2-Deoxy-L-arabino-hexose | 23568-30-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Deoxy-L-arabino-hexose
• 英文别名: 2-deoxy-L-glucopyranose；2-deoxy-D-glucose；2-deoxy-L-glucose；(4S,5R,6S)-6-(hydroxymethyl)oxane-2,4,5-triol
• CAS: 23568-30-1
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: PMMURAAUARKVCB-HPASCFBVSA-N

物化性质

• 沸点：
  411.0±45.0 °C(Predicted)
• 密度：
  1.533±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Deoxy-L-arabino-hexose 在 吡啶 、 lithium aluminium tetrahydride 、 sodium azide 、 AG 1-X₄(OH^-) 、 AG 50-X₄(H⁺) 、 氯化铵 作用下， 以 四氢呋喃 、 甲醇 、 乙二醇甲醚 、 水 为溶剂， 反应 200.0h， 生成 methyl 3-azido-2,3,6-trideoxy-4-O-methanesulphonyl-α-L-arabino-hexopyranoside
  参考文献：
  名称：

  Synthesis of daunosamine

  摘要：

  DOI：

  10.1021/jo00174a028
• 作为产物：
  描述：

  tetra-O-acetyl-1-nitro-D-arabino-1,2-dideoxy-hexitol 在 barium dihydroxide 、 硫酸 作用下， 生成 2-Deoxy-L-arabino-hexose
  参考文献：
  名称：

  Synthesis of daunosamine

  摘要：

  DOI：

  10.1021/jo00174a028

文献信息

• Montmorillonite Clay Catalyzed Synthesis of Enantiomerically Pure 1,2,3,4-Tetrahydroquinolines
  作者：B. Reddy、J. Yadav、Syeda Meraj、P. Vishnumurthy、K. Narsimulu、A. Kunwar

  DOI：10.1055/s-2006-942528

  日期：2006.9

  Arylamines undergo smooth cyclization with 2-deoxy-d-ribose on the surface of montmorillonite KSF clay under mild conditions to afford the corresponding sugar-derived chiral tetrahydroquinolines in high yields with moderate diastereoselectivity. The assignment of the stereochemistry of the product was achieved by various NMR studies.

  在温和的条件下，芳胺与蒙脱石 KSF 粘土表面上的 2-脱氧-d-核糖顺利发生环化反应，以中等非对映选择性高产率得到相应的糖衍生手性四氢喹啉。通过各种核磁共振研究确定了产物的立体化学结构。
• Compositions for improving the health and appearance of skin
  申请人：Algenist Holdings, Inc.

  公开号：US10231907B2

  公开（公告）日：2019-03-19

  Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.

  本文提供了微藻护肤组合物以及改善皮肤健康和外观的方法。还提供了将多糖用于局部个人护理产品、化妆品和除皱组合物等应用的方法。本发明还提供了用于改善皮肤健康和外观的新型脱色微藻组合物。本发明还包括用于人体皮肤的不溶性多糖颗粒。
• [EN] QUINOXALINE-BASED D-A-D NEAR-INFRARED TWO-REGION FLUORESCENT MOLECULE, AND PREPARATION METHOD THEREFOR AND USE THEREOF<br/>[FR] MOLÉCULE FLUORESCENTE À DEUX RÉGIONS D-A-D PROCHE INFRAROUGE À BASE DE QUINOXALINE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION<br/>[ZH] 基于喹喔啉的D-A-D近红外二区荧光分子及其制备方法和应用
  申请人：[en]SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;[zh]中国科学院上海药物研究所

  公开号：WO2022156793A1

  公开（公告）日：2022-07-28

  一种基于喹喔啉的D-A-D近红外二区荧光分子及其制备方法和应用。所述基于喹喔啉的D-A-D近红外二区荧光分子选自通式I-1和I-2所示的化合物及它们的盐，可以用于制备显影剂，用于在生物组织及样品中进行体外定量检测和体内成像以及非生物组织的指示定量。
• Unusual stereoselectivity in sialic acid aldolase-catalyzed aldol condensations: synthesis of both enantiomers of high-carbon monosaccharides
  作者：Chun Hung Lin、Takeshi Sugai、Randall L. Halcomb、Yoshitaka Ichikawa、Chi Huey Wong

  DOI：10.1021/ja00052a008

  日期：1992.12

  An inversion of stereoselectivity in aldol condensations catalyzed by sialic acid aldolase (from Escherichia coli, Shinko American Inc.) was observed when L-mannose, 6-deoxy-L-mannose, L-talose, 2-deoxy-L-glucose, 2-deoxy-L-rhamnose, N-acetyl-L-mannosamine, D-gulose, D-arabinose, and 2-azido-2-deoxy-L-mannose were used as acceptor substrates. In all substrates tested, except the last three, a complete inversion of stereoselectivity was observed; i.e., the C-nucleophile of pyruvate attacks the re face of the acceptor carbonyl instead of the si face as in the normal case for the enantiomeric substrates. Examination of the product distribution during the course of enzymatic reactions indicates that the stereoselectivity is thermodynamically controlled in nature; i.e., attack on the re face would take place if the resulting product would be more stable than the one from the si face attack. Both enantiomers of several high-carbon monosaccharides are now accessible via the aldolase reactions. A new practical procedure has also been developed for the preparation of the aldolase products where unreacted pyruvate (usually used in 7-fold excess to drive the reaction) is decomposed with pyruvate decarboxylase to simplify product isolation.
• Compositions for Improving the Health and Appearance of Skin
  申请人：Avila Jeff

  公开号：US20090069213A1

  公开（公告）日：2009-03-12

  Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.