2-methyl-4-nonanolide | 33349-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2-methyl-4-nonanolide
• 英文别名: 3-methyl-5-pentyldihydrofuran-2(3H)-one；3-methyl-5-pentyl-dihydro-furan-2-one；3-Methyl-5-pentyl-dihydro-furan-2-on；2-methyl-γ-nonalactone；3-Methyl-5-pentyloxolan-2-one
• CAS: 33349-00-7
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: NNDGAEZRGPLTIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-4-nonanolide 、 一水合肼 生成 4-hydroxy-2-methyl-nonanoic acid hydrazide
  参考文献：
  名称：

  Blaise; Luttringer, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905, vol. 140, p. 792

  摘要：

  DOI：
• 作为产物：
  描述：

  2-Methylnonane-1,4-diol 生成 2-methyl-4-nonanolide
  参考文献：
  名称：

  KAVASAKI, AKIXIRO;TANIGUTI, MASANOBU;MARUYAMA, ISAO;MATSUI, MASAAKI

  摘要：

  DOI：

文献信息

• A Bond-Weakening Borinate Catalyst that Improves the Scope of the Photoredox α-C–H Alkylation of Alcohols
  作者：Kounosuke Oisaki、Motomu Kanai、Kentaro Sakai

  DOI：10.1055/s-0040-1707114

  日期：2020.8

  functionalization reactions is currently a major challenge in organic synthesis. In this paper, a novel bond-weakening catalyst that recognizes the hydroxy group of alcohols through formation of a borate is described. An electron-deficient borinic acid–ethanolamine complex enhances the chemical yield of the α-C–H alkylation of alcohols when used in conjunction with a photoredox catalyst and a hydrogen

  催化剂控制的，位点选择性的C（sp 3）–H官能化反应的发展目前是有机合成中的主要挑战。在本文中，描述了一种新型的键弱化催化剂，该催化剂通过形成硼酸盐来识别醇的羟基。与可见光照射下的光氧化还原催化剂和氢原子转移催化剂结合使用时，缺电子的硼酸-乙醇胺络合物可提高醇类α-CH烷基化的化学收率。该三元杂化催化剂体系可以例如应用于富含官能团的肽。
• Free Radical Addition of 2-Bromoalkanoic Acids to Alkenes
  作者：Taichi Nakano、Mikio Kayama、Yoichiro Nagai

  DOI：10.1246/bcsj.60.1049

  日期：1987.3

  The benzoyl peroxide-catalyzed reaction of 2-bromoalkanoic acids such as bromoacetic, 2-bromopropionic, and 2-bromobutyric acid with 1-alkenes was found to proceed through the addition of the C–Br bond across the double bond followed by cyclization affording 4-alkanolides in good yields.

  发现过氧化苯甲酰催化的 2-溴链烷酸（如溴乙酸、2-溴丙酸和 2-溴丁酸）与 1-烯烃的反应是通过在双键上添加 C-Br 键，然后环化得到 4 -链烷醇收率良好。
• PROCESS
  申请人：Wiebe Lars

  公开号：US20070249849A1

  公开（公告）日：2007-10-25

  The present invention relates to a process for preparing a lactone. The process comprises the steps of reacting an aldehyde with an organic halide in a carbon chain extension reaction to form an alcohol compound comprising a functional group capable of allowing for carbonylation of said alcohol compound, and then reacting said alcohol compound in a carbonylation reaction to form an hydroxycarboxylic acid; and cyclising the hydroxycarboxylic acid to produce the lactone.

  本发明涉及一种制备内酯的方法。该方法包括以下步骤：将醛与有机卤化物在碳链延伸反应中反应，形成含有功能基团的醇化合物，该功能基团能够允许醇化合物进行羰基化反应，然后在羰基化反应中反应所述醇化合物，以形成羟基羧酸；将羟基羧酸环化，以产生内酯。
• ANTIMICROBIAL POLYMYXINS FOR TREATMENT OF BACTERIAL INFECTIONS
  申请人：MICURX PHARMACEUTICALS, INC.

  公开号：US20160185823A1

  公开（公告）日：2016-06-30

  The present invention provides antimicrobial polymyxin compounds of the following formula I: or pharmaceutically acceptable salts, hydrates, or solvates thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

  本发明提供以下式I的抗微生物多粘菌素化合物或其药学上可接受的盐、水合物或溶剂化物，它们是抗菌剂，包含它们的制药组合物，使用它们的方法以及制备这些化合物的方法。
• HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1602354A1

  公开（公告）日：2005-12-07

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。