6-methoxy-hexan-3-one | 57134-32-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-methoxy-hexan-3-one
• 英文别名: 6-Methoxy-hexan-3-on；6-Methoxyhexan-3-one
• CAS: 57134-32-4
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: RHLGBJOTMLFCPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-methoxy-hexan-3-one 、 异丙胺 在 乙醇 、 镍 作用下， 150.0 ℃ 、13.73 MPa 条件下， 生成 (1-ethyl-4-methoxy-butyl)-isopropyl-amine
  参考文献：
  名称：

  Synthesis of the Branched Chain 5-Isopropylaminoamyl and 4-Isopropylaminobutyl Ethers and of the Bromides Derived from Them^1,2

  摘要：

  DOI：

  10.1021/ja01159a071
• 作为产物：
  描述：

  6-Methoxy-2-hexin 生成 6-methoxy-hexan-3-one
  参考文献：
  名称：

  异构甲氧基-2-己炔的硼氢化反应中的指导作用

  摘要：

  将一系列异构的甲氧基-2-炔烃硼氢化，以确定甲氧基对硼氢化方向的影响。甲氧基的作用是将硼原子引导到最靠近它的三键侧。当甲氧基接近不饱和位点时，指导作用的强度增加。但是，当取代基与三键相邻时，空间相互作用变得显着。

  DOI：

  10.1016/s0022-328x(00)94141-x

文献信息

• MOLECULAR PRECURSOR COMPOUNDS FOR ZINC-GROUP 13 MIXED OXIDE MATERIALS
  申请人：Precursor Energetics, Inc.

  公开号：US20150218190A1

  公开（公告）日：2015-08-06

  Molecular precursor compounds, processes and compositions for making Zn-Group 13 mixed oxide materials including IZO, GZO, AZO and BZO, by providing inks comprising a molecular precursor compound having the formula M A a Zn(OROR) 3a+2 , and printing or depositing the inks on a substrate. The printed or deposited ink films can be treated to convert the molecular precursor compounds to a material.

  分子前体化合物、制备Zn-Group 13混合氧化物材料（包括IZO、GZO、AZO和BZO）的过程和组合物，方法是提供包含具有公式M的分子前体化合物的油墨，在基底上印刷或沉积这些油墨。印刷或沉积的油墨膜可以经处理转化为材料。
• Substituted Bicyclic Dihydropyrimidinones And Their Use As Inhibitors Of Neutrophil Elastase Activity
  申请人：GNAMM Christian

  公开号：US20140249129A1

  公开（公告）日：2014-09-04

  This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

  这项发明涉及公式1的取代双环二氢嘧啶酮及其作为中性粒细胞弹性蛋白酶活性抑制剂的用途，包含这些化合物的药物组合物，以及将其用作治疗和/或预防肺部、胃肠道和泌尿系统疾病、皮肤和眼睛的炎症性疾病以及其他自身免疫和过敏性疾病、移植物排斥反应和肿瘤性疾病的方法。
• SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
  申请人：GNAMM Christian

  公开号：US20140221335A1

  公开（公告）日：2014-08-07

  This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

  该发明涉及式1的取代双环二氢嘧啶酮及其用作中性粒细胞弹性蛋白酶活性抑制剂的药物组合物，以及使用它们作为治疗和/或预防肺部、胃肠道和泌尿系统疾病、皮肤和眼部炎症性疾病、以及其他自身免疫和过敏性疾病、移植物排斥反应和肿瘤性疾病的药剂的方法。
• ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF
  申请人：Suda Yoshimitsu

  公开号：US20110034439A1

  公开（公告）日：2011-02-10

  To provide an antitumor agent which exhibits excellent c-Met inhibitory effect and mitigates side effects by virtue of selectively affecting to tumor cells in which c-Met is specifically expressed. The invention provides an acylthiourea compound represented by formula (I): (wherein each of R 1 and R 2 , which may be the same or different, represents a hydrogen atom, an optionally substituted C 1-6 alkyl group, an optionally substituted C 3-10 cycloalkyl group, an optionally substituted C 6-14 aromatic hydrocarbon group, or an optionally substituted saturated or unsaturated heterocyclic group, or R 1 and R 2 may form, together with the nitrogen atom to which they are attached, an optionally substituted nitrogen-containing heterocyclic ring; R 3 represents a C 1-6 alkyl group; and each of R 4 , R 5 , and R 6 , which may be identical to or different from one another, represents a hydrogen atom, a halogen atom, an optionally substituted C 1-6 alkyl group, a C 1-6 alkoxy group, a C 1-6 alkylamino group, an optionally substituted aromatic hydrocarbon group, or an optionally substituted saturated or unsaturated heterocyclic group, or R 5 and R 6 may form a ring together with the phenyl ring to which they are attached) or a salt thereof.

  提供一种抗肿瘤剂，其表现出优异的c-Met抑制作用，并通过选择性地影响c-Met特异表达的肿瘤细胞来减轻副作用。本发明提供一种由式(I)表示的酰基硫脲化合物：（其中，R1和R2中的每一个，可以相同也可以不同，表示氢原子，可选取代的C1-6烷基，可选取代的C3-10环烷基，可选取代的C6-14芳香烃基，或可选取代的饱和或不饱和杂环基，或R1和R2可以与它们所附着的氮原子一起形成一个可选取代的含氮杂环环；R3表示C1-6烷基；R4、R5和R6中的每一个，可以相同也可以不同，表示氢原子，卤素原子，可选取代的C1-6烷基，C1-6烷氧基，C1-6烷基氨基，可选取代的芳香烃基，或可选取代的饱和或不饱和杂环基，或R5和R6可以与它们所附着的苯环一起形成一个环）。或其盐。
• MOLECULAR PRECURSOR COMPOUNDS FOR INDIUM GALLIUM ZINC OXIDE MATERIALS
  申请人：TRANSTRON SOLUTIONS LLC

  公开号：EP3102541A1

  公开（公告）日：2016-12-14