2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononane-1,1-diol | 191528-99-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononane-1,1-diol
• CAS: 191528-99-1
• 化学式: C₉H₃F₁₇O₂
• 分子量: 466.094
• InChiKey: OEUDULXFLZPWCL-UHFFFAOYSA-N

物化性质

• 沸点：
  209.9±40.0 °C(Predicted)
• 密度：
  1.755±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononane-1,1-diol 在 phosphorus pentoxide 作用下， 生成 perfluorononanal
  参考文献：
  名称：

  SnX 2 / Al促进全（聚）氟代烷基卤化物与N，N-二甲基甲酰胺的甲酰化

  摘要：

  在催化量的亚锡盐（20摩尔％）和铝粉的存在下，全（聚）氟代烷基碘或溴化物在温和的条件下与DMF平稳反应，以良好至极好的收率得到相应的全（聚）氟代烷基醛。得到含锡的中间体。提出了一种可能的机制。

  DOI：

  10.1016/0022-1139(93)02946-c
• 作为产物：
  描述：

  1H,1H-全氟-1-壬醇 在 三氟甲磺酸 、 2-碘酰基苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononane-1,1-diol
  参考文献：
  名称：

  2-碘氧苯甲酸三氟甲磺酸盐：最强大的高价碘（v）氧化剂†

  摘要：

  通过IBX与三氟甲磺酸的反应制备2-碘氧基苯甲酸（IBX）的二三氟甲磺酸酯衍生物，并通过单晶X射线晶体学表征。IBX-二甲苯磺酸盐是一系列结构相似的IBX衍生物中最强大的氧化剂，其易于氧化碳氢化合物和抗氧化多氟醇的能力得到了最好的说明。

  DOI：

  10.1039/c9cc04203b

文献信息

• Defluorinative [4 + 1] annulation of perfluoroalkyl <i>N</i>-mesylhydrazones with primary amines provides 5-fluoroalkyl 1,2,3-triazoles
  作者：Yongquan Ning、Hongwei Wang、Paramasivam Sivaguru、Shuang Li、Giuseppe Zanoni、Steven P. Nolan、Xihe Bi

  DOI：10.1039/d1gc02749b

  日期：——

  blocks. However, only a few synthetic routes to these compounds are currently available. Herein, we report on a novel method to access 5-fluoroalkyl 1,2,3-triazoles from easily prepared bench-stable perfluoroalkyl N-mesylhydrazone (PFHZ-Ms), a reagent that can transform amines to 5 fluoroalkyl 1,2,3-triazoles via defluorinative [4 + 1] annulation. The simple reaction protocol can be applied to a variety

  氟烷基 1,2,3-三唑作为药物化学构建块具有巨大的潜力。然而，目前只有少数这些化合物的合成路线可用。在此，我们报告了一种从易于制备的实验室稳定全氟烷基N-甲磺酰腙 (PFHZ-Ms) 中获取 5-氟烷基 1,2,3-三唑的新方法，PFHZ-Ms 是一种可将胺转化为 5-氟烷基 1,2,3 的试剂-三唑类通过脱氟 [4 + 1] 环化。简单的反应方案可应用于包含一系列官能团的各种胺，以良好到极好的收率提供 1,2,3-三唑。这种方法的实用性在生物活性分子的后期修饰中得到了证明。
• POLYCARBONATE-BASE POLYMER, PRODUCTION PROCESS, RESIN COATING FLUID PREPARED THEREFROM, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR PREPARED THEREFROM
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0837085A1

  公开（公告）日：1998-04-22

  A polymer comprising mainly repeating units (1) and/or repeating units (2), containing optionally terminal groups (3) and/or repeating units (4), and having a reduced viscosity [ηsp/c] of 0.2 to 10.0 dl/g as measured in a 0.5 g/dl solution thereof in methylene chloride at 20°C; a resin coating fluid containing the polymer, a charge-transfer substance and a solvent; and an electrophotographic photoreceptor containing the polymer as a binder resin in a photosensitive layer, wherein Rf1 represents a group that is composed of at least carbon atoms and fluorine atoms and bonded directly to the two oxygen atoms of the carbonate linkage in the general formula (1) without any intervening arylene group; and Rf2 represents a group that is composed of at least carbon atoms and fluorine atoms and bonded directly to one of the oxygen atoms of the carbonate linkage in the general formula (3) without any intervening arylene group.

