-formyl-2,3-dimethoxy-5,6,7,8-tetrahydro-dibenzo[c,e]azocine；4,5-Dimethoxy-9-azatricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene-9-carbaldehyde
• CAS: 65762-80-3
• 化学式: C₁₈H₁₉NO₃
• 分子量: 297.354
• InChiKey: HXODZEJUZYAFAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-formyl-2,3-dimethoxy-5,6,7,8-tetrahydrodiben[c,e]azocine 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 以94%的产率得到buflavine
  参考文献：
  名称：

  Synthesis of Amaryllidaceae alkaloids, siculine, oxocrinine, epicrinine, and buflavine

  摘要：

  Three crinane type of alkaloids isolated from Amaryllidaceae family were synthesized by taking advantage of the PIFA-mediated intramolecular p-p' diphenol coupling reaction of norbelladine derivatives. Furthermore, buflavine was also prepared by using the p-p' diphenol coupling followed by dienone-phenol rearrangement as a key step. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.03.087
• 作为产物：
  描述：

  对羟基苯乙胺 在 palladium diacetate 吡啶 、 甲酸 、 甲烷磺酸 、 2,2,2-三氟乙醇 、 三乙胺 、 三苯基膦 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 114.5h， 生成 N-formyl-2,3-dimethoxy-5,6,7,8-tetrahydrodiben[c,e]azocine
  参考文献：
  名称：

  Synthesis of Amaryllidaceae alkaloids, siculine, oxocrinine, epicrinine, and buflavine

  摘要：

  Three crinane type of alkaloids isolated from Amaryllidaceae family were synthesized by taking advantage of the PIFA-mediated intramolecular p-p' diphenol coupling reaction of norbelladine derivatives. Furthermore, buflavine was also prepared by using the p-p' diphenol coupling followed by dienone-phenol rearrangement as a key step. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.03.087

文献信息

• Synthesis of Amaryllidaceae alkaloids, siculine, oxocrinine, epicrinine, and buflavine
  作者：Sumiaki Kodama、Hirofumi Takita、Tetsuya Kajimoto、Kiyoharu Nishide、Manabu Node

  DOI：10.1016/j.tet.2004.03.087

  日期：2004.5

  Three crinane type of alkaloids isolated from Amaryllidaceae family were synthesized by taking advantage of the PIFA-mediated intramolecular p-p' diphenol coupling reaction of norbelladine derivatives. Furthermore, buflavine was also prepared by using the p-p' diphenol coupling followed by dienone-phenol rearrangement as a key step. (C) 2004 Elsevier Ltd. All rights reserved.