2,2-bishydroxymethyl adamantane | 33101-10-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-bishydroxymethyl adamantane
• 英文别名: (adamantane-2,2-diyl)dimethanol；2,2-Di-(hydroxymethyl)-adamantan；2,2-adamantane dimethanol；[2-(hydroxymethyl)-2-adamantyl]methanol
• CAS: 33101-10-9
• 化学式: C₁₂H₂₀O₂
• 分子量: 196.29
• InChiKey: DLAXNKZSEACRIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-bishydroxymethyl adamantane 在 对甲苯磺酸 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 水 、 1,2-二氯乙烷 为溶剂， 反应 2.75h， 生成
  参考文献：
  名称：

  Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents

  摘要：

  In the present study, endoperoxide and 4-anilinognazoline were conjugated to obtain a series of compounds. These conjugates exhibited high antiproliferative potency against a number of cancer cell lines, including the epidermal growth factor receptor (EGFR) L858R/T790M mutant cell. Compound 5 was selected as a representative for mechanistic study. Further experiments revealed the conjugate's reactive oxygen species (ROS) generating ability, apoptosis inducing activity and involvement in EGFR downstream signaling pathways. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2017.02.023
• 作为产物：
  描述：

  dimethyl adamantane-2,2-dicarboxylate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 8.0h， 以93%的产率得到2,2-bishydroxymethyl adamantane
  参考文献：
  名称：

  Design and synthesis of bioactive adamantane spiro heterocycles

  摘要：

  Spiro[aziridine-2,2'-adamantanes] I and 2, spiro[azetidine-2,2'-adamantanes] 3 and 5, spiro[azetidine-3,2'-adamantane] 13, spiro[piperidine-4,2'-adamantanes] 25 and 27, and spiro barbituric analog 18 were synthesized and tested for their anti-influenza A virus properties and for trypanocidal activity. The effect of ring size on potency was investigated. Piperidine 25 showed significant anti-influenza A virus activity, being 12-fold more active than amantadine, about 2-fold more active than rimantadine, and 54-fold more potent than ribavirin. It also proved to be the most active of the compounds tested against bloodstream forms of the African trypanosome, Trypanosoma brucei, being 1.5 times more potent than rimantadine and at least 25 times more active than amantadine. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.108

文献信息

• 2-乙烯基氧甲基-2-羟甲基金刚烷和2,2-双(乙 烯基氧甲基)金刚烷及它们的制造方法
  申请人：日本电石工业株式会社

  公开号：CN104220407B

  公开（公告）日：2016-09-28

  本发明提供新的化合物及其制造方法，所述化合物为低臭味、低挥发性，作为固化性优异的聚合组合物原料是有用的。式(I)所示的2,2‑双(乙烯基氧甲基)金刚烷和式(II)所示的2‑乙烯基氧甲基‑2‑羟甲基金刚烷以及它们的制造方法。
• HYDROXYL-CONTAINING MONOMER, POLYMER, RESIST COMPOSITION, AND PATTERNING PROCESS
  申请人：Kinsho Takeshi

  公开号：US20090239179A1

  公开（公告）日：2009-09-24

  A hydroxyl-containing monomer of formula (1) is provided wherein R 1 is H, F, methyl or trifluoromethyl, R 2 and R 3 are monovalent C 1 -C 15 hydrocarbon groups, or R 2 and R 3 may form an aliphatic ring. The monomers are useful for the synthesis of polymers which have high transparency to radiation of up to 500 nm and the effect of controlling acid diffusion so that the polymers may be used as a base resin to formulate radiation-sensitive resist compositions having a high resolution.

  提供了一种含有羟基单体的化学式（1），其中R1为H、F、甲基或三氟甲基，R2和R3为一价的C1-C15烃基，或R2和R3可以形成脂肪环。这些单体可用于合成具有高透射性的聚合物，透射波长可达500纳米，并具有控制酸扩散的效果，因此这些聚合物可用作基础树脂，制备具有高分辨率的辐射敏感型光阻组合物。
• POLYCARBONATE RESIN COMPOSITION, AND MOLDED ARTICLE, FILM, PLATE AND INJECTION-MOLDED ARTICLE EACH COMPRISING SAME
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2594608A1

  公开（公告）日：2013-05-22

  The invention is to provide a polycarbonate resin composition and a molded polycarbonate resin article which combine excellent transparency and strength and which are suitable for use in the field of building materials, electrical/electronic field, automotive field, field of optical parts, etc. The invention relates to a polycarbonate resin composition containing a polycarbonate resin and an impact strength modifier, the polycarbonate resin containing structural units which are derived from a dihydroxy compound that has the portion represented by the following general formula (1) as part of the structure thereof and having a glass transition temperature lower than 145°C and a molded polycarbonates resin article obtained by molding the composition. The polycarbonate resin composition gives a molded object having a thickness of 3 mm which has a total light transmittance of 60% or higher.

  本发明旨在提供一种聚碳酸酯树脂组合物和一种模塑聚碳酸酯树脂制品，它们兼具优异的透明度和强度，适用于建筑材料领域、电气/电子领域、汽车领域、光学部件领域等。本发明涉及一种含有聚碳酸酯树脂和抗冲击强度改性剂的聚碳酸酯树脂组合物，该聚碳酸酯树脂含有由二羟基化合物衍生的结构单元，该二羟基化合物的部分结构由以下通式（1）表示，其玻璃化转变温度低于 145°C，本发明还涉及通过模塑该组合物获得的模塑聚碳酸酯树脂制品。该聚碳酸酯树脂组合物可制成厚度为 3 毫米的模塑物，其总透光率为 60% 或更高。
• POLYCARBONATE RESIN COMPOSITION AND MOLDED ARTICLE THEREOF
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2692798A1

  公开（公告）日：2014-02-05

  The present invention provides a polycarbonate resin composition with an excellent balance of weather resistance, impact resistance, light-blocking effect and the like, and a molded article thereof. The present invention relates to a polycarbonate resin composition, comprising: a polycarbonate resin containing a structural unit derived from a dihydroxy compound having a moiety represented by the following formula (1) [provided that a case where the moiety represented by formula (1) is a moiety constituting -CH2-O-H is excluded]; and an elastomer composed of a core•shell structure, wherein a core layer of the elastomer is at least one member selected from the group consisting of an alkyl (meth)acrylate and a (meth)acrylic acid, and a polycarbonate resin molded article obtained by molding the polycarbonate resin composition.

  本发明提供了一种在耐候性、抗冲击性、遮光效果等方面具有良好平衡的聚碳酸酯树脂组合物及其模塑制品。本发明涉及一种聚碳酸酯树脂组合物，包括聚碳酸酯树脂，其结构单元来源于具有下式（1）所代表分子的二羟基化合物[但不包括式（1）所代表的分子是由-CH2-O-H 构成的分子的情况]；以及由芯壳结构组成的弹性体，其中弹性体的芯层是至少一种选自烷基（甲基）丙烯酸酯和（甲基）丙烯酸组成的组的成员，以及通过模塑该聚碳酸酯树脂组合物而获得的聚碳酸酯树脂模塑制品。
• [EN] HDAC6 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE HDAC6 ET LEURS UTILISATIONS
  申请人：EIKONIZO THERAPAPEUTICS INC

  公开号：WO2021021979A3

  公开（公告）日：2021-04-08