1-propene hexaethylene glycol monomethyl ether | 150669-65-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-propene hexaethylene glycol monomethyl ether
• 英文别名: 21-methanesulfonyloxy-4,7,10,13,16,19-hexa-oxa-undecosen；CH2=CHCH2O(EO)6CH3；Hexaethylene glycol allyl methyl ether；3-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ene
• CAS: 150669-65-1
• 化学式: C₁₆H₃₂O₇
• 分子量: 336.426
• InChiKey: SLNHAZDHMBCCCS-UHFFFAOYSA-N

物化性质

• 沸点：
  385.8±37.0 °C(Predicted)
• 密度：
  1.012±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  23
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-propene hexaethylene glycol monomethyl ether 、 在 bis(triphenylphosphine)benzylideneruthenium(II) dichloride 作用下， 以 二氯甲烷 为溶剂， 以30%的产率得到
  参考文献：
  名称：

  Synthesis of hydrophilic Fischer carbene complexes as organometallic marker and PEGylating agent for proteins

  摘要：

  Syntheses of Fischer carbene complexes with various hydrophilic tethers (4, 6a, 6b, 6c, 8a, 8b, 14a, 14b, 15 and 19) are described. The water-soluble carbene complex, 14b, was used to label and pegylate bovine serum albumin (BSA) without affecting its conformation. The red complex, 19, underwent a sharp color change to yellow on reaction with BSA, a feature that is potentially useful for developing assay methods. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2005.07.042
• 作为产物：
  描述：

  六甘醇 在 sodium hydride 、 silver(l) oxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 33.0h， 生成 1-propene hexaethylene glycol monomethyl ether
  参考文献：
  名称：

  Synthesis of hydrophilic Fischer carbene complexes as organometallic marker and PEGylating agent for proteins

  摘要：

  Syntheses of Fischer carbene complexes with various hydrophilic tethers (4, 6a, 6b, 6c, 8a, 8b, 14a, 14b, 15 and 19) are described. The water-soluble carbene complex, 14b, was used to label and pegylate bovine serum albumin (BSA) without affecting its conformation. The red complex, 19, underwent a sharp color change to yellow on reaction with BSA, a feature that is potentially useful for developing assay methods. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2005.07.042

文献信息

• [EN] MULTIVALENT INHIBITORS OF SERUM AMYLOID P COMPONENT<br/>[FR] INHIBITEURS POLYVALENTS DE LA COMPOSANTE P DES AMYLOIDES SERIQUES
  申请人：THERACARB INC

  公开号：WO2004099173A1

  公开（公告）日：2004-11-18

  Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are useful for treating amyloidosis and diseases associated with amyloidosis, for example Alzheimer's disease and maturity onset diabetes mellitus.

  新型甘油环状丙酮衍生物已经制备并证明能够抑制固定化D-脯氨酸衍生物与血清淀粉样蛋白P成分（SAP）的结合。因此，本发明的化合物可用于治疗淀粉样变性和与淀粉样变性相关的疾病，例如阿尔茨海默病和成人发病型糖尿病。
• Multivalent inhibitors of serum amyloid p component
  申请人：Bundle David

  公开号：US20070042936A1

  公开（公告）日：2007-02-22

  Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are useful for treating amyloidosis and diseases associated with amyloidosis, for example Alzheimer&supl;s disease and maturity onset diabetes mellitus.
• US5162402A
  申请人：——

  公开号：US5162402A

  公开（公告）日：1992-11-10
• US7553819B2
  申请人：——

  公开号：US7553819B2

  公开（公告）日：2009-06-30
• Synthesis of hydrophilic Fischer carbene complexes as organometallic marker and PEGylating agent for proteins
  作者：Debasis Samanta、Sudeshna Sawoo、Subrata Patra、Manju Ray、Michèle Salmain、Amitabha Sarkar

  DOI：10.1016/j.jorganchem.2005.07.042

  日期：2005.12

  Syntheses of Fischer carbene complexes with various hydrophilic tethers (4, 6a, 6b, 6c, 8a, 8b, 14a, 14b, 15 and 19) are described. The water-soluble carbene complex, 14b, was used to label and pegylate bovine serum albumin (BSA) without affecting its conformation. The red complex, 19, underwent a sharp color change to yellow on reaction with BSA, a feature that is potentially useful for developing assay methods. (c) 2005 Elsevier B.V. All rights reserved.