N,N-diethyl-2-(quinolin-8-yloxy)acetamide | 3135-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,N-diethyl-2-(quinolin-8-yloxy)acetamide
• 英文别名: N,N-diethyl-2-quinolin-8-yloxyacetamide
• CAS: 3135-44-2
• 化学式: C₁₅H₁₈N₂O₂
• 分子量: 258.32
• InChiKey: LJMLEUXJUCCEOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-diethyl-2-(quinolin-8-yloxy)acetamide 在 劳森试剂 作用下， 以 甲苯 为溶剂， 以35%的产率得到N,N-diethyl-2-(quinolin-8-yloxy)ethanethioamide
  参考文献：
  名称：

  Fluorogenic Hg²⁺-Selective Chemodosimeter Derived from 8-Hydroxyquinoline

  摘要：

  A new thioamide derivative of 8-hydroxyquinoline-benzothiazole was prepared, and its fluorogenic chemodosimetric behaviors toward transitionmetal ions were investigated. The thioamide derivative showed highly Hg2+-selective fluorescence enhancing properties (167-fold) in 30% aqueous acetonitrile solution. The selective and sensitive signaling behaviors were found to originate from the Hg2+ ion induced transformation of the very weak fluorescent thioamide derivative into a highly fluorescent amide analogue.

  DOI：

  10.1021/ol060788b
• 作为产物：
  描述：

  8-羟基喹啉 、 N,N-二乙基-2-氯乙酰胺 在 potassium carbonate 、 potassium iodide 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到N,N-diethyl-2-(quinolin-8-yloxy)acetamide
  参考文献：
  名称：

  Fluorogenic Hg²⁺-Selective Chemodosimeter Derived from 8-Hydroxyquinoline

  摘要：

  A new thioamide derivative of 8-hydroxyquinoline-benzothiazole was prepared, and its fluorogenic chemodosimetric behaviors toward transitionmetal ions were investigated. The thioamide derivative showed highly Hg2+-selective fluorescence enhancing properties (167-fold) in 30% aqueous acetonitrile solution. The selective and sensitive signaling behaviors were found to originate from the Hg2+ ion induced transformation of the very weak fluorescent thioamide derivative into a highly fluorescent amide analogue.

  DOI：

  10.1021/ol060788b