octadecyl bromoacetate | 18992-03-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: octadecyl bromoacetate
• 英文别名: n-octadecyl bromoacetate；Bromessigsaeure-octadecylester；Octadecylbromacetat；octadecyl 2-bromoacetate
• CAS: 18992-03-5
• 化学式: C₂₀H₃₉BrO₂
• 分子量: 391.432
• InChiKey: LOBRVJLEFHWKDI-UHFFFAOYSA-N

物化性质

• 熔点：
  89 °C
• 沸点：
  185 °C(Press: 5 Torr)
• 密度：
  1.042±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  23
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  octadecyl bromoacetate 在 盐酸 、 碳酸氢钠 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 反应 19.0h， 生成 octadecyl 2-[[(2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-yl]oxy]acetate
  参考文献：
  名称：

  3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats

  摘要：

  Structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has allowed the development of agents for treating reperfusion injury. These ascorbic acid derivatives inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rats. We found that 3-O-[(dodecylcarbonyl)methyl]ascorbic acid (8) was protective against reperfusion injury without directly influencing hemodynamics. 2-O-Octadecylascorbic acid (19) and 5,6-O-dodecylideneascorbic acid (15) also exhibited a marked effect on reperfusion injury, but significantly reduced the arterial blood pressure and heart rate in rats.

  DOI：

  10.1021/jm00087a017
• 作为产物：
  描述：

  硬脂醇 、 溴乙酸 在 对甲苯磺酸 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 生成 octadecyl bromoacetate
  参考文献：
  名称：

  某些阳离子尿嘧啶杀生物剂对广泛传播的细菌菌株的潜在抗菌活性的筛选

  摘要：

  合成并使用元素分析，FTIR，1 H-NMR和13分析了八种含有Schiff碱物种的新型基于尿嘧啶的阳离子表面活性剂核磁共振波谱 基于界面张力测量值和水/辛醇系统中的分配系数值，确定了合成的席夫碱及其阳离子衍生物的表面活性。合成的席夫碱及其阳离子衍生物被评估为针对不同细菌和真菌菌株的新型杀菌剂。结果表明，通过季铵化作用，合成的席夫碱的杀生物活性大大提高。阳离子表面活性剂作为杀菌剂的影响通过增加疏水链的长度和甲氧基的存在而增加。通过增加水/辛醇系统中的分配系数，还提高了杀菌活性。讨论了不同化合物的结构和表面活性/杀菌活性。

  DOI：

  10.1007/s11743-010-1229-0

文献信息

• <i>Retracted</i> : Synthesis, Characterization, and Surface Activities of Polymeric Cationic Thiol Surfactants in Aqueous Medium
  作者：Mohamed F. Zaky、Ibrahim A. Sabbah、Mostafa E. Hendawy、Reda S. Abdel Hameed、Nabel A. Negm

  DOI：10.1002/jsde.12233

  日期：2019.3

  including: surface tension (γ), effectiveness ( πcmc), concentration at micelle formation (CMC), efficiency (Pc20), maximum concentration at the interface (Γmax), and the average area occupied by each surfactant molecule at the interface at equilibrium ( A min) of surfactants solutions were established at 25°C. The surface tension and the critical micelle concentration values of the prepared surfactants were

  通过将溴乙酸烷基酯（即：溴乙酸辛酯，癸基，十二烷基，十四烷基，十六烷基和十八烷基）作为季铵化剂反应，合成了一系列阳离子聚氨酯表面活性剂[PQ 8-18 ]。胺类。通过甲苯二异氰酸酯（TDI）和三乙醇胺单体巯基乙酸酯的反应制备改性的聚氨酯。使用元素分析，傅立叶变换红外光谱（FTIR）和质子核磁共振来确认所制备表面活性剂的化学结构（11 H NMR）光谱。所制备聚合物的分子量测量表明，每种聚合物的链段平均含有10个单位的氨基甲酸乙酯-三乙醇胺巯基乙酸酯。所制备的表面活性剂包括以下表面活性：表面张力（γ），效率（π CMC），浓度在胶束形成（CMC），效率（PC 20），最大浓度在界面（Γ最大），和平均面积占用通过每个表面活性剂分子在平衡界面处（A min ）的表面活性剂溶液在25°C下建立。制备的表面活性剂的表面张力和临界胶束浓度值随着其烷基链长度的逐渐增加而逐渐降低。所制备的阳离子表面活性剂
• Polylactic acid composition
  申请人：Teijin Limited

  公开号：US08263690B2

  公开（公告）日：2012-09-11

  It is an object of the present invention to provide a composition which contains polylactic acid and has excellent heat stability, mechanical strength and color. The composition contains 0.001 to 0.1 part by weight of a metal catalyst and 0.001 to 0.5 part by weight of a phosphono-fatty acid ester based on 100 parts by weight of polylactic acid.

