(E)-2-hexyldec-2-enal | 64935-39-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-2-hexyldec-2-enal
• 英文别名: 2-Hexyl-2-decenal
• CAS: 64935-39-3
• 化学式: C₁₆H₃₀O
• 分子量: 238.414
• InChiKey: RSBRHLFCWKXUSQ-JQIJEIRASA-N

物化性质

• 沸点：
  126-127 °C(Press: 3.5 Torr)
• 密度：
  0.841±0.06 g/cm3(Predicted)
• 保留指数：
  1769

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-2-hexyldec-2-enal 在 Rase Bengal bis(triethylammonium) salt 、 potassium tert-butylate 、 氧气 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 6.25h， 生成 3-heptyl-4-hexyl-3,6-dihydro-1,2-dioxin
  参考文献：
  名称：

  Design of endoperoxides with anti-Candida activity

  摘要：

  Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides I are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.021
• 作为产物：
  描述：

  正辛醛 在 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 (E)-2-hexyldec-2-enal
  参考文献：
  名称：

  巨大芽孢杆菌将脂肪族醛类微生物转化为2,3-二烷基丙烯醛。

  摘要：

  研究了从草莓叶片表面分离出的巨大芽孢杆菌对一系列脂肪醛（C（8）-C（12））的生物转化。通过液/液萃取分离产物，并通过气相色谱法（GC）和质谱法（MS）进行分析。除了脂族醇和其余的醛以外，主要的转化产物还包括相应的酸以及2,3-二烷基丙烯醛，脱水的羟醛加成产物，它们是首次作为生物转化产物被检测到的。为了验证结构，通过碱催化的醛醇缩合反应从适当的醛化学合成了2,3-二烷基丙烯醛，并通过（1）H和（13）C NMR光谱进行了表征。

  DOI：

  10.1021/jf049148i

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• A green method for the self-aldol condensation of aldehydes using lysine
  作者：Yutaka Watanabe、Kazue Sawada、Minoru Hayashi

  DOI：10.1039/b918349c

  日期：——

  A self-condensation of aldehydes has been conveniently accomplished by the catalytic action of lysine in water or a solvent-free system under specific emulsion conditions to give α-branched α,β-unsaturated aldehydes in good yields.

  在特定乳液条件下，通过赖氨酸的催化作用，在水或无溶剂体系中，方便地实现了醛的自缩合，获得了良好产率的α-支链α,β-不饱和醛。
• ALKYL H-PHOSPHONATES OF N,N'-DIALKYLIMIDAZOLIUMS AND OF QUATERNARY AMMONIUMS AND USES THEREOF
  申请人：Nguyen Hoang-Phuong

  公开号：US20100121075A1

  公开（公告）日：2010-05-13

  The application relates to the use of a salt associating an ammonium cation with an alkyl H-phosphonate anion of the following formula (I) in which R is a hydrocarbon radical, the pointed bond can be present or not, the radical R 3 being then present or absent, as an ionic liquid. The ammonium cation is preferably an imidazolium cation. This ionic liquid is particularly useful in the field of green chemistry as a substitute for organic solvents. The application also relates to a method for preparing such a salt by the direct dealkylation of the corresponding dialkylphosphite by the appropriate nitrated base, in one step and without any solvent. The application also relates to a method for preparing mixed methylated phosphites.

  该申请涉及使用盐将氨基阳离子与以下式(I)中的烷基H-膦酸盐结合，其中R是一个碳氢基团，指示的键可以存在也可以不存在，基团R3则存在或不存在，作为离子液体。氨基阳离子最好是咪唑阳离子。这种离子液体在绿色化学领域中特别有用，可作为有机溶剂的替代品。该申请还涉及通过适当的硝基碱直接脱烷基化相应的二烷基膦酸酯来制备这种盐的方法，一步完成且无需任何溶剂。该申请还涉及制备混合甲基化膦酸酯的方法。
• Silica gel-mediated self-aldol reactions of highly volatile aldehydes under organic solvent-free conditions without reflux condenser
  作者：Kiyoshi Tanemura

  DOI：10.1016/j.tetlet.2019.06.030

  日期：2019.7

  Silica gel-mediated self-aldol reactions were catalyzed by piperidine to give the corresponding α,β-conjugated aldehydes in good yields. The aldol reactions of 4-nitro-, 4-trifluoromethyl-, and 4-chlorobenzaldehydes with acetone afforded the corresponding aldol products. Highly volatile aldehydes and acetone could be employed even without a reflux condenser for these reactions. Silica gel could be recycled

  哌啶催化硅胶介导的自醛醇缩合反应，以高收率得到相应的α，β-共轭醛。4-硝基-，4-三氟甲基-和4-氯苯甲醛与丙酮的醛醇缩合反应得到相应的醛醇产物。即使没有回流冷凝器，也可以使用高挥发性的醛和丙酮进行这些反应。硅胶可以循环使用五次，而产物的收率却没有显着降低。
• Palladium-catalyzed α-arylation of aldehydes with aryl bromides
  作者：Yoshito Terao、Yuichi Fukuoka、Tetsuya Satoh、Masahiro Miura、Masakatsu Nomura

  DOI：10.1016/s0040-4039(01)02077-9

  日期：2002.1

  Aliphatic linear and α-branched aldehydes efficiently undergo arylation at the α-position upon treatment with aryl bromides using an appropriate palladium catalyst system that is capable of overcoming aldol condensation of the substrates.

  使用合适的钯催化剂体系，通过芳基溴化物处理后，脂族线性和α-支化醛可在α-位有效地发生芳基化反应，该钯催化剂体系能够克服底物的醇醛缩合反应。