6-oxaspiro[4.5]decane-8,10-dione | 372120-70-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-oxaspiro[4.5]decane-8,10-dione
• CAS: 372120-70-2
• 化学式: C₉H₁₂O₃
• 分子量: 168.192
• InChiKey: XTCQROICRQIXNU-UHFFFAOYSA-N

物化性质

• 沸点：
  339.4±32.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-oxaspiro[4.5]decane-8,10-dione 、 溴甲烷 在 碘 、 magnesium 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以88.2%的产率得到
  参考文献：
  名称：

  由氧杂螺[4.5]癸烷二酮合成的可降解型光刻胶树脂单体及其合成方法

  摘要：

  本发明公开了由氧杂螺[4.5]癸烷二酮合成的可降解型光刻胶树脂单体及其合成方法，涉及光刻胶树脂领域，该树脂单体的结构式为：其中R1为饱和烷烃或者环烷烃，R2为氢或者甲基。其合成方法为：6‑氧杂螺[4.5]癸烷‑8,10‑二酮(Ⅰ)与烷基格氏试剂或者环烷基格氏试剂反应得到中间体(Ⅱ)；在碱性条件下，中间体(Ⅱ)与丙烯酰氯或者甲基丙烯酰氯反应得到树脂单体(Ⅲ)。本发明提供的树脂单体与其它树脂单体聚合形成的聚合树脂具有更好的耐刻蚀性能，有利于改善显影后图形的边缘粗糙度，大大提高了光刻图案的分辨率，并且，增加了聚合树脂在脂溶性溶剂中的溶解度。

  公开号：

  CN111777587A
• 作为产物：
  描述：

  1-乙炔基环戊醇 在 mercury(II) diacetate 硫酸 、 potassium tert-butylate 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 叔丁醇 为溶剂， 反应 18.25h， 生成 6-oxaspiro[4.5]decane-8,10-dione
  参考文献：
  名称：

  Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener

  摘要：

  Structure-activity relationships were investigated on the tricyclic dihydropyridine ( DHP) K-ATP openers 9-(3-bromo-4-fluorophenyl)-5,9- dihydro-3H, 4H-2,6-dioxa-4-azacyclopenta[ b] naphthalene-1,8-dione ( 6) and 10( 3-bromo-4-fluorophenyl)-9,10-dihydro-1H, 8H-2,7-dioxa-9-azaanthracene-4,5-dione ( 65). Substitution off the core of the DHP, absolute stereochemistry, and aromatic substitution were evaluated for KATP channel activity using Ltk-cells stably transfected with the Kir6.2/SUR2B exon 17- splice variant and in an electrically stimulated pig bladder strip assay. A select group of compounds was evaluated for in vitro inhibition of spontaneous bladder contractions. Several compounds were found to have the unique characteristic of partial efficacy in both the cell-based and electrically stimulated bladder strip assays but full efficacy in inhibiting spontaneous bladder strip contractions. For compound 23b, this profile was mirrored in vivo where it was fully efficacious in inhibiting spontaneous myogenic bladder contractions but only partially able to reduce neurogenically mediated reflex bladder contractions.

  DOI：

  10.1021/jm060549u

文献信息

• Pyrano piperidino and thiopyrano compounds and methods of use
  申请人：——

  公开号：US20030055035A1

  公开（公告）日：2003-03-20

  1 The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.

  本发明提供了一种新型的化合物I，可用于超极化细胞膜、打开钾通道、放松平滑肌细胞和抑制膀胱收缩。
• US6642222B2
  申请人：——

  公开号：US6642222B2

  公开（公告）日：2003-11-04
• 由氧杂螺[4.5]癸烷二酮合成的可降解型光刻胶树脂单体及其合成方法
  申请人：徐州博康信息化学品有限公司

  公开号：CN111777587A

  公开（公告）日：2020-10-16

  本发明公开了由氧杂螺[4.5]癸烷二酮合成的可降解型光刻胶树脂单体及其合成方法，涉及光刻胶树脂领域，该树脂单体的结构式为：其中R1为饱和烷烃或者环烷烃，R2为氢或者甲基。其合成方法为：6‑氧杂螺[4.5]癸烷‑8,10‑二酮(Ⅰ)与烷基格氏试剂或者环烷基格氏试剂反应得到中间体(Ⅱ)；在碱性条件下，中间体(Ⅱ)与丙烯酰氯或者甲基丙烯酰氯反应得到树脂单体(Ⅲ)。本发明提供的树脂单体与其它树脂单体聚合形成的聚合树脂具有更好的耐刻蚀性能，有利于改善显影后图形的边缘粗糙度，大大提高了光刻图案的分辨率，并且，增加了聚合树脂在脂溶性溶剂中的溶解度。
• Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3<i>H</i>,4<i>H</i>-2,6-dioxa-4- azacyclopenta[<i>b</i>]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener
  作者：Robert J. Altenbach、Michael E. Brune、Steven A. Buckner、Michael J. Coghlan、Anthony V. Daza、Adebola Fabiyi、Murali Gopalakrishnan、Rodger F. Henry、Albert Khilevich、Michael E. Kort、Ivan Milicic、Victoria E. Scott、Jamie C. Smith、Kristi L. Whiteaker、William A. Carroll

  DOI：10.1021/jm060549u

  日期：2006.11.1

  Structure-activity relationships were investigated on the tricyclic dihydropyridine ( DHP) K-ATP openers 9-(3-bromo-4-fluorophenyl)-5,9- dihydro-3H, 4H-2,6-dioxa-4-azacyclopenta[ b] naphthalene-1,8-dione ( 6) and 10( 3-bromo-4-fluorophenyl)-9,10-dihydro-1H, 8H-2,7-dioxa-9-azaanthracene-4,5-dione ( 65). Substitution off the core of the DHP, absolute stereochemistry, and aromatic substitution were evaluated for KATP channel activity using Ltk-cells stably transfected with the Kir6.2/SUR2B exon 17- splice variant and in an electrically stimulated pig bladder strip assay. A select group of compounds was evaluated for in vitro inhibition of spontaneous bladder contractions. Several compounds were found to have the unique characteristic of partial efficacy in both the cell-based and electrically stimulated bladder strip assays but full efficacy in inhibiting spontaneous bladder strip contractions. For compound 23b, this profile was mirrored in vivo where it was fully efficacious in inhibiting spontaneous myogenic bladder contractions but only partially able to reduce neurogenically mediated reflex bladder contractions.