1-methyl-1H-quinoline-4-thione | 6291-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-methyl-1H-quinoline-4-thione
• 英文别名: 1-Methyl-1H-chinolin-4-thion；1-methyl-quinolin-4-thione；1-methylquinoline-4(1H)-thione；1-methylquinoline-4-thione
• CAS: 6291-51-6
• 化学式: C₁₀H₉NS
• 分子量: 175.254
• InChiKey: UHFHXGARFLWEAF-UHFFFAOYSA-N

物化性质

• 沸点：
  259.7±50.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)
• 溶解度：
  25.2 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-1H-quinoline-4-thione 生成 sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxylatopropan-2-yloxyimino)acetyl]amino]-3-[(1-methylquinolin-1-ium-4-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  参考文献：
  名称：

  NAKAGAVA, SUSUMU;FUKATSU, XIROSI;MITOMO, RYUDZI;KATO, JOSIAKI

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯喹啉 在 sodium hydrogensulfide 、 乙醇 作用下， 生成 1-methyl-1H-quinoline-4-thione
  参考文献：
  名称：

  THIOCARBONYLS. V. N-METHYL-4-THIOQUINOLONE DERIVATIVES

  摘要：

  DOI：

  10.1021/jo01149a025

文献信息

• 1-dethia-2-thia-cephalosporanic acids
  申请人：Uclaf; Roussel

  公开号：US04908359A1

  公开（公告）日：1990-03-13

  1-dethia-2-thia-cephalosporanic acids of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## R.sub.b --NH--and ##STR3## R.sub.a is an organic radical R.sub.i and R.sub.j are individually selected from the group consisting of hydrogen, aliphatic, aromatic and heterocycle or taken together with the nitrogen atom form an optionally substituted heterocycle, R.sub.b is optionally substituted carbocyclic or heterocyclic aryl, R.sub.1B is --[CH.dbd.CH].sub.n1 --CH.sub.2 --S--R.sub.m, n.sub.1 is 0, 1 or 2, Rm is an unsaturated radical including a positively charged and doubly bonded nitrogen atom and bonded to the sulfur atom through a carbon atom, R.sub.4 is hydrogen or methoxy, n.sub.2 is 0, 1 or 2 and A is selected from the group consisting of hydrogen, alkali metal ion, or alkaline earth metal ion, magnesium ion, ammonium ion, an organic amine base and an ester group or --COOA is --COO.sup.- and their non-toxic, pharmaceutically acceptable acid addition salts, having antibiotic activity.

  1-脱氧-2-噻吩-头孢霉酸，其化学公式为##STR1##，其中R选自##STR2## R.sub.b --NH--和##STR3##的组。R.sub.a是一个有机基团，R.sub.i和R.sub.j分别选自氢、脂肪族、芳香族和杂环，或者与氮原子一起形成一个可选取代的杂环。R.sub.b是一个可选取代的碳环或杂环芳基。R.sub.1B是--[CH.dbd.CH].sub.n1 --CH.sub.2 --S--R.sub.m，n.sub.1是0、1或2。Rm是一个不饱和基团，包括一个带正电荷的双键氮原子，并通过一个碳原子与硫原子连接。R.sub.4是氢或甲氧基，n.sub.2是0、1或2。A选自氢、碱金属离子、碱土金属离子、镁离子、铵离子、有机胺碱和酯基或--COOA的组，--COOA是--COO.sup.-，以及它们的非毒性、药理可接受的酸加成盐，具有抗生素活性。
• POLYMERIZABLE COMPOUND AND OPTICAL ISOMER
  申请人：DIC Corporation

  公开号：US20180022716A1

  公开（公告）日：2018-01-25

  The present invention provides a polymerizable compound having high storage stability without causing crystal precipitation when added to a polymerizable composition. The present invention also provides a polymerizable composition containing the compound. When the filmy polymer produced through polymerization of the polymerizable composition is irradiated with UV light, it hardly discolors or peels from substrate. Further, the present invention provides a polymer produced through polymerization of the polymerizable composition and an optically anisotropic body using the polymer.

  本发明提供了一种聚合物化合物，具有高储存稳定性，添加到聚合物化合物时不会导致结晶沉淀。本发明还提供了含有该化合物的聚合物化合物。当通过聚合物化合物的聚合产生薄膜状聚合物时，若用紫外光照射，它几乎不会变色或脱落。此外，本发明提供了通过聚合物化合物的聚合产生的聚合物，以及使用该聚合物的光学各向异性体。
• REAKTIONEN VON THIOXOVRBINDUNGEN MIT N-CHLORAMIDEN VI.¹THIOCHINOLONE, DIHYDROIHIAZOLTHIONE UND DIHYDROISOTHIAZOLTHIONE MIT NATRIUM-N-CHLORBENZOLSULFONAMIDEN
  作者：Friedrich Boberg、Bernd Bruchmann、Angelika Herzberg、Albert Otten

