4-[5-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid | 480390-90-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[5-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
• 英文别名: 4-[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]benzoic acid
• CAS: 480390-90-7
• 化学式: C₁₆H₉F₃N₂O₃
• 分子量: 334.254
• InChiKey: VAWVZZBAKTXYIT-UHFFFAOYSA-N

物化性质

• 沸点：
  474.4±55.0 °C(Predicted)
• 密度：
  1.420±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-甲基-2-丁烯 、 sodium chlorite 、 disodium hydrogenphosphate 、 4-(5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde 在 盐酸 作用下， 以 四氢呋喃 、 水 、 叔丁醇 为溶剂， 以89%的产率得到4-[5-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
  参考文献：
  名称：

  EP1405636

  摘要：

  公开号：

文献信息

• Function regulator for retinoid relative receptor
  申请人：——

  公开号：US20040157881A1

  公开（公告）日：2004-08-12

  The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulating agent comprising a compound represented by the formula: 1 wherein one of R 1 and R 2 is an optionally substituted monocyclic aromatic hydrocarbon group or an optionally substituted monocyclic aromatic heterocyclic group containing one heteroatom, and the other is a hydrogen atom and the like; B is a 5- or 6-membered heterocycle (except 1,3-azole); A is an optionally substituted aromatic hydrocarbon group or an optionally substituted aromatic heterocyclic group; and R 3 is a hydrogen atom and the like, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of diabetes mellitus, hyperlipidemia, impaired glucose tolerance or the like.

  本发明提供了一种调节视黄醛相关受体（除视黄酸受体外）功能的药剂，其包括以下式子所示的化合物：1其中R1和R2中的一个是可选的取代的单环芳烃基或含有一个杂原子的可选取代的单环芳杂环基，另一个是氢原子等；B是一个5-或6-成员杂环（除了1,3-唑）；A是一个可选取代的芳香烃基或可选取代的芳香杂环基；R3是氢原子等，或其盐，可用作预防或治疗糖尿病、高脂血症、糖耐量受损等的药剂。
• Compounds for Nonsense Suppression, and Methods for Their Use
  申请人：Almstead Neil G.

  公开号：US20090253699A1

  公开（公告）日：2009-10-08

  The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

  本发明涉及使用本发明的化合物或组合物治疗或预防与mRNA中无意义突变相关的疾病的方法、化合物和组合物。更具体地，本发明涉及用于抑制与mRNA中无意义突变相关的早期翻译终止的方法、化合物和组合物。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH
  申请人：Almstead Neil G.

  公开号：US20110046136A1

  公开（公告）日：2011-02-24

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由核酸序列编码的功能性蛋白质，其中包括一个无意义突变。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能性蛋白质的方法，以及利用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH
  申请人：PTC THERAPEUTICS, INC

  公开号：US20160199357A1

  公开（公告）日：2016-07-14

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由包含无意义突变的核酸序列编码的功能蛋白质。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能蛋白质的方法，并使用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• FUNCTION REGULATOR FOR RETINOID RELATIVE RECEPTOR
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1405636A1

  公开（公告）日：2004-04-07

  The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulatin agent comprising a compound represented by the formula: wherein one of R1 and R2 is an optionally substituted monocyclic aromatic hydrocarbon group or an optionally substituted monocyclic aromatic heterocyclic group containing one heteroatom, and the other is a hydrogen atom and the like; B is a 5- or 6-membered heterocycle (except 1,3-azole); A is an optionally substituted aromatic hydrocarbon group or an optionally substituted aromatic heterocyclic group; and R3 is a hydrogen atom and the like, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of diabetes mellitus, hyperlipidemia, impaired glucose tolerance or the like.

  本发明提供了一种视黄酸相关受体（视黄酸受体除外）功能调节剂，其包含由式表示的化合物： 其中 R1 和 R2 中的一个是任选取代的单环芳香烃基团或任选取代的含一个杂原子的单环芳香杂环基团，另一个是氢原子等；B 是 5 或 6 元杂环（1,3-唑除外）；A 是任选取代的芳香烃基团或任选取代的芳香杂环基团；以及 R3 是氢原子等，或其盐，可用作预防或治疗糖尿病、高脂血症、糖耐量受损或类似疾病的药物。