N-(4-(4-chloroquinolin-2-yl)benzyl)-3-morpholinopropan-1-amine | 1246760-59-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(4-(4-chloroquinolin-2-yl)benzyl)-3-morpholinopropan-1-amine
• 英文别名: N-[[4-(4-chloroquinolin-2-yl)phenyl]methyl]-3-morpholin-4-ylpropan-1-amine
• CAS: 1246760-59-7
• 化学式: C₂₃H₂₆ClN₃O
• 分子量: 395.932
• InChiKey: ICDJQQMVCTVASB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  37.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3-氨丙基)吗啉 、 N-(4-(4-chloroquinolin-2-yl)benzyl)-3-morpholinopropan-1-amine 在 四氯化锡 作用下， 反应 4.0h， 生成 N-(3-morpholinopropyl)-2-(4-((3-morpholinopropylamino)methyl)phenyl)-quinolin-4-amine
  参考文献：
  名称：

  Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities

  摘要：

  A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.043
• 作为产物：
  描述：

  N-(3-氨丙基)吗啉 、 4-chloro-2-(4-(chloromethyl)phenyl)quinoline 以 二氯甲烷 为溶剂， 以95%的产率得到N-(4-(4-chloroquinolin-2-yl)benzyl)-3-morpholinopropan-1-amine
  参考文献：
  名称：

  Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities

  摘要：

  A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.043

文献信息

• Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities
  作者：Zeng-Yun An、Yi-Yong Yan、Dan Peng、Tian-Miao Ou、Jia-Heng Tan、Shi-Liang Huang、Lin-Kun An、Lian-Quan Gu、Zhi-Shu Huang

  DOI：10.1016/j.ejmech.2010.05.043

  日期：2010.9

  A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay. (C) 2010 Elsevier Masson SAS. All rights reserved.