  一种主要由重复单元（1）和/或重复单元（2）组成的聚合物，含有任选的末端基团（3）和/或重复单元（4），在 0.其中 Rf1 代表至少由碳原子和氟原子组成并直接与通式（1）中碳酸酯连接的两个氧原子键合的基团，而没有任何芳基介入；Rf2 代表一个至少由碳原子和氟原子组成的基团，直接与通式（3）中碳酸酯链节的一个氧原子键合，中间不含任何芳烯基。
• Organofluorine compounds and fluorinating agents Part 17: Sonochemical-forced preparation of perfluoroalkanals and their use for non-conventional acetalations of carbohydrates
  作者：Alexey O. Miller、Dietmar Peters、Cornelia Zur、Michael Frank、Ralf Miethchen

  DOI：10.1016/s0022-1139(96)03551-8

  日期：1997.4

  The homologous 1-iodo-perfluoroalkanes 1a-1c and alpha,omega-dibromo-perfluoroalkanes 4a, 4b were carbonylated with DMF in the presence of Al/SnCl2 or Al/PbBr2 under sonication in a short reaction time. The hydrated aldehydes 2a-2c and 5a, 5b respectively were obtained in good yields allowing dehydration to 3a-3c and 6a, 6b. Some of the fluorinated aldehydes were selected as substrates in a Wittig-Homer olefination assisted by ultrasound and in non-conventional acetalations of methyl alpha-L-rhamnopyranoside (9). Thus, (E)-1-perfluorooctyl-2-phenylsulphonyl-ethene (8) was prepared from 3c and the phosphonate 7 by Wittig-Horner synthesis. Acetalations of 9 were carried out with the aldehydes (3a, 3b, 6a), hydrated aldehydes (2a, 2b), and the aldehyde hemiacetal 12 respectively, in the presence of dicyclohexylcarbodiimide (DCC). In all cases, a selective epimerization was observed at the C-atom 3 of the monosaccharide, i.e. polyfluoroalkylidenated 6-deoxy-alpha-L-altropyranosides 10, 11, 13, and 14 were obtained. (C) 1997 Elsevier Science S.A. All rights reserved.
• 2-Iodoxybenzoic acid ditriflate: the most powerful hypervalent iodine(<scp>v</scp>) oxidant
  作者：Mekhman S. Yusubov、Natalia S. Soldatova、Pavel S. Postnikov、Rashid R. Valiev、Akira Yoshimura、Thomas Wirth、Victor N. Nemykin、Viktor V. Zhdankin

  DOI：10.1039/c9cc04203b

  日期：——

  A ditriflate derivative of 2-iodoxybenzoic acid (IBX) was prepared by the reaction of IBX with trifluoromethanesulfonic acid and characterized by single crystal X-ray crystallography. IBX-ditriflate is the most powerful oxidant in a series of structurally similar IBX derivatives which is best illustrated by its ability to readily oxidize hydrocarbons and the oxidation resistant polyfluoroalcohols.

  通过IBX与三氟甲磺酸的反应制备2-碘氧基苯甲酸（IBX）的二三氟甲磺酸酯衍生物，并通过单晶X射线晶体学表征。IBX-二甲苯磺酸盐是一系列结构相似的IBX衍生物中最强大的氧化剂，其易于氧化碳氢化合物和抗氧化多氟醇的能力得到了最好的说明。
• SnX2/Al-promoted formylation of per(poly)fluoroalkyl halides with N,N-dimethylformamide
  作者：Chang-Ming Hu、Jian Chen

  DOI：10.1016/0022-1139(93)02946-c

  日期：1994.5

  In the presence of catalytic amounts of stannous salts (20 mol%) and aluminium powder, per(poly)fluoroalkyl iodides or bromides react smoothly with DMF under mild conditions to give the corresponding per(poly)fluoroalkyl aldehydes in good to excellent yield. A tin-containing intermediate was obtained. A possible mechanism is proposed.

  在催化量的亚锡盐（20摩尔％）和铝粉的存在下，全（聚）氟代烷基碘或溴化物在温和的条件下与DMF平稳反应，以良好至极好的收率得到相应的全（聚）氟代烷基醛。得到含锡的中间体。提出了一种可能的机制。