  DOI：10.1080/10426509608029652

  日期：1996.1.1

  N-(dihydroheteroarylidene)arensulfonamides (D). Oxidation of some sulfimides (B) gives N-(arylsulfonyl)heteroareniumsulfonamidates (E). The situation of bonding is discussed for B–E. Reaktionen von Natrium-N-chlorbenzolsulfonamiden (1a–1e) mit N-Alkylthioxo-dihydroderivaten folgender Heterocyclen (A) sind untersucht worden: Chinolin, Isochinolin, Thiazol, Isothiazol, Benzothiazol, 1,2-Benzisothiazol, 2,1-Benzisothiazol

  摘要 研究了 N-氯苯磺酰胺钠 (1a-1e) 与以下杂环 (A) 的 N-烷基硫代二氢衍生物的反应：喹啉、异喹啉、噻唑、异噻唑、苯并噻唑、1,2-苯并异噻唑、2,1-苯并异噻唑, 1,2-苯并异噻唑 1,1-二氧化物。反应产物是 N-芳基磺酰基-S-(二氢杂亚芳基)亚磺酰亚胺(B)、N,N'-双(芳基磺酰基)杂芳基亚磺酰胺(C)和N-(二氢杂亚芳基)芳基磺酰胺(D)。一些磺酰亚胺 (B) 的氧化得到 N-(芳基磺酰基) 杂芳基磺酰胺 (E)。结合 B-E 的情况进行了讨论。Reaktionen von Natrium-N-chlorbenzolsulfonamiden (1a–1e) mit N-Alkylthioxo-dihydroderivaten fogender Heterocyclen (A) 和其他词： Chinolin, Isochinolin, Thiazol, Isothiazol
• [EN] POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY<br/>[FR] COMPOSÉ POLYMÉRISABLE ET CORPS OPTIQUEMENT ANISOTROPE
  申请人：DAINIPPON INK & CHEMICALS

  公开号：WO2017079867A1

  公开（公告）日：2017-05-18

  There is provided a polymerizable composition, by which discoloration or alignment defects are less likely to occur when a filmy polymer, which is obtained by adding a polymerizable compound to the polymerizable composition and polymerizing this composition, is irradiated with ultraviolet light. There are also provided a polymer obtained by polymerizing the polymerizable composition, and an optically anisotropic body using the polymer. The present invention provides a polymerizable low-wavelength dispersive or polymerizable reverse-wavelength dispersive compound having a partial structure represented by Formula (Z-0). Further, the present invention provides a composition containing the compound; a polymer obtained by polymerizing the composition; and an optically anisotropic body obtained by using the polymer.

  提供一种可聚合的组合物，通过该组合物得到的薄膜聚合物在紫外光照射时，不太容易发生变色或排列缺陷。还提供了通过聚合该聚合物组合物得到的聚合物，以及使用该聚合物的光学各向异性体。本发明提供了一种具有由式（Z-0）表示的部分结构的可聚合低波长色散或可聚合反波长色散化合物。此外，本发明提供了一种含有该化合物的组合物；通过聚合该组合物得到的聚合物；以及通过使用该聚合物得到的光学各向异性体。
• Carbon-Sulfur and Carbon-Selenium Double Bond Formation Through Thiolysis and Selenolysis of 4-Methylsulfanyl-Substituted Pyridinium and Quinolinium Halides
  作者：Jocelyne Levillain、Daniel Paquer、Aboubacary Sene、Michel Vazeux

  DOI：10.1055/s-1998-2002

  日期：1998.1

  4-Methylsulfanylpyridinium and -quinolinium salts 3 and 4 with alkyl groups such as methyl, allyl, benzyl, ethoxycarbonylmethyl, benzoylmethyl on the nitrogen atom were prepared by the Menschutkin-type reaction and some of them caused to react under either the thiolysis or selenolysis reaction conditions. N-Substituted pyridine-4-thiones 5 a - c and quinoline-4-thiones 6 a - e were formed at different rates in high isolated yield. On the other hand, two N-alkyl-4-selenopyridones 7 a,b together with three 4-selenoquinolones, 8 a,b,c were also produced in high chemical purity and characterized spectroscopically. In addition, 4, sulfanylpyridone 12 and 4-selenopyridone 13 with a N-tert-butyl group were obtained via Zincke's salt 9. The overall process provides a useful alternative to the otherwise difficult direct N-alkylation of thioxo- and selenoxopyridine systems.

  通过Menschutkin型反应制备了氮原子上带有甲基、烯丙基、苄基、乙氧羰基甲基、苯甲酰甲基等烷基的4-甲硫基吡啶鎓和喹啉鎓盐3和4，其中一些在硫解或硒解反应条件下发生反应。N-取代吡啶-4-硫酮5a-c和喹啉-4-硫酮6a-e以不同的速率形成，且分离收率很高。另一方面，两种N-烷基-4-硒代吡啶酮7a,b和三种4-硒代喹啉酮8a,b,c也以高化学纯度制备，并通过光谱学表征。此外，通过Zincke盐9获得了带有N-叔丁基的4-硫代吡啶酮12和4-硒代吡啶酮13。整个过程为硫代吡啶和硒代吡啶系统的直接N-烷基化提供了有用的替代方案。