8-chlorodibenz<1,4>oxazepine-10(11H)-carboxylic acid hydrazide | 19395-84-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-chlorodibenz<1,4>oxazepine-10(11H)-carboxylic acid hydrazide
• 英文别名: 8-Chlor-10,11-dihydro-dibenz<1,4>oxazepin-10-carbonsaeurehydrazid；8-chloro-11H-dibenzo[b,f][1,4]oxazepine-10-carboxylic acid hydrazide；8-chloro-10,11-dihydrodibenz-[b,f][1,4]oxazepine-10-carboxylic acid hydrazide；8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide；3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide
• CAS: 19395-84-7
• 化学式: C₁₄H₁₂ClN₃O₂
• 分子量: 289.721
• InChiKey: KWJIZZUDGRGHJS-UHFFFAOYSA-N

物化性质

• 密度：
  1.412±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-chlorodibenz<1,4>oxazepine-10(11H)-carboxylic acid hydrazide 生成 3-chloro-N'-(4-methylsulfanylbutanoyl)-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide
  参考文献：
  名称：

  MUELLER, R. A.

  摘要：

  DOI：

文献信息

• Dibenzoxazepine N-carboxylic acid hydrazides and derivatives
  申请人：G. D. Searle & Co.

  公开号：US03989719A1

  公开（公告）日：1976-11-02

  Derivatives of the dibenzoxazepine N-carboxylic acid hydrazides are acylated to yield N,N'-diacyl hydrazines which are useful pharmacological agents as is evidenced by their acetylcholine antagonist, prostaglandin antagonist, and 5-hydroxytryptamine antagonist activity.

  二苯并噁唑啉-N-羧酸腙的衍生物经酰化反应形成N,N'-二酰基腙，这些化合物具有抗乙酰胆碱、前列腺素和5-羟色胺拮抗活性，被证明是有用的药理剂。
• 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,
  申请人：G.D. Searle & Co.

  公开号：US04559337A1

  公开（公告）日：1985-12-17

  This invention relates to 8-chlorodibenz[b,f][1,4]-oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides that are useful as prostaglandin antagonists and analgesic agents.

  本发明涉及8-氯二苯并[b,f][1,4]-噁唑烷-10(11H)-羧酸，2-(含烷氧基酰基)腙类化合物，其可用作前列腺素拮抗剂和镇痛药物。
• Substituted dibenzoxazepine compounds for the treatment of convulsions,
  申请人：G. D. Searle & Co.

  公开号：US05393747A1

  公开（公告）日：1995-02-28

  The present invention provides methods for treating convulsions, ischemia and other diseases responsive to prostaglandin-E.sub.2 antagonists in an animal comprising administering a therapeutically-effective amount of a substituted dibenzoxazepine compound of Formula I, or a pharmaceutically-acceptable salt thereof, to the animal: ##STR1## wherein Y is oxygen, sulfur, --SO-- or --SO.sub.2 --, R.sup.1 is hydrogen, halogen or --CF.sub.3, R.sup.2 is hydrogen, halogen, --OH or --OCH.sub.3, R.sup.3 is hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl, m is an integer of from 1 to 5, X is ##STR2## R.sup.4 is hydrogen, alkyl, aryl, alkyl-substituted aryl, trifluoromethyl-substituted aryl or aryl-substituted alkyl, and R.sup.5 and R.sup.6 are each independently hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl.

  本发明提供了治疗惊厥、缺血和其他对前列腺素E.sub.2拮抗剂敏感的疾病的方法，包括向动物中投与式I的取代二苯并噻吩化合物或其药学上可接受的盐的治疗有效量： ##STR1## 其中，Y是氧、硫、--SO--或--SO.sub.2--，R.sup.1是氢、卤素或--CF.sub.3，R.sup.2是氢、卤素、--OH或--OCH.sub.3，R.sup.3是氢、烷基、芳基、烷基取代的芳基或芳基取代的烷基，m是1至5的整数，X是 ##STR2## R.sup.4是氢、烷基、芳基、烷基取代的芳基、三氟甲基取代的芳基或芳基取代的烷基，R.sup.5和R.sup.6各自独立地是氢、烷基、芳基、烷基取代的芳基或芳基取代的烷基。
• Substituted dibenzoxazepine compounds
  申请人：G. D. Searle & Co.

  公开号：US05378840A1

  公开（公告）日：1995-01-03

  The present invention provides dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了公式I的二苯并噁唑化合物：##STR1## 作为用于治疗疼痛的镇痛剂，其中包括与药学上可接受的载体组合的公式I化合物的治疗有效量的药物组合物，以及通过向动物投与公式I化合物的治疗有效量来消除或缓解动物疼痛的方法。
• 1-(Substituted amino)alkanoyl-2-(dibenzoxapine-10-carbonyl)hydrazines
  申请人：G. D. Searle & Co.

  公开号：US04170593A1

  公开（公告）日：1979-10-09

  The reaction of 1-(halo/cyano/sulfonyloxy)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazin es with an amine affords the corresponding 1-(substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines which compounds are useful anti-inflammatory or anti-diarrheal agents.

  1-(卤/氰/磺氧基)烷酰基-2-(二苯并噁唑-10-羰基)腙与胺反应，得到相应的1-(取代氨基)烷酰基-2-(二苯并噁唑-10-羰基)腙，这些化合物可用作有用的抗炎或抗腹泻剂。