L-aspartic acid, compound with L-arginine (1:1) | 7675-83-4

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 精氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-aspartic acid, compound with L-arginine (1:1)
• 英文别名: arginine aspartate；2-Aminobutanedioic acid;2-amino-5-(diaminomethylideneamino)pentanoic acid
• CAS: 7675-83-4
• 化学式: C₄H₇NO₄*C₆H₁₄N₄O₂
• 分子量: 307.307
• InChiKey: SUUWYOYAXFUOLX-UHFFFAOYSA-N

物化性质

• 熔点：
  220-221 °C
• 溶解度：
  极易溶于水，几乎不溶于乙醇和二氯甲烷。
• LogP：
  -1.287 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.68
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  228
• 氢给体数：
  7
• 氢受体数：
  9

安全信息

• 海关编码：
  2925290090
• WGK Germany：
  3
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  -20°C

制备方法与用途

临床应用

L-精氨酸和L-天门冬氨酸可用作化妆品氨基酸营养剂、氨基酸营养食品添加物等。在临床上，它们常用于减轻疲劳、神经衰弱、失眠以及记忆力减退等症状，并且没有毒性。

用途

用作化妆品氨基酸营养剂、氨基酸营养食品添加物等

文献信息

• Topical and oral formulations of cardiac glycosides for treating skin diseases
  申请人：Streeper Robert

  公开号：US20060205679A1

  公开（公告）日：2006-09-14

  The present invention provides method, preparation and use of a variety of pharmaceutical compositions containing at least one digitalis glycoside such as oleandrin, odoroside-A, neriifolin, proscillaridin-A, methyl-proscillaridin-A, digitoxin, digoxin alone or at least one digitalis glycoside complexed with cyclodextrins. In another aspect, the present invention provides an effective method to treat diseases in mammals. In yet another aspect, the present invention provides an effective method for treating skin diseases in a human or non-human animal.

  本发明提供了一种方法、制备和使用多种含有至少一种毛地黄苷类药物成分的药物组合物，例如奥利安定、奥多罗苷A、内里福林、普罗斯西拉里丁A、甲基普罗斯西拉里丁A、地高辛、地高辛或至少一种毛地黄苷类与环糊精络合的药物。另一方面，本发明提供了一种有效的方法来治疗哺乳动物的疾病。另一方面，本发明提供了一种有效的方法来治疗人类或非人类动物的皮肤疾病。
• [EN] COMBINING BETA-DIPEPTIDES AND AMINO ACIDS FOR OPTIMAL NUTRITIONAL SUPPLEMENTATION<br/>[FR] COMBINAISON DE BÊTA-DIPEPTIDES ET D'ACIDES AMINÉS POUR UN COMPLÉMENT NUTRITIONNEL OPTIMAL
  申请人：CYSAL GMBH

  公开号：WO2020025656A1

  公开（公告）日：2020-02-06

  The invention relates to anutritional supplement comprising a combination of one or more β-aspartyl-containing dipeptides,oroligomers thereof, or salts thereof, wherein each of the β-dipeptides comprises β-L-aspartyl as a first amino acid residue and an amino acid selected from arginine, lysine, ornithine, and citrulline as the second amino acid residue, and the respective second amino acid(s) or salts thereof. The invention further relates to the use of the combination for nutritional supplementation and to the combination for use in amino acid therapy.

  这项发明涉及一种营养补充剂，包括一种或多种β-天冬氨酰基二肽的组合，或其寡聚体，或其盐，其中每个β-二肽包括β-L-天冬氨酰作为第一个氨基酸残基，以及从精氨酸、赖氨酸、鸟氨酸和瓜氨酸中选择的氨基酸作为第二个氨基酸残基，以及相应的第二个氨基酸或其盐。该发明还涉及利用该组合进行营养补充以及用于氨基酸疗法的该组合。
• Esters of capsaicin for treating pain
  申请人：Singh Chandra Ulagaraj

