1-(3-bromobenzyl)-2-oxo-N-(4-(trifluoromethoxy)phenyl)-1,2-dihydropyridine-3-carboxamide | 1571031-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-bromobenzyl)-2-oxo-N-(4-(trifluoromethoxy)phenyl)-1,2-dihydropyridine-3-carboxamide
• 英文别名: 1-[(3-bromophenyl)methyl]-2-oxo-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
• CAS: 1571031-26-9
• 化学式: C₂₀H₁₄BrF₃N₂O₃
• 分子量: 467.242
• InChiKey: NPJGPAGCTHPQIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE
  申请人：Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center

  公开号：US20140073634A1

  公开（公告）日：2014-03-13

  The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.
• [EN] HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE<br/>[FR] MODULATEURS HÉTÉROCYCLIQUES DE L'ACTIVITÉ DU FACTEUR HIF UTILISÉS POUR LE TRAITEMENT DE MALADIES
  申请人：JONES PHILIP

  公开号：WO2014031928A2

  公开（公告）日：2014-02-27

  The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.