10-Oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11,13,15(19),16-heptaen-18-one | 1187578-27-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-Oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11,13,15(19),16-heptaen-18-one
• 英文别名: 10-oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11,13,15(19),16-heptaen-18-one
• CAS: 1187578-27-3
• 化学式: C₁₇H₁₃NO₂
• 分子量: 263.296
• InChiKey: VOEIZRGZVDRDLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  8-羟基喹啉 、 1,2-二(溴甲基)苯 在 十六烷基三甲基溴化铵 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.0h， 以90%的产率得到10-Oxa-1-azatetracyclo[9.7.1.03,8.015,19]nonadeca-3,5,7,11,13,15(19),16-heptaen-18-one
  参考文献：
  名称：

  Synthesis of polycyclic fused 2-quinolones in aqueous micellar system

  摘要：

  A high yielding green protocol has been developed for the synthesis of tri-, tetra-, and pentacyclic fused 2-quinolones in micellar medium. The method is more effective compared to phase-transfer catalytic (PTC) method in terms of the yield of the product as well as the reaction time. It is operationally simple as well as environmentally benign. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.030

文献信息

• Synthesis of novel benzoxazocino quinoliniums and quinolones under PTC conditions and their application in Suzuki cross coupling reaction for the construction of polynuclear heteroaromatics
  作者：Krishnendu B. Sahu、Abhijit Hazra、Priyankar Paira、Pritam Saha、Subhendu Naskar、Rupankar Paira、Sukdeb Banerjee、Niranjan P. Sahu、Nirup B. Mondal、Peter Luger、Manuela Weber

  DOI：10.1016/j.tet.2009.06.061

  日期：2009.8

  A general and highly efficient synthetic protocol under phase transfer catalytic condition has been established for the synthesis of fused tetracyclic oxazocinoquinolone analogues which served as the precursors for novel biaryl quinolones using microwave assisted Suzuki cross coupling reaction. (C) 2009 Elsevier Ltd. All rights reserved.
• Synthesis of polycyclic fused 2-quinolones in aqueous micellar system
  作者：Subhendu Naskar、Pritam Saha、Rupankar Paira、Abhijit Hazra、Priyankar Paira、Shyamal Mondal、Arindam Maity、Krishnendu B. Sahu、Sukdeb Banerjee、Nirup B. Mondal

  DOI：10.1016/j.tetlet.2010.01.030

  日期：2010.3

  A high yielding green protocol has been developed for the synthesis of tri-, tetra-, and pentacyclic fused 2-quinolones in micellar medium. The method is more effective compared to phase-transfer catalytic (PTC) method in terms of the yield of the product as well as the reaction time. It is operationally simple as well as environmentally benign. (C) 2010 Elsevier Ltd. All rights reserved.