  本发明的目的是提供一种含有聚乳酸的组合物，具有优异的热稳定性、机械强度和颜色。该组合物包含重量百分比为0.001至0.1的金属催化剂和0.001至0.5的重量百分比的基于脂肪酸的磷酸酯，以100份聚乳酸为基础。
• Compositions stabilized with N-hydroxyiminodiacetic and dipropionic
  申请人：Ciba-Geigy Corporation

  公开号：US04720517A1

  公开（公告）日：1988-01-19

  N-hydroxyiminodiacetic and dipropionic acids and esters thereof corresponding to the formula ##STR1## are effective in stabilizing various organic materials against oxidative, thermal and actinic degradation, said derivatives being particularly effective as color improvers and process stabilizers in synthetic polymers containing phenolic antioxidants and/or metal salts of fatty acids and as stabilizers in lubricants.

  N-羟基亚胺二乙酸和二丙酸及其酯，其对应的化学式为##STR1##，对各种有机材料的氧化、热和光降解具有稳定作用。这些衍生物特别适用于含酚类抗氧化剂和/或脂肪酸金属盐的合成聚合物中作为色素改良剂和工艺稳定剂，并且也可用作润滑剂的稳定剂。
• POLYLACTIC ACID COMPOSITION
  申请人：Suzuki Hirotaka

  公开号：US20090062437A1

  公开（公告）日：2009-03-05

  It is an object of the present invention to provide a composition which contains polylactic acid and has excellent heat stability, mechanical strength and color. The composition contains 0.001 to 0.1 part by weight of a metal catalyst and 0.001 to 0.5 part by weight of a phosphono-fatty acid ester based on 100 parts by weight of polylactic acid.

  本发明的目的是提供一种含有聚乳酸的组合物，具有优异的热稳定性、机械强度和颜色。该组合物包含100份聚乳酸中的0.001至0.1份重量的金属催化剂和0.001至0.5份重量的基于磷脂酸酯的化合物。
• Method of treating a tumor or a viral disease by administering a 2' , 5' -oligoadenylate analog
  申请人：Koizumi Makoto

  公开号：US20100035976A1

  公开（公告）日：2010-02-11

  A method of treating a tumor or a viral disease by administering to a human the following 2′,5′-oligoadenylate analog: Wherein m is 0; n is 0 or 1; R 1 is alkoxy substituted by hydroxyl, mercapto, alkylthio substituted by hydroxyl or X 1 —X 2 —X 3 —S—; R 2 , R 3 , R 4 , R 5 and R 6 are hydroxyl, mercapto, alkylthio substituted by hydroxyl or X 1 —X 2 —X 3 —S—; R 7 is oxygen, sulfur, —NH—, or —O(CH 2 CH 2 O)q-, wherein q is 2 to 6, or oxyalkyleneoxy; R 8 is hydrogen or a 5′-phosphorylated oligonucleotide which has one hydroxyl removed from the 5′-phosphoric acid; E 1 is K 2 ; E 2 is K 1 ; E 3 is K 2 or K 3 and E 4 is K 1 , K 2 or K 3 ; K 1 is K 2 is K 3 is B is adeninyl; A is alkylene; D is alkyl or alkenyl; X 1 is alkyl or phenyl; X 2 is —C(═O)O—, —OC(═O)— or —C(═O)S—; and X 3 is alkylene.

  一种通过向人体内注射以下2′，5′-寡腺苷酸类似物来治疗肿瘤或病毒性疾病的方法：其中m为0；n为0或1；R1为烷氧基，被羟基，巯基，被羟基的烷基硫代基或X1—X2—X3—S—取代的烷氧基；R2，R3，R4，R5和R6为羟基，巯基，被羟基的烷基硫代基或X1—X2—X3—S—；R7为氧，硫，—NH—，或—O(CH2CH2O)q-，其中q为2至6，或氧烷氧基；R8为氢或一个5′-磷酸寡核苷酸，其5′-磷酸上有一个羟基被去除；E1为K2；E2为K1；E3为K2或K3，E4为K1，K2或K3；K1，K2和K3为B为腺苷基；A为烷基；D为烷基或烯基；X1为烷基或苯基；X2为—C(═O)O—，—OC(═O)—或—C(═O)S—；X3为烷基。