phosphoric acid mono-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester | 46228-53-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: phosphoric acid mono-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester
• 英文别名: Phosphorsaeure-mono-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylester)；1,3-Dioxolane-4-methanol, 2,2-dimethyl-, dihydrogen phosphate, (4R)-；[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl dihydrogen phosphate
• CAS: 46228-53-9
• 化学式: C₆H₁₃O₆P
• 分子量: 212.139
• InChiKey: JUPNVAYKUHWAKQ-RXMQYKEDSA-N

物化性质

• 沸点：
  348.0±40.0 °C(Predicted)
• 密度：
  1.361±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  phosphoric acid mono-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester 在 2-苄基丙烷-1,3-二醇 、 N,N'-二环己基碳二亚胺 作用下， 生成 甘油磷酸酯
  参考文献：
  名称：

  Plackett,P., Australian Journal of Chemistry, 1964, vol. 17, p. 101 - 108

  摘要：

  DOI：
• 作为产物：
  描述：

  (S)-(+)-1,2-异亚丙基甘油 在 喹啉 、 三氯氧磷 作用下， 生成 phosphoric acid mono-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester
  参考文献：
  名称：

  Baer, Biochemical Preparations, 1952, vol. 2, p. 31,34

  摘要：

  DOI：

文献信息

• Analogs of lysophosphatidic acid and methods of making and using thereof
  申请人：Prestwich D. Glenn

  公开号：US20070123492A1

  公开（公告）日：2007-05-31

  Described herein are analogs of lysophosphatidic acid. Also described herein are methods of making and using analogs of lysophosphatidic acid.

  本文描述了溶血磷脂酸的类似物。本文还描述了制备和使用溶血磷脂酸类似物的方法。
• Baer; Fischer, Journal of Biological Chemistry, 1939, vol. 128, p. 482
  作者：Baer、Fischer

  DOI：——

  日期：——
• Baddiley et al., Journal of the Chemical Society, 1958, p. 3107,3109
  作者：Baddiley et al.

  DOI：——

  日期：——
• Kinetic Chiral Resolutions of 1,2-Diols and Desymmetrization of Glycerol Catalyzed by Glycerol Kinase
  作者：H. Keith Chenault、Laura F. Chafin、Sebastian Liehr

  DOI：10.1021/jo980122y

  日期：1998.6.1

  Enantioselective phosphorylation catalyzed by glycerol kinase (EC 2.7.1.30) facilitated the kinetic chiral resolution of 3-chloro-1,2-propanediol, 3-fluoro-1,2-propanediol, 3-butene-1,2-diol, and 1,2,4-butanetriol. Both enantiomers of each compound were isolated in free diol or triol form, in excellent enantiomeric purity (91 to >99.5% ee) and in moderate to good yield (60-94% of theoretical). The enantioselectivities of glycerol kinase from different sources were compared, using 1,2,4-butanetriol as the substrate. The effect of elevated temperatures on enzymatic activity, stability, and enantioselectivity were studied, and procedures for the isolation of diol and triol products were optimized. Glycerol kinase-catalyzed phosphorylation facilitated the three-step chemoenzymatic conversion of glycerol to (S)-1,2-O-isopropylideneglycerol in 83% yield and >99.5% ee).
• ACYCLOVIR DERIVATIVES FOR TOPICAL USE
  申请人：HOSTETLER, Karl Y.

  公开号：EP0746319A1

  公开（公告）日：1996-12-11