  公开号：US20080020996A1

  公开（公告）日：2008-01-24

  The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The pharmaceutical compositions of the present invention contain a compound of following formula (Ia): R—CO-CAP   (Ia) wherein CAP refers to collectively the capsaicins represented in FIG. 1 and a compound of formula (Ib): MCO-O—R   (Ib) wherein MCO refers to myristoleic acid. In formulae Ia and Ib, R is selected from alkyl groups of up to about 18 carbon atoms and aryl groups of up to about 18 carbon atoms and alkylene group of up to about 18 carbon atoms and an arylene group of up to about 18 carbon atoms. The alkyl, aryl and alkylene groups may be substituted or un-substituted, branched or straight chains. In addition, R may contain heteroatoms and may be straight chained or branched. The pharmaceutical compositions containing compounds of formulae Ia and Ib are useful for pain management in mammals in vivo and have been contemplated to be used in the treatment of various pains in humans.

  本发明涉及辣椒素酯衍生物和肉豆蔻油酸酯衍生物的配方。这些衍生物能够在酶解或化学水解后恢复为活性母化合物。这些衍生物具有更高的亲脂性、脂溶性，对皮肤的刺激性较小，因此更容易被纳入某些药物配方中，包括膏剂和药膏配方。本发明的药物组合物含有下式（Ia）的化合物：R—CO-CAP（Ia），其中CAP指的是在图1中表示的辣椒素，和下式（Ib）的化合物：MCO-O—R（Ib），其中MCO指的是肉豆蔻油酸。在式Ia和Ib中，R选自碳原子数最多约为18的烷基基团和碳原子数最多约为18的芳基基团以及碳原子数最多约为18的烷基基团和碳原子数最多约为18的芳基基团。烷基、芳基和烷基基团可以是取代或未取代的，支链或直链。此外，R可能含有杂原子，可能是直链或支链的。含有式Ia和Ib的药物组合物对于体内哺乳动物的疼痛管理是有用的，并已考虑用于治疗人类的各种疼痛。
• [EN] BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING<br/>[FR] COMPOSITIONS BINAIRES UTILISÉES COMME PERTURBATEURS DE DÉTECTION DE SUBSTANCES ODORANTES DÉPENDANT DES RÉCEPTEURS ORCO
  申请人：UNIV VANDERBILT

  公开号：WO2016154471A1

  公开（公告）日：2016-09-29

  In one aspect, the invention relates to binary compositions that disrupt ORco- mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in organisms that express ORco receptors such as airborne insects, e.g., mosquitos, and ticks. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在某个方面，本发明涉及破坏ORco介导的气味感应的二元组合物。具体地，提供了可以抑制表达ORco受体的生物体（例如空气传播昆虫，如蚊子和蜱）的感觉（例如宿主定位）功能的化合物和组合物。还提供了使用这些药剂的方法和包含这些药剂的文章。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• [EN] STABILIZED COMPOSITIONS CONTAINING BENZIMIDAZOLE-TYPE COMPOUNDS<br/>[FR] COMPOSITIONS STABILISEES CONTENANT DES COMPOSES DU TYPE BENZIMIDAZOLE
  申请人：EISAI CO., LTD.

  公开号：WO1999053918A1

  公开（公告）日：1999-10-28

  (EN) Chemically stabilized preparations of benzimidazole-type compounds. These compositions comprise the benzimidazole-type compounds or alkali metal salts thereof together with at least one substance selected from among sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, aminoalkyl methacrylate copolymer E, arginine aspartate, hydroxypropyl cellulose and crospovidone.(FR) On décrit des compositions chimiquement stabilisées de composés du type benzimidazole. Ces compositions contiennent les composés du type benzimidazole ou les sels de métal alcalin de ces derniers ainsi qu'une substance sélectionnée entre le carbonate de sodium, le carbonate de potassium, l'hydroxyde de sodium, l'hydroxyde de potassium, le copolymère E d'aminoalkylméthacrylate, l'aspartate d'arginine, l'hydroxypropylcellulose et le crospovidone.

  化学稳定的苯并咪唑类化合物制剂。这些组合物包括苯并咪唑类化合物或其碱金属盐，以及至少一种物质，选择自碳酸钠、碳酸钾、氢氧化钠、氢氧化钾、氨基烷基甲基丙烯酸酯共聚物E、天冬氨酸精盐、羟丙基纤维素和交联聚乙烯吡咯烷酮。